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Table 1 Comparison of clinical features and laboratory results between HBV-ACLF patients with and without bacterial infections

From: The role of prophylactic antibiotics in hepatitis B virus-related acute-on-chronic liver failure patients at risk of bacterial infection: a retrospective study

  Patients without bacterial infection (n = 43) Patients with bacterial infection (n = 97) P-value
Clinical data    
 Age (years) 49 (37–56) 46 (38–56) 0.271
 Male sex, % (n) 100 (43) 86.6 (84) 0.010
 Underlying disease, % (n)    0.995
  Chronic hepatitis B 46.5 (20) 47.4 (46)
  Compensated cirrhosis 32.6 (14) 32.0 (31)
  Deompensated cirrhosis 20.9 (9) 20.6 (20)
 Complications, % (n)    
  Ascites 48.8 (21) 78.4 (76) 0.001
  GI hemorrhage 0 (0) 10.3 (10) 0.031
 Glucocorticoids, % (n) 30.2 (13) 29.9 (29) 0.968
 Prophylactic antibiotics, % (n) 67.4 (29) 21.2 (22) 0.000
Laboratory data    
 Alanine aminotransferase (U/L) 737 (251–1629) 529 (180–1238) 0.178
 Albumin (g/L) 32 (29–36) 32 (29–37) 0.087
 Total bilirubin (μmol/L) 190.3 (133.0–254.1) 270.27 (183.0–342.6) 0.003
 Creatinine (μmol/L) 65 (55–75) 70 (57–91) 0.136
 Sodium (mmol/L) 139.0 (134–140) 135 (131–138) 0.006
 White blood cell count (109/L) 5.4 (4.37–7.92) 7.08 (5.28–10.51) 0.036
 Neutrophil count (109/L) 3.58 (2.60–5.92) 5.76 (3.70–7.85) 0.008
 Hemoglobin (g/L) 133 (121–147) 121 (95–136) 0.001
 Platelet count (109/L) 98 (74–131) 91 (67–123) 0.308
 INR 1.85 (1.70–2.26) 2.25 (1.85–2.75) 0.001
 LMR 1.93 (1.27–2.74) 1.44 (1.01–2.07) 0.056
 NLR 3.03 (2.00–5.49) 5.19 (3.43–8.40) 0.003
 DIC score 4 (3–5) 5 (4–6) 0.001
Organ failure, % (n)    
 Liver 69.8 (30) 87.6 (85) 0.011
 Coagulation 18.6 (8) 44.3 (43) 0.004
 Kidney 14.0 (6) 15.5 (15) 0.817
 Cerebral 9.3 (4) 22.7 (22) 0.060
 Lung 4.7 (2) 9.3 (9) 0.348
 Circulation 4.7 (2) 19.6 (19) 0.022
Transplant-free survival probability (%)    
 28-day 86.0 54.5 0.000
 90-day 83.1 43.1 0.000
  1. Data are expressed as the median (interquartile range) or percent (number). Bold numbers represent significant difference (P < 0.05)
  2. ACLF acute-on-chronic liver failure, HBV Hepatitis B virus, HBV-ACLF Hepatitis B virus-related acute-on-chronic liver failure, GI gastrointestinal, INR international normalized ratio, LMR lymphocyte-to-monocyte ratio, NLR neutrophil-to-lymphocyte ratio, DIC disseminated intravascular coagulation
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