From: Clinical predictors of severe dengue: a systematic review and meta-analysis
1997 WHO classification | 2009 WHO classification | ||||
---|---|---|---|---|---|
Dengue fever | DHF (Grade 1 and 2) | DSS (Grade 3 and 4) | DWoWS | DWWS | SD |
Acute febrile illness with ≥ 2 of the following symptoms:  Headache  Retro-orbital pain  Myalgia  Arthralgia  Rash Haemorrhage manifestations  Leukopenia | Following must be all present:  Fever or history of fever  Haemorrhage tendencies (as manifested by a positive tourniquet test, petechiae/purpura/ecchymoses, mucosal bleeding)  Thrombocytopenia  Plasma leakage (a rise in the haematocrit, pleural effusion, ascites) | All four criteria of DHF plus evidence of circulatory failure evidenced by:  Rapid and weak pulse  Narrow pulse pressure (< 20 mm Hg)  Hypotension  Cold clammy skin and restlessness | Fever and two of the following symptoms:  Nausea or vomiting  Rash  Bodyaches  Positive tourniquet test  Leukopenia | Similar features of DWoWS with the following warning signs:  Abdominal pain  Persistent vomiting  Lethargy or restlessness  Liver enlargement  Increase in HCT and decrease in platelet count | Patients with any of the following features:  Severe plasma leakage leading to Shock, fluid accumulation with respiratory distress  Severe bleeding  Severe organ impairment |