Table 1 Two key neurovirulence determining sites revert in Henan aVDPV
Type | Region | Nucletide position | Sabin | CHN21006-1 | CHN21006-2 | CHN21006-3 | Amino acid position | Sabin | CHN21006-1 | CHN21006-2 | CHN21006-3 |
|---|---|---|---|---|---|---|---|---|---|---|---|
Serotype 3 | 5 ‘UTR | 472 | U | C | C | C | / | / | / | / | / |
VP3 | 2034 | U | U | U | U | 430 | Phe | Phe | Phe | Phe | |
VP1 | 2493 | C | U | U | U | 583 | Thr | Ile | Ile | Ile | |
Serotype 1 | 3D | 6203 | C | C | C | C | 1824 | His | His | His | His |