Skip to main content

Table 3 Performance of the POC-CCA assay using different diagnostic tests as reference

From: Performance of the point-of-care circulating cathodic antigen test in the diagnosis of schistosomiasis japonica in a human cohort from Northern Samar, the Philippines

POC-CCA†

Reference test

Sensitivity, % (95% CI)

Specificity, % (95% CI)

PPV, % (95% CI)

NPV, % (95% CI)

Accuracy, % (95% CI)

Kappa index (95% CI)

+ 

−

 

KK

+ 

32

19

29.6 (21.2–39.2)

93.8 (90.4–96.2)

62.8 (48.1–75.9)

79.0 (74.4–83.0)

77.0 (72.6–81.0)

0.282 (0.179–0.385)

−

76

285

 

F_ddPCR

+ 

44

7

14.3 (10.6–18.8)

93.3 (86.8–97.3)

86.3 (73.7–94.3)

27.2 (22.6–32.1)

34.5 (29.9–39.3)

0.043 (0.007–0.078)

−

263

98

 

SR_ddPCR

+ 

41

10

14.8 (10.8–19.5)

92.6 (86.8–96.4)

80.4 (66.9–90.2)

34.6 (29.7–39.8)

40.1 (35.5–45.2)

0.052 (0.008–0.095)

−

236

125

 

U_ddPCR

+ 

31

20

15.8 (11.0–21.7)

90.7 (86.1–94.3)

60.8 (46.1–74.2)

54.3 (49.0–59.5)

55.1 (50.2–60.0)

0.068 (0.001–0.134)

−

165

196

 

SL_ddPCR

+ 

29

22

27.6 (19.3–37.2)

92.8 (89.4–95.5)

56.9 (42.3–71.0)

79.0 (74.4–83.0)

76.2 (71.8–80.3)

0.246 (0.142–0.350)

−

76

285

 

Sj23-LHD-ELISA#

+ 

23

28

22.3 (14.7–31.6)

91.0 (89.4–95.5)

45.1 (31.1–59.7)

77.8 (73.2–82.0)

73.8 (69.3–78.0)

0.160 (0.058–0.261)

−

80

281

 

SjSAP4-ELISA#

+ 

41

10

15.6 (11.4–20.6)

93.3 (88.0–96.7)

80.4 (66.9–90.2)

38.5 (33.5–43.7)

43.7 (38.8–48.6)

0.068 (0.021–0.114)

−

222

139

  1. CI Confidence interval, ddPCR Droplet digital PCR, The ddPCRs performed on faeces, serum, urine and saliva were designated as F_ddPCR, SR_ddPCR, U_ddPCR and SL_ddPCR, respectively. ELISA Enzyme-linked immunosorbent assay, KK Kato-Katz, POC-CCA Point-of-care circulating cathodic antigen, NPV Negative predictive value, PPV Positive predictive value.
  2. †R cut-off value: 0.1344
  3. #Cut-off values for ELISA assays: Sj23-LHD-ELISA, 0.2185; SjSAP4-ELISA, 0.1832 [25]
Back to article page

Infectious Diseases of Poverty

ISSN: 2049-9957

Contact us