Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population

Table 2 Genotype frequencies of SNPs in the MBL2 gene among cases and controls and their associations with tuberculosis risk under a codominant genetic model

SNP ID	Genotype	Case (TB)		Control		P (2 df)^a	Logistic Regression
SNP ID	Genotype	No.	Frequency	No.	Frequency	P (2 df)^a	OR (95% CI)	P^b	P_adjusted^c
rs2099902	T/T	552	55.8%	323	63.8%	0.0025	1.000 (referent)
	C/T	372	37.6%	166	32.8%		2.364 (1.317–4.244)	0.004	0.256
	C/C	66	6.7%	17	3.4%		1.459 (1.143–1.863)	0.002	0.128
rs930507	C/C	549	57.3%	330	65.4%	0.0149	1.000 (referent)
	C/G	363	37.9%	157	31.1%		1.556 (1.215–1.992)	4.218E-4	0.027
	G/G	46	4.8%	18	3.6%		1.672 (0.921–3.038)	0.091	1.000
rs10824793	A/A	434	43.4%	259	51.2%	0.0171	1.000 (referent)
	G/A	459	46.0%	206	40.7%		1.466 (1.153–1.863)	0.002	0.128
	G/G	106	10.6%	41	8.1%		1.890 (1.245–2.870)	0.003	0.192
rs7916582	T/T	762	76.3%	398	79.3%	0.3794	1.000 (referent)
	T/C	223	22.3%	97	19.3%		1.338 (1.006–1.779)	0.045	1.000
	C/C	14	1.4%	7	1.4%		1.134 (0.424–3.034)	0.803	1.000

^aGlobal P values (2 degrees of freedom [df]): genotype frequencies in tuberculosis and control group were compared using a χ² test with two df
^bP values from unconditional logistic regression analyses, adjusted for age and gender
^cP_adjusted, P value with Bonferroni correction, P_adjusted value less than 0.05 was considered to be significant

ISSN: 2049-9957