Table 5 Performance of CareStart G6PD biosensor against genotyping
From: Assessment of CareStart G6PD rapid diagnostic test and CareStart G6PD biosensor in Mauritania
Performance | Cut-off levels | ||
|---|---|---|---|
< 10% | < 30% | < 80% | |
Cut-off value (IU/g Hb) | 0.53 | 1.60 | 4.27 |
All patients except AA- and BA- females | |||
n (%) | 8 (2.7) | 30 (10.2) | 108 (36.6) |
Sensitivity (%; 95% CI) | 57.1 (18.4–90.1) | 85.7 (42.1–99.6) | 100 (59.0–100) |
Specificity (%; 95% CI) | 98.6 (96.5–99.6) | 91.7 (87.8–94.6) | 64.9 (59.1–70.4) |
Positive predictive value (%; 95% CI) | 50.0 (23.8–76.2) | 20.0 (13.3–28.9) | 6.5(5.6–7.5) |
Negative predictive value (%; 95% CI) | 99.0 (97.6–99.6) | 99.6 (97.7–99.9) | 100 |
Patients without severe anaemia* | |||
n (%) | 7 (2.6) | 27 (9.9) | 102 (37.4) |
Sensitivity (%; 95% CI) | 50.0 (11.8–88.2) | 83.3 (35.9–99.6) | 100 (54.1–100) |
Specificity (%; 95% CI) | 98.5 (96.2–99.6) | 91.8 (87.8–94.8) | 64.0 (58.0–69.8) |
Positive predictive value (%; 95% CI) | 42.9 (17.6–72.6) | 18.5 (11.7–28.0) | 5.9 (5.1–6.8) |
Negative predictive value (%; 95% CI) | 98.9 (97.5–99.5) | 99.6 (97.6–99.9) | 100 |