Table 2 The diagnostic performance of occurrence of 4 key clinical presentations for human African trypanosomiasis (HAT) diagnosis
Number of signs or symptoms present | % Sensitivity (n/N, 95% CI) | % Specificity (n/N, 95% CI) | % PPV (n/N, 95% CI) | % NPV (n/N, 95% CI) | % Accuracy (n/N, 95% CI) |
|---|---|---|---|---|---|
≥ 1/4 | 97.9 (47/48, 88.9–99.9) | 75.6 (1737/2297, 73.8–77.4) | 7.7 (47/607, 5.7–10.2) | 99.9 (1737/1738, 99.7–100) | 76.1 (1784/2345, 74.3–77.8) |
≥ 2/4 | 87.5 (42/48, 74.8–95.3) | 97.2 (2232/2297, 96.4–97.8) | 39.3 (42/107, 30.1–49.2) | 99.7 (2232/2238, 99.4–99.9) | 97.0 (2274/2345, 96.2–97.6) |
≥ 3/4 | 56.3 (27/48, 41.2–70.5) | 99.7 (2289/2297, 99.3–99.9) | 77.1 (27/35, 59.9–89.6) | 99.1 (2298/2310, 98.6–99.4) | 98.8 (2316/2345, 98.2–99.2) |
4/4 | 18.8 (9/48, 9.0–32.6) | 100 (2297/2297, 99.8–100) | 100 (9/9, 66.4–100) | 98.3 (2297/2336, 97.7–98.8) | 98.3 (2306/2345, 97.7–98.8) |