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Table 3 Predictors of residual asexual parasitaemia 1 day post-initiation of artemisinin-based combination treatments in acutely malarious children

From: Declining responsiveness of childhood Plasmodium falciparum infections to artemisinin-based combination treatments ten years following deployment as first-line antimalarials in Nigeria

Variable Total number Number with APPD1 OR (95% CI) P value aOR (95% CI) P value
Gender
 Female 615 339 1    
 Male 726 429 1.2 (0.9–1.5) 0.16
Age (month)
  > 24 963 550 1    
  ≤ 24 378 218 1.0 (0.8–1.3) 0.9
Temperature at presentation (°C)
  ≤ 37.4 409 234 1    
  > 37.4 932 534 1.0 (0.8–1.3) 1.0
Fever on day 1
 Absent 1189 712 1    
 Present 132 82 1.2 (0.8–1.8) 0.33
Haematocrit at presentation (%)
  < 30 728 425 1    
  ≥ 30 526 288 0.9 (0.7–1.2) 0.22
Haematocrit on day 1 (%)
  ≤ 27 275 140 1   1  
  > 27 640 384 1.4 (1.1–1.9) 0.01 1.6 (1.2–2.1) 0.002
Enrolment Parasitaemia (μl−1)
  ≤ 75 000 1148 631 1   1  
  > 75 000 193 137 2.0 (1.3–3) <  0.0001 1.9 (1.3–2.7) 0.002
Gametocytaemia
 Absent 1029 593 1    
 Present 188 115 1.2 (0.8–1.6) 0.41
Drug treatment
 AA 678 359 1    
 AL 663 409 1.4 (1.2–1.8) 0.001 1.8 (1.1–2.8) 0.01
Period of enrolment
 2009–2010 743 398 1    
 2014–2015 598 370 1.4 (1.1–1.8) 0.003 1.8 (1.4–2.4) <  0.0001
  1. APPD1 Asexual parasite positivity 1 day post-treatment initiation, OR Odd ratio, aOR Adjusted odd ratio, CI Confidence interval, AL Artemether-lumefantrine, AA Artesunate-amodiaquine