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Table 2 Positivity rates and prevalences determined by different diagnostic tests across the different groups stratified by parasite burden and in the entire cohort

From: Performance of the point-of-care circulating cathodic antigen test in the diagnosis of schistosomiasis japonica in a human cohort from Northern Samar, the Philippines

Diagnostic test KK (+) Moderate KK (+) Light§ KK (−) Entire cohort
(EPG: 100–399) (EPG: 10–99) (EPG: 1–9) (EPG: 0) (EPG: 0–399)
Positive, % (n/n) Positive, % (n/n) P* Positive, % (n/n) P* Positive, % (n/n) P* Prevalence, % (n/n) P*
POC-CCA 100 (4/4) 57.7 (15/26)   16.7 (13/78)   6.3 (19/304)   12.4 (51/412)  
F_ddPCR 100 (4/4) 100 (26/26) 0.0026 97.4 (76/78)  < 0.0001 66.1 (201/304)  < 0.0001 74.5 (307/412)  < 0.0001
SR_ddPCR 100 (4/4) 100 (26/26) 0.0026 92.3 (72/78)  < 0.0001 57.6 (175/304)  < 0.0001 67.2 (277/412)  < 0.0001
U_ddPCR 100 (4/4) 88.5 (23/26) 0.0269 47.4 (37/78) 0.0004 43.4 (132/304)  < 0.0001 47.6 (196/412)  < 0.0001
SL_ddPCR 100 (4/4) 76.9 (20/26) >0.05 23.1 (18/78) >0.05 20.4 (62/304)  < 0.0001 25.5 (105/412)  < 0.0001
Sj23-LHD-ELISA# 100 (4/4) 53.8 (14/26) >0.05 61.5 (48/78)  < 0.0001 18.1 (55/304)  < 0.0001 30.6 (126/412)  < 0.0001
SjSAP4-ELISA# 100 (4/4) 92.3 (24/26) 0.0159 91.0 (71/78)  < 0.0001 56.3 (171/304)  < 0.0001 65.5 (270/412)  < 0.0001
  1. ddPCR Droplet digital PCR; The ddPCRs performed on faeces, serum, urine and saliva were designated as F_ddPCR, SR_ddPCR, U_ddPCR and SL_ddPCR, respectively. ELISA Enzyme-linked immunosorbent assay, EPG Eggs per gram of faeces, KK Kato-Katz; POC-CCA Point-of-care circulating cathodic antigen
  2. §Individuals with a light infection were categorised into two subgroups with EPG of 10–99 and 1–9
  3. *P values were determined by McNemar's test
  4. R cut-off value: 0.1344
  5. #Cut-off values for ELISA assays: Sj23-LHD-ELISA, 0.2185; SjSAP4-ELISA, 0.1832 [25]