Table 1 Parameters likely required for mechanistic modeling of mass drug administration using bacterial transmission mechanics.
Parameter class | Number of parameters | Notes |
|---|---|---|
Transmission rates (β) | N within-class and N-choose-2 between-class, where N is the number of host classes | Values depend on both host contact rates and probabilities of bacterial transmission per contact |
Antibiotic use rates (τ) | 1 per antibiotic and host class | More parameters are required if antibiotic use is explicitly time varying |
Clearance rates (u) | 1 per bacterial strain | Background processes of immunity or competition are assumed to clear bacteria from hosts |
Resistance costs (c) | 1 or 2 per resistant bacterial strain | Resistant strains are assumed to have lower transmission rates or higher clearance rates, relative to susceptible strains |
Co-colonization parameters | Varies depending on co-colonization mechanisms | E.g., the model in Davies et al. [25] requires a co-colonization efficiency (k) |
Initial conditions | 1 per bacterial strain and host class | Starting prevalence of each strain |
Vital dynamics | Varies depending on demographic model | Birth rates, migration rates, etc |