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Table 4 Results for the overall and subgroup analysis according to type of study and treatment

From: Community-based interventions for the prevention and control of helmintic neglected tropical diseases

Outcomes Estimates (95% CI)  
  Combined RCTs Pre-post studies Preventive Therapeutic
STH Prevalence (RR) 0.47 [0.41, 0.54] 0.47 [0.41, 0.55] 0.51 [0.40, 0.65] 0.43 [0.31, 0.59] 0.52 [0.44, 0.61]
45 datasets from 12 studies 40 datasets from 9 studies 5 datasets from 3 studies 22 datasets from 7 studies 23 datasets from 5 studies
Hookworm 0.40 [0.31, 0.52] 0.41 [0.32, 0.54] 0.39 [0.23, 0.65] 0.26 [0.14, 0.45] 0.60 [0.46, 0.78]
15 datasets, 10 studies 13 datasets from 8 studies 2 datasets from 2 studies 8 datasets from 6 studies 7 datasets from 4 studies
Ascariasis 0.32 [0.20, 0.51] 0.30 [0.18, 0.49] 0.61 [0.41, 0.90] 0.62 [0.38, 1.01] 0.18 [0.08, 0.40]
15 datasets, 9 studies 14 datasets from 8 studies 1 dataset from 1 study 7 datasets from 4 studies 8 datasets from 5 studies
Trichuriasis 0.66 [0.55, 0.80] 0.65 [0.53, 0.79] 0.97 [0.68, 1.37] 0.57 [0.22, 1.46] 0.76 [0.66, 0.88]
14 datasets, 8 studies 13 datasets from 7 studies 1 dataset from 1 study 6 datasets from 3 studies 8 datasets from 5 studies
Schistosomiasis Prevalence (RR) 0.41 [0.34, 0.50] 0.42 [0.33, 0.54] 0.37 [0.25, 0.55] 0.39 [0.27, 0.55] 0.41 [0.30, 0.55]
25 datasets, 13 studies 16 datasets from 6 studies 9 datasets from 7 studies 11 datasets from 7studies 14 datasets from 6 studies
Schistosoma Haematobium 0.41 [0.30, 0.57] 0.43 [0.29, 0.64] 0.33 [0.17, 0.65] 0.59 [0.35, 1.02] 0.31 [0.18, 0.52]
10 datasets, 8 studies 6 datasets from 4 studies 4 datasets from 4 studies 3 datasets from 3 studies 7 datasets from 5 studies
Schistosoma Japonicum 0.24 [0.07, 0.80] 0.24 [0.07, 0.80] No studies 0.11 [0.05, 0.26] 0.30 [0.07, 1.31]
4 datasets, 2 studies 4 datasets from 2 studies 1 dataset from 1 study 3 datasets from 1 study
Schistosoma Mansoni 0.48 [0.36, 0.64] 0.55 [0.38, 0.81] 0.39 [0.25, 0.62] 0.37 [0.24, 0.58] 0.67 [0.45, 1.01]
11 datasets, 7 studies 6 datasets from 2 studies 5 datasets from 5 studies 7 datasets from 5 studies 4 datasets from 2 studies
STH intensity (SMD) −3.16 [−4.28, −2.04] −5.29 [−9.22, −1.36] −0.22 [−0.26, −0.17] −0.22 [−0.26, −0.17] −5.29 [−9.22, −1.36]
5 datasets, 3 studies 3 datasets from 1 study 2 datasets from 2 studies 2 datasets from 2 studies 3 datasets from 1 study
Hookworm −2.22 [−3.27, −1.17] −6.79 [−7.44, −6.14] −0.22 [−0.26, −0.17] −0.22 [−0.26, −0.17] −6.79 [−7.44, −6.14]
3 datasets, 03 studies 1 dataset from 1 study 2 datasets from 2 studies 2 datasets from 2 studies 1 dataset from 1 study
Ascariasis −7.25 [−7.93, −6.56] −7.25 [−7.93, −6.56] No studies No studies −7.25 [−7.93, −6.56]
1 dataset, 1 study 1 dataset from 1 study 1 dataset from 1 study
Trichuriasis −1.87 [−2.16, −1.57] −1.87 [−2.16, −1.57] No Studies No studies −1.87 [−2.16, −1.57]
1 dataset, 01 study 1 dataset from 1 study 1 dataset from 1 study
Mean hemoglobin (SMD) 0.34 [0.20, 0.47] 0.43 [0.15, 0.71] 0.22 [0.13, 0.31] 0.19 [0.12, 0.26] 1.28 [−0.53, 3.08]
14 datasets, 12 studies 9 datasets from 7 studies 5 datasets from 5 studies 12 datasets from 10 studies 2 datasets from 2 studies
Anemia 0.90 [0.85, 0.96] 0.92 [0.85, 1.00] 0.87 [0.78, 0.97] 0.90 [0.85, 0.96] 0.85 [0.69, 1.06]
9 datasets, 7 studies 5 datasets from 3 studies 4 datasets from 4 studies 8 datasets from 6 studies 1 dataset from 1 study
Serum ferritin (SMD) 2.30 [−1.13, 5.73] 0.06 [−0.07, 0.18] 0.10 [−0.16, 0.37] 0.09 [−0.12, 0.29] 0.07 [−0.07, 0.20]
4 datasets, 4 studies 2 dataset from 2 studies 2 datasets from 2 studies 3 datasets from 3 studies 1 dataset from 1 study
Height 0.01 [−0.10, 0.12] −0.04 [−0.16, 0.08] 0.23 [−0.02, 0.49] 0.08 [−0.12, 0.28] −0.02 [−0.15, 0.11]
4 datasets, 4 studies 3 datasets from 3 studies 1 dataset from 1 study 2 datasets from 2 studies 2 datasets from 2 studies
Weight −0.13 [−0.42, 0.16] −0.28 [−0.66, 0.11] 0.22 [−0.03, 0.47] −0.01 [−0.48, 0.46] −0.35 [−1.13, 0.42]
4 datasets, 4 studies 3 datasets from 3 studies 1 dataset from 1 study 2 datasets from 2 studies 2 data sets from 2 studies
Birth outcomes      
Birth weight −9.52 [−13.86, −5.19] −9.52 [−13.86, −5.19] No studies −9.52 [−13.86, −5.19] No study
6 datasets, 3 studies 6 datasets from 3 studies 6 datasets from 3 studies
LBW 0.96 [0.78, 1.18] 0.96 [0.78, 1.18] No studies 0.96 [0.78, 1.18] No studies
4 datasets, 2 studies 4 datasets from 2 studies 4 datasets from 2 studies
VLBW 0.48 [0.19, 1.19] 0.48 [0.19, 1.19] No studies 0.48 [0.19, 1.19] No studies
4 datasets, 2 studies 4 datasets, 2 studies 4 datasets, 2 studies
Stillbirths 1.54 [0.93, 2.58] 1.54 [0.93, 2.58] No studies 1.54 [0.93, 2.58] No studies
3 datasets, 1 study 3 datasets from 1 study 3 datasets from 1 study
  1. *estimates in bold are statistically significant.