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Table 5 Diagnostic characteristics of the various tests to diagnose S. mekongi infection using a combined referencea

From: Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia

Method ELISAb Kato-Katz POC-CCA CAA CAA CAA
Target Antibodies Parasite eggs Circulating antigens
Sample Serum Faeces Urine Urine Serum Serum + urine
  (%) (%) (%) (%) (%) (%)
Sensitivity 52.9 13.8 24.1 83.9 70.1 93.7
Specificity 81.3 100 81.8 100 100 100
PPV* 70.8 100 53.2 100 100 100
NPV** 66.8 57.5 55.7 87.9 79.6 94.9
  1. *Positive predictive value; **Negative predictive value; aInfection-positive by either egg- or CAA-positivity (serum and urine combined, assuming 100% specificity of the CAA result). bFor the ELISA, either AWE and/or SEA positive was considered positive