|
Mutant strains
|
Collected locations
|
Onset date†
|
Numbers before onset (%§)
|
Numbers till deadline# (%§)
|
P*
|
|---|
|
(total numbers)
|
|---|
|
E484K
|
USA
|
2020/8/10
|
15/60 253 (0.02)
|
37 830/519 493 (7.28)
|
< 0.001
|
|
(86 585)
|
Brazil
|
2020/10/14
|
15/3104 (0.48)
|
8001/12 725 (62.88)
|
< 0.001
|
| |
Japan
|
2020/12/8
|
16/17 633 (0.09)
|
5849/46 122 (12.68)
|
< 0.001
|
| |
Germany
|
2020/12/28
|
15/7313 (0.21)
|
3679/119 793 (3.07)
|
1.67E−73
|
| |
France
|
2021/1/6
|
19/5299 (0.36)
|
3114/37 205 (8.37)
|
2.72E−155
|
| |
South Africa
|
2020/10/10
|
15/2451 (0.61)
|
2675/6329 (42.27)
|
< 0.001
|
| |
Sweden
|
2021/1/18
|
15/3656 (0.41)
|
2351/54 991 (4.28)
|
6.95E−47
|
| |
Belgium
|
2021/1/10
|
16/3952 (0.4)
|
2187/22 666 (9.65)
|
8.51E−133
|
| |
United Kingdom
|
2020/12/12
|
16/145 591 (0.01)
|
2071/421 559 (0.49)
|
1.81E−237
|
| |
Canada
|
2020/12/14
|
20/16 160 (0.12)
|
1644/27 996 (5.87)
|
4.20E−296
|
|
S477N**
|
USA
|
2020/8/21
|
15/63 825 (0.02)
|
12 772/519 495 (2.46)
|
< 0.001
|
|
(55 442)
|
Australia
|
2020/5/28
|
17/3447 (0.49)
|
10 090/17 811 (56.65)
|
< 0.001
|
| |
Denmark
|
2020/8/17
|
33/3015 (1.09)
|
6194/101 999 (6.07)
|
6.24E−43
|
| |
Switzerland
|
2020/8/24
|
16/2422 (0.66)
|
5701/40 653 (14.02)
|
1.16E−126
|
| |
France
|
2020/7/29
|
19/2537 (0.75)
|
3853/37 205 (10.36)
|
1.64E−87
|
| |
United Kingdom
|
2020/4/12
|
15/20 890 (0.07)
|
3318/421 559 (0.79)
|
2.10E−49
|
| |
Germany
|
2020/9/10
|
15/3474 (0.43)
|
3191/119 797 (2.66)
|
3.40E−23
|
| |
Luxembourg
|
2020/10/7
|
15/423 (3.55)
|
1445/8248 (17.52)
|
4.51E−18
|
| |
Sweden
|
2020/8/11
|
16/876 (1.83)
|
1232/54 991 (2.24)
|
0.488828411
|
| |
Belgium
|
2020/9/15
|
22/1862 (1.18)
|
1229/22 666 (5.42)
|
< 0.001
|
|
T478K
|
USA
|
2020/11/23
|
16/43 020 (0.04)
|
13 072/519 493 (2.52)
|
< 0.001
|
|
(31 516)
|
United Kingdom
|
2020/12/31
|
15/172 126 (0.01)
|
10 085/421 559 (2.39)
|
< 0.001
|
| |
Mexico
|
2020/11/30
|
17/2845 (0.6)
|
4876/14 372 (33.93)
|
< 0.001
|
| |
India
|
2021/3/1
|
16/11 429 (0.14)
|
1719/22 009 (7.81)
|
7.92E−292
|
| |
Germany
|
2021/2/4
|
16/16 175 (0.1)
|
566/119 793 (0.47)
|
1.56E−15
|
| |
Canada
|
2021/1/19
|
16/19 501 (0.08)
|
374/27 996 (1.34)
|
4.64E−65
|
| |
Denmark
|
2021/4/5
|
15/79 383 (0.02)
|
258/101 999 (0.25)
|
2.80E−46
|
| |
Switzerland
|
2020/12/25
|
17/12 385 (0.14)
|
244/40 653 (0.6)
|
6.06E−13
|
| |
Sweden
|
2021/1/25
|
17/4328 (0.39)
|
182/54 991 (0.33)
|
0.493286089
|
| |
Japan
|
2021/4/16
|
18/40 879 (0.04)
|
154/46 122 (0.33)
|
9.30E−25
|
|
N439K
|
Denmark
|
2020/8/24
|
21/3277 (0.64)
|
5599/101 999 (5.49)
|
1.46E−51
|
|
(27 987)
|
Slovenia
|
2020/8/15
|
16/350 (4.57)
|
4555/11 747 (38.78)
|
4.87E−50
|
| |
United Kingdom
|
2020/3/24
|
16/8202 (0.2)
|
4459/421 559 (1.06)
|
3.11E−20
|
| |
Germany
|
2020/8/25
|
15/3338 (0.45)
|
3217/119 793 (2.69)
|
3.83E−22
|
| |
Sweden
|
2020/11/23
|
16/1325 (1.21)
|
1459/54 991 (2.65)
|
0.000464083
|
| |
Switzerland
|
2020/8/21
|
15/2355 (0.64)
|
1334/40 653 (3.28)
|
2.11E−17
|
| |
Austria
|
2020/11/2
|
18/1085 (1.66)
|
1302/15 060 (8.65)
|
1.29E−21
|
| |
Italy
|
2020/10/14
|
15/2291 (0.65)
|
972/28 589 (3.4)
|
1.97E−17
|
| |
Netherlands
|
2020/10/15
|
18/3257 (0.55)
|
468/33 758 (1.39)
