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Table 3 Predictors of parasite reduction ratio ≥ 10 000 two days after initiation of artemisinin-based combination therapies in acutely malarious young children

From: Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Variable Total No. No. with PRRD2 ≥ 10 000 OR (95% CI) P value aOR (95% CI) P value
Gender
 Female 424 202 1    
 Male 495 240 1.0 (0.8–1.3) 0.85
Age (month)
  ≤ 30 284 121 1   1  
  > 30 629 320 1.4 (1.1–1.9) 0.02 1.4 (1.0–1.9) 0.03
Duration of illness (days)
  ≤ 2 269 163 1    
  > 2 334 194 1.3 (0.8–2.0) 0.59
Haematocrit at presentation (%)
  < 31 465 201 1   1  
  ≥ 31 434 236 1.6 (1.2–2.0) 0.001 1.5 (1.1–1.9) 0.01
Haematocrit on day 1 (%)
  < 30 407 123 1    
  ≥ 30 483 226 0.8 (0.6–1.0) 0.11
History of fever before treatment
 Absent 170 75 1    
 Present 749 367 1.2 (0.9–1.7) 0.29
Temperature at presentation (°C)
  ≤ 37.4 349 125 1   1  
  > 37.4 570 317 2.2 (1.7–3.0) < 0.0001 2.0 (1.5–2.7) < 0.0001
Fever on day 1*
 Absent 797 394 1    
 Present 103 47 0.9 (0.6–1.3) 0.53
Enrolment Parasitaemia
  ≤ 105 823 380 1   1  
  > 105 96 62 2.1 (1.4–3.3) < 0.0001 1.9 (1.2–3) 0.01
PRRD1
  ≤ 103 501 205 1   1  
  > 103 418 237 1.9 (1.5–2.5) < 0.0001 2.1 (1.6–2.7) < 0.0001
Gametocytaemia
 Present 48 10 1   1  
 Absent 871 432 3.7 (1.8–7.6) < 0.0001 2.4 (1.1–5.0) 0.02
Drug treatment
 AL 303 141 1    
 AA 295 144 1.1 (0.8–1.5) 0.64
 DHP 321 157 1.1 (0.8–1.5) 0.61
  1. PRRD1 Parasite reduction ratio 1 day post-treatment initiation, PRRD2 Parasite reduction ratio 2 days post-treatment initiation, AL Artemether-lumefantrine, AA Artesunate-amodiaquine, DHP Ddihydroartemisinin-piperaquine, CI Confidence interval, OR Odd ratio, aOR Adjusted odd ratio
  2. *Fever 1 day post-treatment initiation