Table.2 The seroconversion rate and GMT of SARS-CoV-2 neutralizing antibody in the three groups

Primary analysis

 GMT (95% CI)

98.4

(88.4–108.4)^a

134.4

(123.1–145.7)^b

145.5

(131.3–159.6)^b

93.5

(83.7–103.3)^a

122.0

(110.7–133.2)^b

129.8

(116.2–143.4)^b

Seroconversion (GMT ≥ 16)

 No, n (%)

0 (0.0)

0 (0.0)

0 (0.0)

14 (5.2)

23 (8.5)

28 (10.4)

 Yes, n (%)

256 (100.0)

247 (100.0)

241 (100.0)

256 (94.8)^a

247 (91.5)^ab

241 (89.6)^b

 Crude OR (95% CI)

–

–

–

1.0

0.6 (0.3–1.2)

0.5(0.2–0.9)

 Adjusted OR (95% CI)

–

–

–

1.0

0.6 (0.3–1.2)

0.5(0.3–1.0)

Secondary analysis

 GMT ≥ 32

  No, n (%)

34 (13.3)

9 (3.6)

10 (4.1)

48 (17.8)

32 (11.8)

38 (14.1)

  Yes, n (%)

222 (86.7)^a

238 (96.4)^b

231 (95.9)^b

222 (82.2)

238 (88.2)

231 (85.9)

  Crude OR (95% CI)

1.0

4.1 (1.9–8.6)

3.5 (1.7–7.3)

1.0

1.6 (1.0–2.6)

1.3 (0.8–2.1)

  Adjusted OR (95% CI)

1.0

4.1 (1.9–8.8)

3.6 (1.7–7.6)

1.0

1.7 (1.0–2.7)

1.4 (0.8–2.2)

 GMT ≥ 64

  No, n (%)

100 (39.1)

38 (15.4)

46 (19.1)

114 (42.2)

61 (22.6)

74 (27.5)

  Yes, n (%)

156 (60.9)^a

209 (84.6)^b

195 (80.9)^b

156 (57.8)^a

209 (77.4)^b

195 (72.5)^b

  Crude OR (95% CI)

1.0

3.5(2.3–5.4)

2.7(1.8–4.1)

1.0

2.5(1.7–3.6)

1.9 (1.3–2.8)

  Adjusted OR (95% CI)

1.0

3.5 (2.7–5.8)

2.7 (1.8–4.1)

1.0

2.5 (1.7–3.7)

1.9 (1.4–2.8)

 GMT ≥ 128

  No, n (%)

175 (68.4)

109 (44.1)

117 (48.5)

189 (70.0)

132 (48.9)

145 (53.9)

  Yes, n (%)

81 (31.6)^a

138 (55.9)^b

124 (51.5)^b

81 (30.0)^a

138 (51.1)^b

124 (46.1)^b

  Crude OR (95% CI)

1.0

2.7 (1.9–3.9)

2.3 (1.6–3.3)

1.0

2.44 (1.7–3.5)

2.0 (1.4–2.8)

  Adjusted OR (95% CI)

1.0

2.7 (1.9–3.9)

2.3 (1.6–3.4)

1.0

2.43 (1.7–3.5)

2.1 (1.4–3.0)

 GMT ≥ 256

  No, n (%)

233 (91.0)

210 (85.0)

199 (82.6)

247 (91.5)

233 (86.3)

227 (84.4)

  Yes, n (%)

23 (9.0)^a

37 (15.0)^b

42 (17.4)^b

23 (8.5)^a

37 (13.7) ^ab

42 (15.6)^b

  Crude OR (95% CI)

1.0

1.8 (1.0–3.1)

2.1 (1.2–3.7)

1.0

1.7 (1.0–3.0)

2.0 (1.2–3.4)

  Adjusted OR (95% CI)

1.0

1.8 (1.0–3.2)

2.3 (1.3–4.0)

1.0

1.8 (1.0–3.1)

2.1 (1.2–3.6)