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Table 1 Parameters likely required for mechanistic modeling of mass drug administration using bacterial transmission mechanics.

From: Uses of mathematical modeling to estimate the impact of mass drug administration of antibiotics on antimicrobial resistance within and between communities

Parameter class Number of parameters Notes
Transmission rates (β) N within-class and N-choose-2 between-class, where N is the number of host classes Values depend on both host contact rates and probabilities of bacterial transmission per contact
Antibiotic use rates (τ) 1 per antibiotic and host class More parameters are required if antibiotic use is explicitly time varying
Clearance rates (u) 1 per bacterial strain Background processes of immunity or competition are assumed to clear bacteria from hosts
Resistance costs (c) 1 or 2 per resistant bacterial strain Resistant strains are assumed to have lower transmission rates or higher clearance rates, relative to susceptible strains
Co-colonization parameters Varies depending on co-colonization mechanisms E.g., the model in Davies et al. [25] requires a co-colonization efficiency (k)
Initial conditions 1 per bacterial strain and host class Starting prevalence of each strain
Vital dynamics Varies depending on demographic model Birth rates, migration rates, etc
  1. The identity of these parameters and their notation was drawn from recent mechanistic models of use and resistance [25, 52, 58]