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Table 6 Therapeutic outcomes based on age group in children treated with artemether-lumefantrine

From: Therapeutic efficacy and effects of artesunate-amodiaquine and artemether-lumefantrine on malaria-associated anaemia in Nigerian children aged two years and under

Parameter ≤2 years (n = 130) <5 years (n = 418)
<1 year (n = 46) ≥1 year (n = 84) P value ≤2 years (n = 130) ≥2– < 5 years (n = 288) P value
Haematocrit (%)
 Mean 28.9 28.9 0.96 28.9 29.9 0.05
 95 % CI 27.4–30.3 28–29.8 28.1–29.7 29.3–30.5
 No <30 % 19 40 0.61 59 129 0.99
Parasitaemia (μL−1)
 Geometric mean 11,981 17,207 0.16 15,138 23,001 0.003
 Range 1,000–304,500 1108–288,461   1,000–305,500 1,030–2,124,000  
 No. >100,000 μL−1 1 6 0.43 7 50 0.002
 No. >250,000 μL−1 1 1 1.0 2 8 0.73
 ACPR on day 28 (%) 45/46 (98) 77/81 (95) 0.65 122/127 (96) 265/279 (95) 0.82
 Parasite prevalence on day 1 18 (39) 60 0.04 68 (52) 154 (53) 0.91
PRRD1
 Geometric mean 9.1 × 102 4.0 × 102 0.31 5.4 × 102 5.6 × 102 1.0
 Range 1.7 × 100–8.7 × 104 4.1 × 10−1–2.9 × 105   4.1 × 10−1–2.9 × 105 9.5 × 10−1–2.1 × 106  
PRRD2
 Geometric mean 1.1 × 104 1.2 × 104 0.51 1.1 × 104 1.8 × 104 0.004
 Range 3.2 × 101–3.0 × 105 2.6 × 101–2.9 × 105   2.6 × 101–3.0 × 105 1.7 × 101–2.1 × 106  
 Parasite positivity rate on day 3 0 1 - 1 1 0.53
Fever clearance time (day)
 Mean 1.2 1.3 0.64 1.3 1.2 0.4
 95 % CI 1.1–1.4 1–1.6 1.1–1.5 1.1–1.3
Parasite clearance time (day)
 Mean 1.4 1.7 0.01 1.6 1.6 0.92
 95 % CI 1.3–1.6 1.6–1.8 1.5–1.7 1.5–1.7
Anaemia recovery time (day)
 Mean 15.3 12.5 0.29 13.2 11 0.12
 95 % CI 10.6–20.1 9.7–15.3 10.9–15.6 9.4–12.6
  1. ACPR adequate clinical and parasitological response, PRR D1 parasite reduction ratio 1 day after treatment started, PRR D2 parasite reduction ratio 2 days after treatment started