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Table 4 Sensitivity of P. falciparum to pyronaridine and artesunate

From: Surveillance of antimalarial drug resistance in China in the 1980s–1990s

Drug Province In vitro test In vivo test
Year No. of cases examined Inhibition concentration(pmoll)* Year No. of cases examined Defervescence time(h) Parasite clearance time(h)
Pyronaridine Hainan 1986 20 0.08 1986 42 32.9 ± 12.4 43.3 ± 23.3
1997 37 1.36 1996 13 40.2 ± 15.7 62.5 ± 28.7
Yunnan 1988 25 0.14     
Artesunate Hainan 1986 18 0.028     
2002 32 0.135     
Yunnan 1988 24 0.038     
2002 22 0.054     
  1. *The mean drug concentration for complete inhibition of schizont maturation.