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Table 1 Dengue severity stratification according to 1997 and 2009 World Health Organization (WHO) guidelines

From: Clinical predictors of severe dengue: a systematic review and meta-analysis

1997 WHO classification

2009 WHO classification

Dengue fever

DHF (Grade 1 and 2)

DSS (Grade 3 and 4)

DWoWS

DWWS

SD

Acute febrile illness with ≥ 2 of the following symptoms:

 Headache

 Retro-orbital pain

 Myalgia

 Arthralgia

 Rash

Haemorrhage manifestations

 Leukopenia

Following must be all present:

 Fever or history of fever

 Haemorrhage tendencies (as manifested by a positive tourniquet test, petechiae/purpura/ecchymoses, mucosal bleeding)

 Thrombocytopenia

 Plasma leakage (a rise in the haematocrit, pleural effusion, ascites)

All four criteria of DHF plus evidence of circulatory failure evidenced by:

 Rapid and weak pulse

 Narrow pulse pressure (< 20 mm Hg)

 Hypotension

 Cold clammy skin and restlessness

Fever and two of the following symptoms:

 Nausea or vomiting

 Rash

 Bodyaches

 Positive tourniquet test

 Leukopenia

Similar features of DWoWS with the following warning signs:

 Abdominal pain

 Persistent vomiting

 Lethargy or restlessness

 Liver enlargement

 Increase in HCT and decrease in platelet count

Patients with any of the following features:

 Severe plasma leakage leading to Shock, fluid accumulation with respiratory distress

 Severe bleeding

 Severe organ impairment

  1. DHF dengue haemorrhagic fever, DSS dengue shock syndrome, DWoWS dengue without warning signs, DWWS dengue with warning signs, SD severe dengue, HCT haematocrit
  2. *Case definition of severe dengue used in the meta-analysis is shaded in grey