Table 1 Structures of the confirmed hits and their inhibition of SmTGR and cidal activities against worms

WNN0724-H007

0.424 ± 0.106

98.57 ± 1.36

50

–^e

WNN0809-E009

3.848 ± 0.311

99.60 ± 0.26

n.a. ^d

–

WNN0256-E003

4.476 ± 0.905

98.99 ± 0.45

n.a.

–

WNN0434-C002

1.448 ± 0.141

98.48 ± 1.48

25

–

WNN1041-F010

3.181 ± 0.636

97.34 ± 3.30

n.a.

–

WNN0328-C003

5.362 ± 0.453

99.41 ± 0.09

n.a.

–

WNN0625-C003

2.981 ± 0.438

98.69 ± 1.42

n.a.

–

WNN1087-E003

13.21 ± 1.775

95.92 ± 0.12

n.a.

–

WNN0397-C010

0.862 ± 0.120

95.55 ± 2.02

3.125

n.a.

WNN0042-E008

1.614 ± 0.375

94.31 ± 1.53

n.a.

–

WNN0929-D011

0.957 ± 0.232

97.08 ± 1.53

50

–

WNN0929-D007

3.576 ± 0.417

97.86 ± 0.21

n.a.

–

WNN0464-C005

1.038 ± 0.198

98.23 ± 2.04

25

–

WNN0464-F002

1.667 ± 0.325

97.51 ± 0.75

12.5

–

WNN0474-E006

2.410 ± 0.438

97.22 ± 0.81

n.a.

–

WNN0366-E010

2.605 ± 0.544

73.26 ± 1.61

6.25

–

WNN0544-A007

5.595 ± 0.431

98.62 ± 1.50

n.a.

–

WNN0912-G011

6.633 ± 1.209

96.87 ± 2.64

n.a.

–

WNN0197-D004

3.152 ± 0.509

96.75 ± 0.68

3.125

5

WNN0429-D003

7.243 ± 0.530

98.57 ± 0.63

50

–

WNN0446-H009

6.290 ± 0.177

85.95 ± 2.33

50

–

WNN0194-D004

3.238 ± 0.481

98.65 ± 1.37

50

–

WNN0373-D002

3.352 ± 0.481

82.32 ± 1.51

6.25

–

WNN0464-C004

3.029 ± 0.410

95.73 ± 0.86

6.25

–

WNN0609-E009

7.662 ± 0.870

82.93 ± 1.20

3.125

n.a.

WNN0192-H003

4.900 ± 0.955

94.49 ± 1.31

n.a.

–

WNN0029-D010

7.919 ± 0.488

97.19 ± 0.74

n.a.

–

WNN0029-D009

11.89 ± 0.474

92.95 ± 0.40

n.a.

–

WNN0224-E010

11.62 ± 0.346

99.21 ± 0.21

50

–

WNN0113-H010

12.78 ± 0.841

92.49 ± 1.05

n.a.

–

WNN0113-H004

9.286 ± 0.622

77.86 ± 2.78

n.a.

–

WNN0113-H003

13.08 ± 0.643

74.21 ± 1.41

n.a.

–

WNN0009-G004

2.595 ± 0.233

98.03 ± 1.12

12.5

–

WNN0341-B004

6.076 ± 0.849

98.97 ± 0.87

n.a.

–

WNN0287-H004

3.257 ± 0.792

91.03 ± 0.45

25

–

WNN0189-G005

15.73 ± 1.351

77.53 ± 0.99

n.a.

–

WNN0621-C011

8.643 ± 0.912

78.09 ± 2.19

n.a.

–

WNN0367-F009

0.612 ± 0.057

98.35 ± 1.32

25

–

WNN0809-C005

17.63 ± 0.863

99.20 ± 0.62

6.25

–

WNN0009-H010

28.61 ± 1.131

96.77 ± 0.49

50

–

WNN0409-G007

3.548 ± 0.064

98.56 ± 1.56

n.a.

–

WNN0197-G002

5.438 ± 0.552

98.09 ± 1.56

3.125

10

WNN0009-A002

14.47 ± 0.990

82.47 ± 1.70

50

–

WNN0925-B011

1.352 ± 0.123

94.87 ± 0.19

n.a.

–

WNN0029-C005

0.003 ± 0.001

97.40 ± 1.50

12.5

–

WNN0726-A010

2.614 ± 0.262

98.70 ± 1.63

50

–

WNN0463-G011

7.171 ± 0.226

95.20 ± 2.54

n.a.

–

WNN0335-G006

13.05 ± 0.028

94.88 ± 1.48

12.5

–

WNN0961-C005

2.643 ± 0.276

95.77 ± 1.08

n.a.

–

WNN0374-G010

4.995 ± 0.290

72.99 ± 3.01

50

–

WNN0304-A007

2.886 ± 0.976

97.56 ± 2.98

50

–

WNN0826-B004

2.214 ± 0.799

93.88 ± 0.17

25

–

WNN0893-H007

5.019 ± 0.212

95.89 ± 1.26

n.a.

–

WNN0196-F005

6.719 ± 0.233

73.87 ± 0.93

50

–

WNN0493-F008

6.305 ± 0.523

78.85 ± 2.35

3.125

10

WNN0395-A008

7.871 ± 0.728

98.51 ± 1.39

n.a.

–

WNN1018-E008

11.98 ± 0.898

95.62 ± 2.29

n.a.

–

WNN1177-H006

0.831 ± 0.113

98.02 ± 1.44

n.a.

–

WNN0263-A002

16.14 ± 0.884

98.88 ± 0.79

6.25

–

WNN0035-G011

18.23 ± 1.591

96.60 ± 0.67

12.5

–

WNN1177-F009

1.576 ± 0.304

97.00 ± 1.41

n.a.

–

WNN0572-G004

2.119 ± 0.502

98.46 ± 1.61

50

–

WNN0493-H007

3.057 ± 0.495

98.71 ± 0.83

n.a.

–

WNN0826-A003

2.862 ± 0.163

97.36 ± 1.75

50

–

WNN0307-H007

7.348 ± 0.219

98.44 ± 0.80

50

–

WNN0045-G003

9.057 ± 1.117

98.78 ± 0.76

12.5

–

WNN0004-A011

0.004 ± 0.001

95.89 ± 4.91

50

–

WNN0058-C010

0.562 ± 0.071

77.47 ± 1.08

50

–

WNN0433-C010

1.938 ± 0.431

85.21 ± 2.02

n.a.

–

WNN0151-C005

3.286 ± 0.240

97.06 ± 1.17

n.a.

–

WNN0646-C002

14.78 ± 1.619

90.0 ± 1.379

12.5

–

WNN0040-H011

46.90 ± 5.544

96.74 ± 0.72

n.a.

–

WNN0341-C002

4.395 ± 0.403

90.48 ± 1.06

n.a.

–

WNN0826-A007

0.205 ± 0.148

98.36 ± 1.29

n.a.

–