Table 2 Univariate and multivariate Cox proportional hazard models of the time to virological suppression among 758 treatment-naïve patients initiating NNRTI-based ART. Variables were mutually adjusted in the multivariate model that included age
Variable | Crude | Adjusted | ||||
|---|---|---|---|---|---|---|
RH | (95% CI) | P | RH | (95% CI) | P | |
Male gender | 0.757 | (0.641–0.894) | 0.001 | 0.755 | (0.622–0.916) | 0.004 |
Year of ART Initiation | 0.981 | (0.839–1.148) | 0.812 | – | – | – |
Baseline RNA (copies/ml) | ||||||
< 100 000 | 1.000 | – | – | 1.000 | – | – |
100 000–500 000 | 0.628 | (0.532–0.741) | < 0.001 | 0.602 | (0.497–0.730) | < 0.001 |
≥ 500 000 | 0.477 | (0.349–0.652) | < 0.001 | 0.455 | (0.319–0.648) | < 0.001 |
Baseline CD4 (cells/m3) | ||||||
< 100 | 1.000 | – | – | 1.000 | – | – |
100–200 | 1.057 | (0.809–1.383) | 0.684 | 0.970 | (0.740–1.272) | 0.826 |
200–350 | 1.227 | (0.970–1.551) | 0.088 | 1.046 | (0.823–1.331) | 0.712 |
> 350 | 1.313 | (0.016–1.697) | 0.037 | 1.181 | (0.931–1.532) | 0.209 |
HBsAg (+) | 0.928 | (0.741–1.164) | 0.520 | – | – | – |
HCV-Ab (+) | 0.878 | (0.605–1.275) | 0.495 | – | – | – |
Mode of transmission | 0.910 | (0.722–1.147) | 0. | – | – | – |
Others | 1.000 | – | – | |||
Homosexual | 1.093 | (0.649–1.839) | 0.738 | – | – | – |
Heterosexual | 1.196 | (0.713–2.006) | 0.498 | – | – | – |
Bisexual | 0.804 | (0.408–1.582) | 0.527 | – | – | – |
Regimen | ||||||
Other 2NRTIs + NNRTI | 1.000 | – | – | – | – | – |
3TC + TDF + EFV | 0.963 | (0.790–1.175) | 0.711 | – | – | – |
3TC + AZT + NVP | 0.923 | (0.694–1.227) | 0.581 | – | – | – |
3TC + TDF + NVP | 0.669 | (0.383–1.167) | 0.157 | – | – | – |
3TC + AZT + EFV | 0.742 | (0.346–1.590) | 0.443 | – | – | – |
HIV subtype | 0.991 | (0.898–1.093) | 0.858 | – | – | – |
Resistance (low, intermediate and high) | 0.757 | (0.450–1.274) | 0.294 | – | – | – |