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Table 3 Genetic risk factors for CCA

From: Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region: a systematic review and meta-analysis

Gene Title Function CCA Risk Source
OGG1 8-oxoguanine DNA glycosylase 1 DNA repair not significanta Zeng 2013 [30]
OGG1 8-oxoguanine DNA glycosylase 1 DNA repair not significanta Songserm 2014 [26]
PARP-1 poly-ADP-ribose polymerase 1 DNA repair not significanta Zeng 2013 [30]
XRCC1 X-ray repair cross-compelementing protein 1 DNA repair not significanta Songserm 2014 [26]
XRCC1 X-ray repair cross-complementing protein 1 DNA repair not significanta Zeng 2013 [30]
IL-6R interleukin 6 receptor inflammation increased C allele frequency decreased risk Prayong 2014 [34]
CHST4 sulfotransferase metabolism upregulated in Thai CCA Jinawath 2006 [31]
CYP1A2 cytochrome P450 oxidase metabolism CYP1A2*1A/*1A decreased risk in mena Prawan 2005 [29]
CYP2A6 cytochrome P450 oxidase metabolism increased expression in CCA Yongvanit 2012 [32]
CYP2E1 cytochrome P450 oxidase metabolism decreased expression in CCA Yongvanit 2012 [32]
GST01 glutathione-s-transferase metabolism GST01*D140 increased risk Marahatta 2006 [55]
GST02 glutathione-s-transferase metabolism not significant Marahatta 2006 [55]
GSTM1 glutathione-S-transferase metabolism not significanta Honjo 2005 [23]
GSTT1 glutathione-S-transferase metabolism not significanta Honjo 2005 [23]
MTHFR methylenetetrahydrofolate reductase metabolism A1298C CC variant increased riska Songserm 2011 [27]
MTHFR methylenetetrahydrofolate reductase metabolism A1298C CC variant increased riska Songserm 2012 [24]
NAT1 catalyze N and O acetylation metabolism NAT1*11 decreased risk Prawan 2005 [29]
NAT2 catalyze N and O acetylation metabolism NAT2*13, *6B, and *7A decreased risk Prawan 2005 [29]
SULT1C1 sulfotransferase metabolism upregulated in Thai CCA Jinawath 2006 [31]
UGT1A10 UDP-glucuronosyltransferase metabolism upregulated in Thai CCA Jinawath 2006 [31]
UGT2B11 UDP-glucuronosyltransferase metabolism upregulated in Thai CCA Jinawath 2006 [31]
  1. aGene has significant interaction with or modification of other risk factors, see Table 4