A novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics

Wang, Yanshuang; Li, Xuemiao; Dance, David A. B.; Xia, Han; Chen, Chen; Luo, Nini; Li, Anyang; Li, Yanmei; Zhu, Qiao; Sun, Qinghui; Wu, Xingyong; Zeng, Yingfei; Chen, Lin; Tian, Shen; Xia, Qianfeng

doi:10.1186/s40249-022-01012-9

Infectious Diseases of Poverty

Table 1 The B. pseudomallei clinical isolates and other bacteria used in the lytic spectrum test

From: A novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics

Strains/Isolates/Species	Age, years	Sex	City of residence	Symptom	Clinical specimen	Treatment outcome	Susceptibility to lysis by vB_BpP_HN01	ST types
BpNo01	57	Man	Dongfang	Pulmonary infection and sepsis	Blood	Recovered	+	46
BpNo02	58	Man	Dongfang	Pulmonary infection	Bronchoalveolar lavage fluid	Recovered	+	46
BpNo03	31	Man	Ledong	Sepsis	Joint fluid	Recovered	+	46
BpNo04	39	Man	Qiongzhong	Sepsis	Blood	Recovered	+	1105
BpNo05	45	Man	Ledong	Sepsis	Blood	Recovered	+	46
BpNo06	60	Man	Danzhou	Sepsis	Sputum	Recovered	+	New^c
BpNo07	51	Man	Haikou	Pulmonary infection and septic arthritis	Blood/Sputum	Recovered	+	46
BpNo08	67	Man	Sanya	Sepsis	Urine	Recovered	+	30
BpNo09	57	Man	Haikou	Sepsis	Blood	Recovered	+	New^c
BpNo10	66	Man	Dingan	sepsis	Blood	Recovered	+	50
BpNo11	30	Woman	Changjiang	Pulmonary infection and sepsis	Blood	Recovered	+	46
BpNo12	80	Man	Haikou	Pulmonary infection and sepsis	Blood	Recovered	–	164
BpNo13	77	Man	Dongfang	Pulmonary infection and septic arthritis	Blood	Died	+	46
BpNo14	52	Man	Dongfang	Pulmonary infection	Bronchoalveolar lavage fluid	Recovered	+	New^c
BpNo15	40	Man	Wanning	Sepsis	Blood	Recovered	+	46
BpNo16	54	Man	Danzhou	Pulmonary infection and sepsis	Blood	Recovered	+	46
BpNo17	49	Man	Sanya	Pulmonary infection and sepsis	Bronchoalveolar lavage fluid	Recovered	+	46
BpNo18	36	Man	Changjiang	Pulmonary infection and sepsis	Blood	Recovered	+	70
BpNo19	59	Man	Haikou	Sepsis	Blood	Recovered	+	New^c
BpNo20	55	Woman	Wenchang	Pulmonary infection and sepsis	Joint fluid	Recovered	+	1545
BpNo21	63	Man	Dongfang	Pulmonary infection	Bronchoalveolar lavage fluid	Recovered	+	46
BpNo22	48	Man	Changjiang	Sepsis	Blood	Recovered	+	46
BpNo23	48	Man	Wenchang	Pulmonary infection and sepsis	Bronchoalveolar lavage fluid	Recovered	+	58
BpNo24	64	Man	Sanya	Sepsis	Blood	Recovered	+	46
BpNo25	66	Man	Dongfang	Pulmonary infection and sepsis	Bronchoalveolar lavage fluid	Recovered	+	164
BcNo01	57	Man	Wanning	Chronic obstructive pulmonary disease	Bronchoalveolar lavage fluid	Recovered	–
BcNo02	54	Woman	Haikou^a	Pulmonary infection	Sputum	Recovered	–
ATCC29212^b							–
ATCC25923^b							–
ATCC27853^b							–
ATCC25922^b							–

^aThis patient is a traveler from Anhui Province; ^bThese bacteria are reference strains of Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa; ^cThey were assigned new subtypes, since no results were outputted from pubMLST after submitting the sequencing results of 7 house-keeping genes (ace, gltB, gmhD, lepA, lipA, nark, ndH) in Bpn006, Bpn009, Bpn014, and Bpn019

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ISSN: 2049-9957

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