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Table 3 Mediation effects of socioeconomic factors on infectious diseases by lifestyle, environmental pollution or chronic comorbidity factors in UK Biobank

From: Associations of socioeconomic status with infectious diseases mediated by lifestyle, environmental pollution and chronic comorbidities: a comprehensive evaluation based on UK Biobank

Outcome

Exposure

Mediator

Effect with mediator adjusted (95% CI)

Indirect effect by mediator (95% CI)

Mediation proportion (%) (95% CI)

P

Infectious diseases

SES

Lifestyle scores

1.4895 (1.4646–1.5148)

1.0008 (1.0008–1.0009)

2.9 (2.6–3.3)

 < 0.001

CVD

1.4815 (1.4610–1.5023)

1.0018 (1.0016–1.0019)

5.9 (5.5–6.3)

 < 0.001

Diabetes

1.5081 (1.4873–1.5291)

1.0006 (1.0005–1.0007)

2.0 (1.8–2.2)

 < 0.001

Psychiatric disorders

1.5338 (1.5127–1.5551)

1.0002 (1.0002–1.0003)

0.7 (0.6–0.8)

 < 0.001

Cancer

1.5366 (1.5155–1.5580)

1.0002 (1.0001–1.0002)

0.6 (0.3–0.8)

 < 0.001

TDI

EPS group

1.0708 (1.0673–1.0743)

1.0002 (1.0000–1.0004)

2.3 (0.3–4.3)

0.014

Respiratory infectious diseases

SES

Lifestyle scores

1.4835 (1.3508–1.6302)

1.0016 (1.0008–1.0024)

4.1 (2.1–6.6)

 < 0.001

CVD

1.4757 (1.3656–1.5953)

1.0027 (1.0019–1.0037)

6.8 (4.7–9.8)

 < 0.001

Diabetes

1.5103 (1.3982–1.6321)

1.0009 (1.0004–1.0014)

2.2 (1.1–3.6)

 < 0.001

Psychiatric disorders

1.5465 (1.4323–1.6706)

1.0001 (0.9997–1.0004)

0.2 (− 0.7–1.0)

0.576

Cancer

1.5485 (1.4339–1.6730)

1.0001 (0.9993–1.0007)

0.2 (− 1.7–1.7)

0.804

TDI

EPS group

1.0606 (1.0418–1.0797)

1.0015 (1.0001–1.0028)

12.7 (1.4–25.7)

0.028

Digestive infectious diseases

SES

Lifestyle scores

1.4466 (1.3971–1.4979)

1.0011 (1.0009–1.0013)

2.9 (2.3–3.7)

 < 0.001

CVD

1.4313 (1.3907–1.4732)

1.0025 (1.0021–1.0028)

6.4 (5.5–7.4)

 < 0.001

Diabetes

1.4511 (1.4100–1.4936)

1.0011 (1.0009–1.0013)

2.7 (2.2–3.3)

 < 0.001

Psychiatric disorders

1.4830 (1.4413–1.5261)

1.0003 (1.0001–1.0005)

0.7 (0.3–1.2)

 < 0.001

Cancer

1.4851 (1.4433–1.5283)

1.0002 (1.0000–1.0004)

0.5 (0.1–1.0)

0.018

TDI

EPS group

1.0641 (1.0571–1.0711)

0.9999 (0.9994–1.0003)

− 1.4 (− 6.2–3.1)

0.584

Blood or sexually transmitted infectious diseases

SES

Lifestyle scores

2.4246 (2.0957–2.8124)

1.0015 (1.0004–1.0027)

3.3 (1.0–6.0)

0.004

CVD

2.3007 (2.0435–2.5945)

1.0010 (1.0005–1.0017)

2.0 (1.1–3.5)

 < 0.001

Diabetes

2.3386 (2.0780–2.6363)

1.0006 (1.0001–1.0012)

1.1 (0.3–2.5)

0.002

Psychiatric disorders

2.3447 (2.0844–2.6422)

1.0011 (1.0003–1.0020)

2.2 (0.6–4.1)

0.012

Cancer

2.3866 (2.1208–2.6905)

1.0005 (0.9996–1.0014)

1.1 (− 0.8–2.9)

0.242

TDI

EPS group

1.1350 (1.1056–1.1654)

0.9995 (0.9972–1.0018)

− 2.6 (− 14.5–9.2)

0.642

Infectious diseases in 2010

SES

Lifestyle scores

1.4439 (1.3864–1.5039)

1.0005 (1.0004–1.0007)

2.0 (1.5–2.8)

 < 0.001

CVD

1.4129 (1.3657–1.4618)

1.0019 (1.0016–1.0022)

7.1 (6.1–8.4)

 < 0.001

Diabetes

1.4400 (1.3920–1.4896)

1.0006 (1.0005–1.0008)

2.3 (1.8–2.9)

 < 0.001

Psychiatric disorders

1.4642 (1.4157–1.5145)

1.0002 (1.0002–1.0004)

0.9 (0.6–1.3)

 < 0.001

Cancer

1.4656 (1.4170–1.5161)

1.0003 (1.0001–1.0005)

1.0 (0.2–1.7)

0.014

TDI

EPS group

1.0617 (1.0531–1.0704)

0.9999 (0.9995–1.0002)

− 1.5 (− 7.0–3.4)

0.568

  1. Effect and proportion estimations and P values were adjusted for age, sex, ethnic and assessment center
  2. TDI Townsend deprivation, SES socioeconomic status, EPS environment pollution score, CVD cardiovascular disease