Fig. 3

Conceptual schematic for a mechanistic model of mass drug administration. There are three host classes, representing the mass drug administration-treated children, their families, and the broader community. Members of each host class move between four colonization states: uncolonized (X), colonized by the sensitive bacterial strain (S), colonized by the resistant strain (R) or co-colonized (SR). Colonization dynamics in each host class can affect dynamics in other classes: children frequently exchange bacteria with their families (thick arrow) but less often with the broader community (thin arrow)