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Table 3 Drugs prescribed for MDR-PTB cases in present study

From: Efficacy of integrating short-course chemotherapy with Chinese herbs to treat multi-drug resistant pulmonary tuberculosis in China: a study protocol

Drug

Dosage form

Treatment per day

Weight < 50 kg

Weight ≥ 50 kg

Modern chemotherapeutic drugs

 Amikacin (Am)

Injection

0.40 g (once a day)

0.60 g (once a day)

 Moxifloxacin (Mfx)

Tablet

0.40 g (once a day)

0.40 g (once a day)

 Cycloserine (Cs)

Capsule

0.25 g (twice a day)

0.25 g (twice a day)

 Promethionine (Pto)

Tablet

0.30 g (twice a day)

0.40 g (twice a day)

 Pyrazinamide (Z)

Tablet

1.50 g (once a day)

1.50 g (once a day)

 Ethambutol (E)

Tablet

0.25 g (twice a day)

0.25 g (three times a day)

TCM compound

   

 No.1 compound

Granules

8.20 g (twice a day)

8.20 g (twice a day)

 No.2 compound

Granules

6.92 g (twice a day)

6.92 g (twice a day)

 No.3 compound

Granules

6.60 g (twice a day)

6.60 g (twice a day)

 No.4 compound

Granules

6.47 g (twice a day)

6.47 g (twice a day)

 No.1 placebo

Granules

8.20 g (twice a day)

8.20 g (twice a day)

 No.2 placebo

Granules

6.92 g (twice a day)

6.92 g (twice a day)

 No.3 placebo

Granules

6.60 g (twice a day)

6.60 g (twice a day)

 No.4 placebo

Granules

6.47 g (twice a day)

6.47 g (twice a day)

  1. No.1 TCM herb granule 1 will be will be formulated as mixed granules for single TCM herb administration and packed in food-grade plastic bags (8.20 g/bag), the granules will comprise extracts of Radix Astragali (Huang Qi) 20 portions, Rhizoma Curculiginis (Xian Mao) 4 portions, Fructus Rubi (Fu Pen Zi) 2 portions, Fructus Ligustri Lucidi (Nv Zhen Zi) 10 portions, Radix Rehmanniae (Di Huang) 10 portions, etc.
  2. No.2 TCM herb granule 2 will be will be formulated as mixed granules for single TCM herb administration and packed in food-grade plastic bags (6.92 g/bag), the granules will comprise extracts of Rhizoma Polygonati (Huang Jing) 6 portions, Rhizoma Atractylodis Macrocephalae (Bai Zhu) 5 portions, Radix Arnebiae (Zi Cao) 3 portions, etc.
  3. No.3 TCM herb granule 3 will be will be formulated as mixed granules for single TCM herb administration and packed in food-grade plastic bags (6.6 g/bag), the granules will comprise extracts of Rhizoma Imperatae (Bai Mao Gen) 15 portions, Gypsum Fibrosum (Shi Gao) 10 portions, Radix Arnebiae (Zi Cao) 6 portions, Herba Hedyoti Diffusae (Bai Hua She She Cao) 20 portions, etc.
  4. No.4 TCM herb granule 4 will be will be formulated as mixed granules for single TCM herb administration and packed in food-grade plastic bags (6.47 g/bag), the granules will comprise extracts of Radix Stemonae (Bai Bu) 6 portions, Spica Prunellae (Xia Ku Cao) 5 portions, Herba Violae (Zi Hua Di Ding) 5 portions, etc.
  5. TCM herb placebo (No.1 placebo, No.2 placebo, No.3 placebo and No.4 placebo) will be formulated using supplementary materials (starch, lactose, microcrystalline cellulose, talcum powder, caramel, bitter compounds, etc.), and it will be packed in food-grade plastic bags (8.20 g/bag, 6.92 g/bag, 6.60 g/bag, 6.47 g/bag, respectively)
  6. MDR-PTB Multidrug-resistant plumonary tuberculosis; TCM traditional Chinese medicine
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Infectious Diseases of Poverty

ISSN: 2049-9957

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