Soluble IL-2Rα correlates with imbalances of Th1/Th2 and Tc1/Tc2 cells in patients with acute brucellosis

Table 1 Percentages of Th1, Th2, Tc1, and Tc2 from acute brucellosis samples pre-and post-treatment and healthy controls

	Pre-treatment (n = 21) Median (Q1–Q3)^f	Post-treatment (n = 21) Median (Q1–Q3)^f	Healthy control (n = 28) Median (Q1–Q3)^f	P-value^a pre- vs post-treatment
CD4 + IFN-γ+	19.2 (14.1–29.4) *	20.3 (11.6–29.7) *	14.0 (7.0–20.4)	ns^b
CD4 + IL-4+	0.8 (0.6–1.2) *	0.8 (0.6–1.2) *	0.3 (0.2–0.6)	ns
CD8 + IFN-γ+	51.0 (36.3–61.0) *	60.6 (42.7–63.9) *	39.0 (26.5–51.2)	ns
CD8 + IL-4+	1.8 (1.5–2.5) *	1.6 (1.0–1.7) *	0.8 (0.5–1.3)	0.0028
Treg^c	1.4 (0.9–2.1)	2.0 (1.2–2.5)	1.2 (0.8–2.2)	0.093
Th1/Th2 ratio^d	22.6 (15.8–28.7)*	23.8 (18.4–32.7)	37.4 (19.2–71.4)	ns
Tc1/Tc2 ratio^e	30.4 (14.1–35.0) *	39.0 (30.5–45.4)	50.7 (31.0–73.7)	0.0006

^aData was analyzed using Wilcoxon matched-pair signed-rank test
^bns, no significant difference
^cTreg, proportion of CD4⁺CD25⁺FoxP3⁺ T cells among CD4⁺ cells
^dTh1/Th2 ratio, ratio of peripheral CD4 + T cells producing IFN-γ (CD4 + IFN-γ+) to those producing IL-4 (CD4 + IL-4+)
^eTc1/Tc2 ratio, ratio of peripheral CD8 + T cells producing IFN-γ (CD8 + IFN-γ+) to those producing IL-4 (CD8 + IL-4+)
^fQ1 and Q3 represent the first and third quartiles, respectively
*Significant difference (p < 0.05) in comparison with healthy controls

ISSN: 2049-9957