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Table 4 Baseline characteristics and parasitological responses in dihydroartemisinin-piperaquine-treated children who participated in evaluation of the comparison of estimates of parasite clearance time derived from linear regression equation and microscopy-determined parasite clearance time

From: Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Variables Initial phase (n = 166) Later phase (n = 155) All (n = 321) P value
Male: Female 90:76 93:62 183:138 0.35
Age (month)
 Mean (95% CI) 37.6 (34.9–40.2) 39.5 (36.9–42) 38.1 (36.4–39.7) 0.31
 No. ≤ 12 months (%) 16 (9.6) 13 (8.4) 29 (9) 0.84
Duration of illness (day)
 Mean (95% CI) 3.8 (3.2–4.4) 4.1 (3.4–4.7) 3.8 (3.4–4.2) 0.53
Weight (kg)
 Mean (95% CI) 12.8 (12.2–13.5) 13.1 (12.5–13.7) 12.9 (12.4–13.3) 0.56
Temperature (°C)
 Mean (95% CI) 37.8 (37.6–38) 37.8 (37.5–38) 37.8 (37.7–37.9) 0.8
No. with
  ≥ 37.5 °C (%) 94 (56.6) 99 (63.9) 193 (60.1) 0.23
  ≥ 40 °C (%) 15 (9) 13 (8.4) 28 (8.7) 0.99
Haematocrit (%)
 Mean (95% CI) 30.6 (29.7–31.5) 31.3 (30.6–32) 30.8 (30.3–31.4) 0.21
 No with anaemia (%) 59 (35.5) 45 (29) 104 (32.4) 0.34
  Mild (%) 48 (28.9) 43 (27.7) 91 (28.3) 0.65
  Moderate (%) 11 (6.6) 2 (1.3) 13 (4) 0.02
  Severe (%) 0 (0) 0 (0) 0 (0)
Parasitaemia (/μl)
 Geometric mean (Range) 16 319 (2000–200 000) 14 057 (2003–198 000) 15 185 (2000–200 000) 0.27
 Gametocytaemia (%) 15 (9) 4 (2.6) 19 (5.9) 0.02
Parasite positivity
 On day 1 87 83 170 0.93
 On day 2 29 31 60 0.66
 On day 3 5 2 7 0.45
Parasite clearance time (day)
 Mean (95% CI) 1.8 (1.6–1.9) 1.8 (1.7–1.9) 1.8 (1.7–1.9) 0.88
PRRD1
 Geometric mean (95% CI) 923 (585–1456) 695 (421–1149) 805 (574–1129) 0.46
PRRD2
 Geometric mean (95% CI) 7428 (5298–10 415) 5143 (3407–7765) 6220 (4772–8108) 0.3
  1. PRRD1 Parasite reduction ratio 1 day after treatment initiation, PRRD2 Parasite reduction ratio 2 days after treatment initiation, CI Confidence interval