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Table 2 Antimicrobial range of broad-spectrum defensins or defensin motifs

From: Defensins as a promising class of tick antimicrobial peptides: a scoping review

Defensin or defensin motif Microorganism References
Gram+ bacteria Gram− bacteria Fungi Viruses Protozoa
O. savignyi
Os, Os-C and Os(11–22)NH2
Bacillus subtilis; Staphylococcus aureus Escherichia coli; Pseudomonas aeruginosa Candida albicans [34, 50, 53]
D. silvarum
Ds-defensin
B. pumilus; S. aureus; Micrococcus luteus; Mycobacterium bovis Salmonella typhimurium; P. aeruginosa; E. coli C. albicans [38]
H. longicornis
longicin P4
S. aureus E. coli; P. aeruginosa; S. typhimurium Pichia pastoris Langat virus Babesia spp.
Toxoplasma gondii
[32, 37, 67]
H. longicornis
longicornsin
S. aureus E. coli; P. aeruginosa; Helicobacter pylori C. albicans [70]
H. longicornis
male-specific defensin
S. aureus; B. licheniformis E. coli; P. aeruginosa; Serratia rubidaea; Psychrobacter faecalis C. albicans [73]
H. longicornis
hemolymph defensin
M. luteus; B. cereus; S. aureus Langat virus [71, 72]
H. longicornis
DFS1
S. aureus; M. luteus; M. bovis E. coli; Borrelia burgdorferi C. albicans [74]
I. ricinus
DefMT3 and DefMT5
Listeria monocytogenes; L. fleischmannii; L. grayi; L. seeligeri; S. aureus P. aeruginosa Fusarium culmorum; F. graminearum Plasmodium falciparum [82, 83]
I. ricinus
DefMT6
L. monocytogenes; L. fleischmannii; L. grayi; L. seeligeri; S. aureus; S. epidermidis P. aeruginosa; E. coli F. culmorum; F. graminearum [82, 83]
I. holocyclus
holosin 2 and holosin3
S. aureus; S. epidermidis; L.grayi E. coli; P. aeruginosa F. graminearum; C. albicans [41]