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Table 2 Predictors of bacterial infection in the univariate and multivariate analyses in patients with HBV-ACLF

From: The role of prophylactic antibiotics in hepatitis B virus-related acute-on-chronic liver failure patients at risk of bacterial infection: a retrospective study

Predictor Univariate analysis P-value Multivariate analysis P-value
OR (95% CI) OR (95% CI)
Age (years) 1.018 (0.989–1.048) 0.233
Gender 0.000 (0.000–0.000) 0.999
Underlying liver disease 1.035 (0.402–2.665) 0.932
Prior decompensation 1.136 (0.456–2.829) 0.784
Precipitating events 0.935 (0.159–5.495) 0.738
Total bilirubin (μmol/L) 1.004 (1.001–1.008) 0.015
Creatinine (μmol/L) 1.005 (0.996–1.013) 0.271
Sodium (mmol/L) 0.905 (0.837–0.979) 0.013
White blood cell count (109/L) 1.085 (0.982–1.199) 0.111
Neutrophil count (109/L) 0.996 (0.999–1.045) 0.870
Hemoglobin (g/L) 0.974 (0.958–0.990) 0.002
Platelet count (109/L) 0.995 (0.987–1.002) 0.166
INR 3.483 (1.590–7.628) 0.002
Ascites grade 1.951 (1.326–2.871) 0.001 1.802 (1.141–2.846) 0.012
Hepatic encephalopathy grade 2.528 (1.003–6.371) 0.049 2.840 (1.015–7.945) 0.047
LMR 0.732 (0.515–1.041) 0.083
NLR 0.988 (0.959–1.017) 0.402
DIC score 1.486 (1.168–1.890) 0.001
Glucocorticoids 0.984 (0.450–2.153) 0.968
Prophylactic antibiotics 0.142 (0.064–0.314) 0.000 0.135 (0.056–0.330) 0.000
  1. Bold-face font represents factors that are significant predictors of infection in multivariate analyses
  2. HBV-ACLF Hepatitis B virus-related acute-on-chronic liver failure, INR international normalized ratio, LMR lymphocyte-to-monocyte ratio, NLR neutrophil-to-lymphocyte ratio, DIC disseminated intravascular coagulation, OR odds ratio, CI confidence interval
  3. “–” represents factors that are not ultimately included in the multivariate analysis
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