Table 2 Quantitative monitoring of SARS-CoV-2 strains with specific mutations
Mutant strains | Collected locations | Onset date† | Numbers before onset (%§) | Numbers till deadline# (%§) | P* |
|---|---|---|---|---|---|
(total numbers) | |||||
E484K | USA | 2020/8/10 | 15/60 253 (0.02) | 37 830/519 493 (7.28) | < 0.001 |
(86 585) | Brazil | 2020/10/14 | 15/3104 (0.48) | 8001/12 725 (62.88) | < 0.001 |
Japan | 2020/12/8 | 16/17 633 (0.09) | 5849/46 122 (12.68) | < 0.001 | |
Germany | 2020/12/28 | 15/7313 (0.21) | 3679/119 793 (3.07) | 1.67E−73 | |
France | 2021/1/6 | 19/5299 (0.36) | 3114/37 205 (8.37) | 2.72E−155 | |
South Africa | 2020/10/10 | 15/2451 (0.61) | 2675/6329 (42.27) | < 0.001 | |
Sweden | 2021/1/18 | 15/3656 (0.41) | 2351/54 991 (4.28) | 6.95E−47 | |
Belgium | 2021/1/10 | 16/3952 (0.4) | 2187/22 666 (9.65) | 8.51E−133 | |
United Kingdom | 2020/12/12 | 16/145 591 (0.01) | 2071/421 559 (0.49) | 1.81E−237 | |
Canada | 2020/12/14 | 20/16 160 (0.12) | 1644/27 996 (5.87) | 4.20E−296 | |
S477N** | USA | 2020/8/21 | 15/63 825 (0.02) | 12 772/519 495 (2.46) | < 0.001 |
(55 442) | Australia | 2020/5/28 | 17/3447 (0.49) | 10 090/17 811 (56.65) | < 0.001 |
Denmark | 2020/8/17 | 33/3015 (1.09) | 6194/101 999 (6.07) | 6.24E−43 | |
Switzerland | 2020/8/24 | 16/2422 (0.66) | 5701/40 653 (14.02) | 1.16E−126 | |
France | 2020/7/29 | 19/2537 (0.75) | 3853/37 205 (10.36) | 1.64E−87 | |
United Kingdom | 2020/4/12 | 15/20 890 (0.07) | 3318/421 559 (0.79) | 2.10E−49 | |
Germany | 2020/9/10 | 15/3474 (0.43) | 3191/119 797 (2.66) | 3.40E−23 | |
Luxembourg | 2020/10/7 | 15/423 (3.55) | 1445/8248 (17.52) | 4.51E−18 | |
Sweden | 2020/8/11 | 16/876 (1.83) | 1232/54 991 (2.24) | 0.488828411 | |
Belgium | 2020/9/15 | 22/1862 (1.18) | 1229/22 666 (5.42) | < 0.001 | |
T478K | USA | 2020/11/23 | 16/43 020 (0.04) | 13 072/519 493 (2.52) | < 0.001 |
(31 516) | United Kingdom | 2020/12/31 | 15/172 126 (0.01) | 10 085/421 559 (2.39) | < 0.001 |
Mexico | 2020/11/30 | 17/2845 (0.6) | 4876/14 372 (33.93) | < 0.001 | |
India | 2021/3/1 | 16/11 429 (0.14) | 1719/22 009 (7.81) | 7.92E−292 | |
Germany | 2021/2/4 | 16/16 175 (0.1) | 566/119 793 (0.47) | 1.56E−15 | |
Canada | 2021/1/19 | 16/19 501 (0.08) | 374/27 996 (1.34) | 4.64E−65 | |
Denmark | 2021/4/5 | 15/79 383 (0.02) | 258/101 999 (0.25) | 2.80E−46 | |
Switzerland | 2020/12/25 | 17/12 385 (0.14) | 244/40 653 (0.6) | 6.06E−13 | |
Sweden | 2021/1/25 | 17/4328 (0.39) | 182/54 991 (0.33) | 0.493286089 | |
Japan | 2021/4/16 | 18/40 879 (0.04) | 154/46 122 (0.33) | 9.30E−25 | |
N439K | Denmark | 2020/8/24 | 21/3277 (0.64) | 5599/101 999 (5.49) | 1.46E−51 |
(27 987) | Slovenia | 2020/8/15 | 16/350 (4.57) | 4555/11 747 (38.78) | 4.87E−50 |
United Kingdom | 2020/3/24 | 16/8202 (0.2) | 4459/421 559 (1.06) | 3.11E−20 | |
Germany | 2020/8/25 | 15/3338 (0.45) | 3217/119 793 (2.69) | 3.83E−22 | |
Sweden | 2020/11/23 | 16/1325 (1.21) | 1459/54 991 (2.65) | 0.000464083 | |
