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Table 1 Promising progress towards the development of live attenuated vaccines against African swine fever

From: Current efforts towards safe and effective live attenuated vaccines against African swine fever: challenges and prospects

Parental strains

Genotypes

Attenuated strategies

LAV candidates

Protection

Production cells

References

NH/P68

I

Naturally attenuated

NH/P68

Homologous strain (L60, Arm07)

PBMs

[7]

OURT88/3

I

Naturally attenuated

OURT88/3

Homologous strain (OURT88/1, Ug65)

BMs

[8]

Lv17/WB/Rie1

II

Naturally attenuated

Lv17/WB/Rie1

Homologous strain

(Armo7)

PBMs

[10, 11]

BA71

I

DVAG (CD2v)

BA71ΔCD2v

Homologous and heterologous strain

(E75, Georgia 2007)

COS-1

[19]

HLJ/18

II

DVAG (MGF505-1R, MGF360-12L, MGF360-13L, MGF360-14L, MGF505-2R, MGF505-3R, and CD2v)

HLJ/18-7GD

Homologous strain

(ASFV HLJ/18)

PAMs

[23]

Georgia 2007

II

DVAG (I177L)

ASFV-G-ΔI177L

Homologous strain

(Georgia 2007)

PAMs

[21]

ASFV-G-ΔI177L

II

DVAG (I177L) and cell passage

ASFV-G-ΔI177L/ΔLVR

Homologous strain

(Georgia 2007)

PIPEC

[17]

ASFV-SY18

II

DVAG (CD2v and UK)

ASFV-SY18-ΔCD2v/UK

Homologous strain

(ASFV-SY18)

PAMs

[24]

ASFV-SY18

II

DVAG (I226R)

SY18ΔI226R

Homologous strain

(ASFV-SY18)

PAMs

[25]

Georgia 2010

II

DVAG (A137R)

ASFV-G-ΔA137R

Homologous strain

(Georgia 2010)

PAMs

[26]

  1. DVAG deletion of virulence-associated genes; PBMs porcine blood monocyte/macrophages; BMs pig bone marrow cells; COS-1 monkey kidney tissue-derived cells; PAMs primary porcine alveolar macrophages; PIPEC Plum Island porcine epithelial cells (PIPEC), a porcine fetal kidney cell line engineered to express the bovine αVβ6 integrin; LAV Live attenuated vaccine