Nontuberculous mycobacteria in China: incidence and antimicrobial resistance spectrum from a nationwide survey

Table 4 Susceptibility of MAC to antimicrobial agents determined by the broth dilution method

Grouping/species	Mycobacterium avium‒intracellulare complex (n = 108)
Antimicrobial agent	Broth dilution range (μg/ml)	MIC50	MIC90	Susceptible	Intermediate	Resistant	S (%)	I (%)	R (%)
Antimicrobial agents and susceptibility breakpoints (MICs) for testing MAC^a
First line
Clarithromycin	0.06‒64	2	4	≤ 8	16	≥ 32	95.37	0	4.63
Amikacin	1‒64	16	64	≤ 16	32	≥ 64	71.30	18.52	10.19
Second line
Linezolid	1‒64	32	64	≤ 8	16	≥ 32	14.81	18.52	66.67
Moxifloxacin	0.12‒8	2	8	≤ 1	2	≥ 4	15.74	37.04	47.22

MAC mycobacterium avium‒intracellulare complex, CLSI Clinical and Laboratory Standards Institute
^aCLSI M24, 3rd ed., 2018 (2)

ISSN: 2049-9957