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Table 5 Susceptibility of Mycobacterium kansasii to antimicrobial agents determined by the broth dilution method

From: Nontuberculous mycobacteria in China: incidence and antimicrobial resistance spectrum from a nationwide survey

Grouping/species

M. Kansasii (n = 31)

Antimicrobial agent

Broth dilution ranges (μg/ml)

MIC50

MIC90

Susceptible

Intermediate

Resistant

S (%)

I (%)

R (%)

Antimicrobial agents and susceptibility breakpoints (MICs) for testing M. kansasiia

First line

  Clarithromycin

0.06‒64

0.25

0.5

≤ 8

16

≥ 32

100

0

0

  Rifampicin

0.12‒8

0.5

0.5

≤ 1

-

≥ 2

93.55

-

6.45

 Second line

  Amikacin

1‒64

2

8

≤ 16

32

≥ 64

96.77

3.23

0

  Ciprofloxacin

0.12‒16

2

4

≤ 1

2

≥ 4

32.26

41.93

25.81

  Doxycycline

0.12‒16

8

16

≤ 1

2‒4

≥ 8

9.68

12.90

77.42

  Linezolid

1‒64

2

4

≤ 8

16

≥ 32

96.77

0

3.23

  Moxifloxacin

0.12‒8

≤ 0.12

0.25

≤ 1

2

≥ 4

96.77

3.23

0

  Rifabutin

0.25‒8

≤ 0.25

0.5

≤ 2

-

≥ 4

96.77

0

3.23

  TMP‒SMX

0.12/2.38‒8/152

4/76

> 8/152

≤ 2/38

-

≥ 4/76

48.39

-

51.61

  1. TMP‒SMX trimethoprim-sulfamethoxazole, CLSI Clinical and Laboratory Standards Institute
  2. aCLSI M24, 3rd ed. 2018 (2)