|
Diagnostic test
|
KK (+) Moderate
|
KK (+) Light§
|
KK (−)
|
Entire cohort
|
|---|
|
(EPG: 100–399)
|
(EPG: 10–99)
|
(EPG: 1–9)
|
(EPG: 0)
|
(EPG: 0–399)
|
|---|
|
Positive, % (n/n)
|
Positive, % (n/n)
|
P*
|
Positive, % (n/n)
|
P*
|
Positive, % (n/n)
|
P*
|
Prevalence, % (n/n)
|
P*
|
|---|
|
POC-CCA†
|
100 (4/4)
|
57.7 (15/26)
| |
16.7 (13/78)
| |
6.3 (19/304)
| |
12.4 (51/412)
| |
|
F_ddPCR
|
100 (4/4)
|
100 (26/26)
|
0.0026
|
97.4 (76/78)
|
< 0.0001
|
66.1 (201/304)
|
< 0.0001
|
74.5 (307/412)
|
< 0.0001
|
|
SR_ddPCR
|
100 (4/4)
|
100 (26/26)
|
0.0026
|
92.3 (72/78)
|
< 0.0001
|
57.6 (175/304)
|
< 0.0001
|
67.2 (277/412)
|
< 0.0001
|
|
U_ddPCR
|
100 (4/4)
|
88.5 (23/26)
|
0.0269
|
47.4 (37/78)
|
0.0004
|
43.4 (132/304)
|
< 0.0001
|
47.6 (196/412)
|
< 0.0001
|
|
SL_ddPCR
|
100 (4/4)
|
76.9 (20/26)
|
>0.05
|
23.1 (18/78)
|
>0.05
|
20.4 (62/304)
|
< 0.0001
|
25.5 (105/412)
|
< 0.0001
|
|
Sj23-LHD-ELISA#
|
100 (4/4)
|
53.8 (14/26)
|
>0.05
|
61.5 (48/78)
|
< 0.0001
|
18.1 (55/304)
|
< 0.0001
|
30.6 (126/412)
|
< 0.0001
|
|
SjSAP4-ELISA#
|
100 (4/4)
|
92.3 (24/26)
|
0.0159
|
91.0 (71/78)
|
< 0.0001
|
56.3 (171/304)
|
< 0.0001
|
65.5 (270/412)
|
< 0.0001
|
- ddPCR Droplet digital PCR; The ddPCRs performed on faeces, serum, urine and saliva were designated as F_ddPCR, SR_ddPCR, U_ddPCR and SL_ddPCR, respectively. ELISA Enzyme-linked immunosorbent assay, EPG Eggs per gram of faeces, KK Kato-Katz; POC-CCA Point-of-care circulating cathodic antigen
- §Individuals with a light infection were categorised into two subgroups with EPG of 10–99 and 1–9
- *P values were determined by McNemar's test
- †R cut-off value: 0.1344
- #Cut-off values for ELISA assays: Sj23-LHD-ELISA, 0.2185; SjSAP4-ELISA, 0.1832 [25]
