|
Parameter
|
≤2 years (n = 130)
|
<5 years (n = 418)
|
|---|
|
<1 year (n = 46)
|
≥1 year (n = 84)
|
P value
|
≤2 years (n = 130)
|
≥2– < 5 years (n = 288)
|
P value
|
|---|
|
Haematocrit (%)
|
|
Mean
|
28.9
|
28.9
|
0.96
|
28.9
|
29.9
|
0.05
|
|
95 % CI
|
27.4–30.3
|
28–29.8
|
28.1–29.7
|
29.3–30.5
|
|
No <30 %
|
19
|
40
|
0.61
|
59
|
129
|
0.99
|
|
Parasitaemia (μL−1)
|
|
Geometric mean
|
11,981
|
17,207
|
0.16
|
15,138
|
23,001
|
0.003
|
|
Range
|
1,000–304,500
|
1108–288,461
| |
1,000–305,500
|
1,030–2,124,000
| |
|
No. >100,000 μL−1
|
1
|
6
|
0.43
|
7
|
50
|
0.002
|
|
No. >250,000 μL−1
|
1
|
1
|
1.0
|
2
|
8
|
0.73
|
|
ACPR on day 28 (%)
|
45/46 (98)
|
77/81 (95)
|
0.65
|
122/127 (96)
|
265/279 (95)
|
0.82
|
|
Parasite prevalence on day 1
|
18 (39)
|
60
|
0.04
|
68 (52)
|
154 (53)
|
0.91
|
|
PRRD1
|
|
Geometric mean
|
9.1 × 102
|
4.0 × 102
|
0.31
|
5.4 × 102
|
5.6 × 102
|
1.0
|
|
Range
|
1.7 × 100–8.7 × 104
|
4.1 × 10−1–2.9 × 105
| |
4.1 × 10−1–2.9 × 105
|
9.5 × 10−1–2.1 × 106
| |
|
PRRD2
|
|
Geometric mean
|
1.1 × 104
|
1.2 × 104
|
0.51
|
1.1 × 104
|
1.8 × 104
|
0.004
|
|
Range
|
3.2 × 101–3.0 × 105
|
2.6 × 101–2.9 × 105
| |
2.6 × 101–3.0 × 105
|
1.7 × 101–2.1 × 106
| |
|
Parasite positivity rate on day 3
|
0
|
1
|
-
|
1
|
1
|
0.53
|
|
Fever clearance time (day)
|
|
Mean
|
1.2
|
1.3
|
0.64
|
1.3
|
1.2
|
0.4
|
|
95 % CI
|
1.1–1.4
|
1–1.6
|
1.1–1.5
|
1.1–1.3
|
|
Parasite clearance time (day)
|
|
Mean
|
1.4
|
1.7
|
0.01
|
1.6
|
1.6
|
0.92
|
|
95 % CI
|
1.3–1.6
|
1.6–1.8
|
1.5–1.7
|
1.5–1.7
|
|
Anaemia recovery time (day)
|
|
Mean
|
15.3
|
12.5
|
0.29
|
13.2
|
11
|
0.12
|
|
95 % CI
|
10.6–20.1
|
9.7–15.3
|
10.9–15.6
|
9.4–12.6
|
-
ACPR adequate clinical and parasitological response, PRR
D1
parasite reduction ratio 1 day after treatment started, PRR
D2
parasite reduction ratio 2 days after treatment started
