Table 1 The latest case definitions of the acute hepatitis of unknown aetiology by different guidelines
From: Acute hepatitis of unknown aetiology among children around the world
Institution | File name | Release date | Confirmed case | Probable case | Epi-linked case | Discarded case/Current patients under investigation |
|---|---|---|---|---|---|---|
WHO [2] | Severe acute hepatitis of unknown aetiology in children—multi-country | 12 July 2022 | NA | With an acute hepatitis; None Hep A–E; AST or ALT > 500 IU/L; 16 years and younger; Since 1 October 2021 | With an acute hepatitis; None Hep A–E; At any age; Close contact of a probable case; Since 1 October 2021 | NA |
ECDC [2] | Joint ECDC-WHO Regional Office for Europe Hepatitis of Unknown Origin in Children Surveillance Bulletin, 17 June 2022 | 29 July 2022 | NA | With an acute hepatitis; None Hep A–E; AST or ALT > 500 IU/L; 16 years and younger; Since 1 October 2021 | With an acute hepatitis; None Hep A–E; At any age; Close contact of a probable case; Since 1 October 2021 | Further investigations did not meet the case definition criteria |
UK Health Security Agency [4] | Investigation into acute hepatitis of unknown aetiology in children in England-Technical briefing 3 | 26 July 2022 England, Wales, Northern Ireland case definitions | With an acute hepatitis; None Hep A–E or an expected presentation of metabolic, inherited or genetic, congenital or mechanical cause; AST or ALT > 500 IU/L; 10 years old and younger; Since 1 January 2022 | With an acute hepatitis; None Hep A–E or an expected presentation of metabolic, inherited or genetic, congenital or mechanical cause; AST or ALT > 500 IU/L; 11 to 15 years old; Since 1 January 2022 | With an acute hepatitis; None Hep A–E or an expected presentation of metabolic, inherited or genetic, congenital or mechanical cause; Close contact of a confirmed case; Since 1 January 202 | NA |
UK Health Security Agency [4] | 26 July 2022 Scotland case definition | AST or ALT > 500 IU/L without any known cause, 10 years of age and younger or a contact of any age of a confirmed case; Since 1 January 2022 Excluding hepatitis, A–E, cytomegalovirus and Epstein-Barr virus | NA | NA | NA | |
United States [3] | Technical Report: Acute Hepatitis of Unknown Cause | 17 August 2022 | NA | NA | NA | 10 years of age and younger; AST or ALT > 500 U/L; Have an unknown etiology for hepatitis (with or without any adenovirus testing results, irrespective of the results) Since October 1, 2021 |