Skip to main content

Table 2 Susceptibility of RGM to antimicrobial agents determined by the broth dilution method

From: Nontuberculous mycobacteria in China: incidence and antimicrobial resistance spectrum from a nationwide survey

Grouping/species RGM (n = 128)
Antimicrobial agent Broth dilution ranges (μg/ml) MIC50 MIC90 Susceptible Intermediate Resistant S (%) I (%) R (%)
Antimicrobial agents and susceptibility breakpoints (MICs) for testing rapidly growing mycobacteriaa
 Amikacin 1‒64 8 16 ≤ 16 32 ≥ 64 93.75 1.56 4.69
  Clarithromycin (3D) 0.06‒16 0.12 8 ≤ 2 4 ≥ 8 85.04 0 14.96
 Clarithromycin (14D) 8 > 16 44.09 2.36 53.5
 Imipenem 2‒64 > 64 > 64 ≤ 4 8‒16 ≥ 32 0 3.15 96.85
 Linezolid 1‒32 16 > 32 ≤ 8 16 ≥ 32 33.07 32.28 34.6
 Cefoxitin 4‒128 64 128 ≤ 16 32‒64 ≥ 128 6.30 74.8 18.90
 Tobramycin 1‒16 8 > 16 ≤ 2 4 ≥ 8 13.39 12.60 74.02
 Doxycycline 0.12‒16 > 16 > 16 ≤ 1 2‒4 ≥ 8 4.72 0 95.28
 Moxifloxacin 0.25‒8 8 > 8 ≤ 1 2 ≥ 4 7.81 1.56 90.63
 Ciprofloxacin 0.12‒4 > 4 > 4 ≤ 1 2 ≥ 4 11.02 0.79 88.19
 Tigecycline 0.015‒4 1 2 - - - - - -
 TMP‒SMX 0.25/4.75‒8/152 > 8/152 > 8/152 ≤ 2/38 - ≥ 4/76 4.72 - 95.28
  1. NTM nontuberculous mycobacteria, RGM rapid growing mycobacteria, SGM slow growing mycobacteria, TMP‒SMX trimethoprim-sulfamethoxazole
  2. aCLSI M24, 3rd ed. 2018 (2)