Fig. 8

Therapeutic efficacy of phage vB_BpP_HN01 against B. pseudomallei infection in C. elegans. Survival curves of the blank control (open circle), C. elegans infected by B. pseudomallei HNBP001 (open triangle), infected C. elegans treated with phage vB_BpP_HN01 (open diamond), and the C. elegans treated with phage alone (open square) were plotted using the Kaplan–Meier method, in which results represent the average of triplicates. Through the log-rank test, a statistically significant difference (P < 0.05) was demonstrated in the treatment groups (A). Through the fluorescent probe, the presence of B. pseudomallei in the infected C. elegans (B) is seen, particularly in the intestine, whilst this is considerably diminished following phage treatment (C). Bp: B. pseudomallei