Switzerland | 2020/8/21 | 15/2355 (0.64) | 1334/40 653 (3.28) | 2.11E−17 | |
Austria | 2020/11/2 | 18/1085 (1.66) | 1302/15 060 (8.65) | 1.29E−21 | |
Italy | 2020/10/14 | 15/2291 (0.65) | 972/28 589 (3.4) | 1.97E−17 | |
Netherlands | 2020/10/15 | 18/3257 (0.55) | 468/33 758 (1.39) | 1.63E−05 | |
Indonesia | 2020/12/30 | 19/623 (3.05) | 467/1773 (26.34) | 2.40E−45 | |
S494P | USA | 2020/7/18 | 15/52 902 (0.03) | 6420/519 493 (1.24) | 8.00E−243 |
(8638) | United Kingdom | 2020/8/14 | 15/49 206 (0.03) | 937/421 559 (0.22) | 1.60E−27 |
Spain | 2020/12/20 | 15/9540 (0.16) | 376/29 902 (1.26) | 1.90E−28 | |
Germany | 2021/2/5 | 18/16 737 (0.11) | 150/119 793 (0.13) | 0.637633683 | |
A520S** | USA | 2020/6/9 | 21/35 378 (0.06) | 2867/519 493 (0.55) | 8.67E−55 |
(4113) | United Kingdom | 2020/6/24 | 16/43 220 (0.04) | 238/421 559 (0.06) | 0.105089403 |
Denmark | 2020/8/31 | 91/3996 (2.28) | 199/101 999 (0.2) | 7.18E−57 | |
F490S | Denmark | 2021/3/29 | 25/76 052 (0.03) | 650/101 999 (0.64) | 5.25E−122 |
(3954) | USA | 2020/12/7 | 15/109 237 (0.01) | 632/519 493 (0.12) | 2.62E−34 |
Germany | 2021/2/22 | 17/27 057 (0.06) | 601/119 793 (0.5) | 2.88E−33 | |
United Kingdom | 2020/12/15 | 15/150 582 (0.01) | 418/421 559 (0.1) | 3.21E−37 | |
Israel | 2021/1/7 | 18/2706 (0.67) | 378/11 835 (3.19) | 6.52E−17 | |
Chile | 2021/3/7 | 15/1454 (1.03) | 273/2193 (12.45) | 6.14E−45 | |
Poland | 2021/3/3 | 15/2917 (0.51) | 267/12 832 (2.08) | 1.04E−10 | |
Argentina | 2021/2/26 | 16/2115 (0.76) | 136/3148 (4.32) | 2.71E−16 | |
Netherlands | 2021/3/31 | 18/23 847 (0.08) | 116/33 758 (0.34) | 2.98E−12 | |
N501T** | USA | 2020/8/28 | 15/65 569 (0.02) | 2339/519 494 (0.45) | 2.85E−97 |
(3288) | France | 2021/1/9 | 23/5626 (0.41) | 200/37 177 (0.54) | 0.233423368 |
Australia | 2020/12/16 | 15/16 685 (0.09) | 170/17 811 (0.95) | 1.47E−32 | |
A522S** | Germany | 2020/12/10 | 15/6881 (0.22) | 846/119 793 (0.71) | 6.05E−08 |
(3275) | USA | 2020/8/26 | 16/65 058 (0.02) | 654/519 493 (0.13) | 2.63E−17 |
France | 2021/1/27 | 23/7974 (0.29) | 344/37 205 (0.92) | 2.22E−10 | |
Denmark | 2020/11/23 | 35/12 200 (0.29) | 231/101 999 (0.23) | 0.19572294 | |
United Kingdom | 2020/8/31 | 20/54 038 (0.04) | 231/421 559 (0.05) | 0.091287615 | |
Russia | 2020/11/9 | 17/1896 (0.9) | 182/3962 (4.59) | 1.05E−15 | |
Italy | 2021/3/13 | 16/15 095 (0.11) | 147/28 589 (0.51) | 3.09E−13 | |
Austria | 2021/1/18 | 19/2638 (0.72) | 122/15 060 (0.81) | 0.722036891 | |
V367F** | United Kingdom | 2020/4/17 | 15/24 276 (0.06) | 391/421 559 (0.09) | 0.126000419 |
(1886) | USA | 2020/6/1 | 15/33 267 (0.05) | 358/519 493 (0.07) | 0.125838334 |
Canada | 2021/1/2 | 17/17 660 (0.1) | 275/27 996 (0.98) | 5.81E−39 | |
Uganda | 2020/8/15 | 22/95 (23.16) | 220/428 (51.4) | 4.08E−07 | |
A522V** | USA | 2020/7/13 | 15/51 506 (0.03) | 365/519 493 (0.07) | 0.000214014 |
(1012) | United Kingdom | 2020/4/7 | 15/17 505 (0.09) | 197/421 559 (0.05) | 0.03237495 |