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Table 2 Susceptibility of RGM to antimicrobial agents determined by the broth dilution method

From: Nontuberculous mycobacteria in China: incidence and antimicrobial resistance spectrum from a nationwide survey

Grouping/species

RGM (n = 128)

Antimicrobial agent

Broth dilution ranges (μg/ml)

MIC50

MIC90

Susceptible

Intermediate

Resistant

S (%)

I (%)

R (%)

Antimicrobial agents and susceptibility breakpoints (MICs) for testing rapidly growing mycobacteriaa

 Amikacin

1‒64

8

16

≤ 16

32

≥ 64

93.75

1.56

4.69

  Clarithromycin (3D)

0.06‒16

0.12

8

≤ 2

4

≥ 8

85.04

0

14.96

 Clarithromycin (14D)

8

> 16

44.09

2.36

53.5

 Imipenem

2‒64

> 64

> 64

≤ 4

8‒16

≥ 32

0

3.15

96.85

 Linezolid

1‒32

16

> 32

≤ 8

16

≥ 32

33.07

32.28

34.6

 Cefoxitin

4‒128

64

128

≤ 16

32‒64

≥ 128

6.30

74.8

18.90

 Tobramycin

1‒16

8

> 16

≤ 2

4

≥ 8

13.39

12.60

74.02

 Doxycycline

0.12‒16

> 16

> 16

≤ 1

2‒4

≥ 8

4.72

0

95.28

 Moxifloxacin

0.25‒8

8

> 8

≤ 1

2

≥ 4

7.81

1.56

90.63

 Ciprofloxacin

0.12‒4

> 4

> 4

≤ 1

2

≥ 4

11.02

0.79

88.19

 Tigecycline

0.015‒4

1

2

-

-

-

-

-

-

 TMP‒SMX

0.25/4.75‒8/152

> 8/152

> 8/152

≤ 2/38

-

≥ 4/76

4.72

-

95.28

  1. NTM nontuberculous mycobacteria, RGM rapid growing mycobacteria, SGM slow growing mycobacteria, TMP‒SMX trimethoprim-sulfamethoxazole
  2. aCLSI M24, 3rd ed. 2018 (2)