|
1.63E−05
|
| |
Indonesia
|
2020/12/30
|
19/623 (3.05)
|
467/1773 (26.34)
|
2.40E−45
|
|
S494P
|
USA
|
2020/7/18
|
15/52 902 (0.03)
|
6420/519 493 (1.24)
|
8.00E−243
|
|
(8638)
|
United Kingdom
|
2020/8/14
|
15/49 206 (0.03)
|
937/421 559 (0.22)
|
1.60E−27
|
| |
Spain
|
2020/12/20
|
15/9540 (0.16)
|
376/29 902 (1.26)
|
1.90E−28
|
| |
Germany
|
2021/2/5
|
18/16 737 (0.11)
|
150/119 793 (0.13)
|
0.637633683
|
|
A520S**
|
USA
|
2020/6/9
|
21/35 378 (0.06)
|
2867/519 493 (0.55)
|
8.67E−55
|
|
(4113)
|
United Kingdom
|
2020/6/24
|
16/43 220 (0.04)
|
238/421 559 (0.06)
|
0.105089403
|
| |
Denmark
|
2020/8/31
|
91/3996 (2.28)
|
199/101 999 (0.2)
|
7.18E−57
|
|
F490S
|
Denmark
|
2021/3/29
|
25/76 052 (0.03)
|
650/101 999 (0.64)
|
5.25E−122
|
|
(3954)
|
USA
|
2020/12/7
|
15/109 237 (0.01)
|
632/519 493 (0.12)
|
2.62E−34
|
| |
Germany
|
2021/2/22
|
17/27 057 (0.06)
|
601/119 793 (0.5)
|
2.88E−33
|
| |
United Kingdom
|
2020/12/15
|
15/150 582 (0.01)
|
418/421 559 (0.1)
|
3.21E−37
|
| |
Israel
|
2021/1/7
|
18/2706 (0.67)
|
378/11 835 (3.19)
|
6.52E−17
|
| |
Chile
|
2021/3/7
|
15/1454 (1.03)
|
273/2193 (12.45)
|
6.14E−45
|
| |
Poland
|
2021/3/3
|
15/2917 (0.51)
|
267/12 832 (2.08)
|
1.04E−10
|
| |
Argentina
|
2021/2/26
|
16/2115 (0.76)
|
136/3148 (4.32)
|
2.71E−16
|
| |
Netherlands
|
2021/3/31
|
18/23 847 (0.08)
|
116/33 758 (0.34)
|
2.98E−12
|
|
N501T**
|
USA
|
2020/8/28
|
15/65 569 (0.02)
|
2339/519 494 (0.45)
|
2.85E−97
|
|
(3288)
|
France
|
2021/1/9
|
23/5626 (0.41)
|
200/37 177 (0.54)
|
0.233423368
|
| |
Australia
|
2020/12/16
|
15/16 685 (0.09)
|
170/17 811 (0.95)
|
1.47E−32
|
|
A522S**
|
Germany
|
2020/12/10
|
15/6881 (0.22)
|
846/119 793 (0.71)
|
6.05E−08
|
|
(3275)
|
USA
|
2020/8/26
|
16/65 058 (0.02)
|
654/519 493 (0.13)
|
2.63E−17
|
| |
France
|
2021/1/27
|
23/7974 (0.29)
|
344/37 205 (0.92)
|
2.22E−10
|
| |
Denmark
|
2020/11/23
|
35/12 200 (0.29)
|
231/101 999 (0.23)
|
0.19572294
|
| |
United Kingdom
|
2020/8/31
|
20/54 038 (0.04)
|
231/421 559 (0.05)
|
0.091287615
|
| |
Russia
|
2020/11/9
|
17/1896 (0.9)
|
182/3962 (4.59)
|
1.05E−15
|
| |
Italy
|
2021/3/13
|
16/15 095 (0.11)
|
147/28 589 (0.51)
|
3.09E−13
|
| |
Austria
|
2021/1/18
|
19/2638 (0.72)
|
122/15 060 (0.81)
|
0.722036891
|
|
V367F**
|
United Kingdom
|
2020/4/17
|
15/24 276 (0.06)
|
391/421 559 (0.09)
|
0.126000419
|
|
(1886)
|
USA
|
2020/6/1
|
15/33 267 (0.05)
|
358/519 493 (0.07)
|
0.125838334
|
| |
Canada
|
2021/1/2
|
17/17 660 (0.1)
|
275/27 996 (0.98)
|
5.81E−39
|
| |
Uganda
|
2020/8/15
|
22/95 (23.16)
|
220/428 (51.4)
|
4.08E−07
|
|
A522V**
|
USA
|
2020/7/13
|
15/51 506 (0.03)
|
365/519 493 (0.07)
|
0.000214014
|
|
(1012)
|
United Kingdom
|
2020/4/7
|
15/17 505 (0.09)
|
197/421 559 (0.05)
|
0.03237495
|
- *Fisher's exact test was used to compare proportion of mutant strains among all uploaded isolates which were collected between before onset date and till deadline
- **These mutations are with increasing predicted affinity to receptor
- †The onset date listed in the table was the time when more than 15 mutants were uploaded locally
- §Proportion referred to the ratio of numbers of specific mutations among all uploaded sequences
- #Deadline referred to 30 May, 2021
