Table 2 Safety indexes will be detected for each volunteer in the study

Blood routine

Red blood cell, hemoglobin, white blood cell, white blood cell classification count, hematocrit, platelet, etc

When one volunteer will be recruited, these safe indexes will be detected for five times (0 month, 3rd month, 6th month, 9th month, 12th month) across whole study

Urine routine

PH, urine specific gravity, urobilinogen, urine blood, white blood cell, urine protein, glucose in urine, bilirubin, ketone body, urine red blood cell, etc

Liver function

Total protein, globulin, albumin, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, indirect bilirubin, urine bilirubin, urobilinogen, serum bile acid, gamma glutamyltranspeptidase, alkaline phosphatase, etc

Kidney function

Serum urea, uric acid, blood β-microglobulin, serum creatinine, etc

Blood sugar

Fasting blood sugar

Electrocardiogram

Chest leads, limb lead