Table 2 Performance of PURE-LAMP, RDT and microscopy against nested PCR as reference
Sensitivity, n/d % (95% CI) | Specificity, n/d % (95% CI) | PPV, n/d % (95% CI) | NPV, n/d % (95% CI) | Kappa | |
|---|---|---|---|---|---|
PURE-LAMP Pan | 89/89 100 (95.9–100) | 976/985 99.1 (98.3–99.6) | 89/98 90.8 (83.3–95.7) | 976/976 100 (99.6–100) | 0.95 |
PURE-LAMP Pf | 88/89 98.9 (93.9–100) | 977/985 99.2 (98.4–99.6) | 88/96 91.7 (84.2–96.3) | 977/978 99.9 (99.4–100) | 0.95 |
RDT Pan | 54/89 60.7 (49.7–70.9) | 983/985 99.8 (99.3–100) | 54/56 96.4 (87.7–99.6) | 983/1018 96.6 (95.2–97.6) | 0.73 |
RDT Pf | 76/89 85.4 (76.3–92.0) | 980/985 99.5 (98.8–99.8) | 76/81 93.8 (86.2–98.0) | 980/993 98.7 (97.8–99.3) | 0.88 |
Microscopy | 44/89 49.4 (38.7–60.2) | 978/985 99.3 (98.5–99.7) | 44/51 86.3 (73.7–94.3) | 978/1023 95.6 (94.1–96.8) | 0.60 |