Skip to main content
Fig. 1 | Infectious Diseases of Poverty

Fig. 1

From: A unified global genotyping framework of dengue virus serotype-1 for a stratified coordinated surveillance strategy of dengue epidemics

Fig. 1

Global genotyping framework of DENV-1 established based on its population structure, phylogeny, and epidemiology. a, e The dots at the tip of each strains are marked with different colour representing 41 subgenotypes identified. a The unified global framework of DENV-1 subgenotypes is labeled in the phylogenetic tree of the complete E gene sequences of 5003 DENV-1 strains worldwide. Due to inadequate strains recorded, only 5 and 3 strains of genotype II and III were defined in a single subgenotype (2A and 3A) and clade (2A1 and 3A1), respectively. b The defined genotyping framework of DENV-1 represents an increasing intra-taxon divergence of the mean pairwise distances (MPDs). c The correlation between the substitution rate and time to the most common ancestor (tMRCA) was assessed using a linear regression model, after adjusting the inclusive number of strains, MPDs, and Simpson Index. d The dynamics description of the estimated viral population size of DENV-1 with the cumulative percentages of inclusive strains, clades, subgenotypes of DENV-1, and the involving epidemic countries or areas. e The temporal phylogeny of DENV-1 using 910 strains selected among the total 5003 ones worldwide which cover the full spatiotemporal ranges and represent all subgenotypes and clades in genotype I, IV, and V of DENV-1. The features of the selected 910 E complete sequences are presented in Additional file 3: Appendix-Data S-C1. The linear regression of root-to-tip genetic divergences versus strain sampling dates is displayed in Additional file 1: Fig. S C1. The gray vertical dotted lines show three sharp increases in the estimated viral population size of DENV-1 during the three periods of 1976–1977, 1996–1998, and 2005–2006

Back to article page