Table 3 Immunological factors measured in plasma associated with death among cerebral malaria infants, multivariate logistic regression
Factors | Â | Survival, % (n) | Death, % (n) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|---|
OR (95% CI) | P-value | aOR (95% CI) | P-value | ||||
TNF (pg/ml) |  < 41.4 | 79.4 (27) | 20.6 (7) | 1 |  |  |  |
|  |  ≥ 41.4 | 62.9 (22) | 37.1 (13) | 2.27 (0.78–6.69) | 0.13 |  |  |
IL-8 (pg/ml) |  < 57.5 | 91.7 (33) | 8.3 (3) | 1 |  | 1 |  |
|  |  ≥ 57.5 | 48.5 (16) | 51.5 (17) | 11.7 (2.98–45.8) | 0.004 | 14.2 (2.56–78.4) | 0.002 |
IL-10 (pg/ml) |  < 541.2 | 80.0 (28) | 20.0 (7) | 1 |  |  |  |
|  |  ≥ 541.2 | 61.8 (21) | 38.2 (13) | 2.48 (0.84–7.28) | 0.10 |  |  |
CCL2 (pg/ml) |  < 172.9 | 78.8 (26) | 21.2 (7) | 1 |  |  |  |
|  |  ≥ 172.9 | 60.6 (20) | 39.4 (13) | 2.41 (0.81–7.17) | 0.11 |  |  |
Angiopoietin-2 (pg/ml) |  < 17,774 | 88.6 (31) | 11.4 (4) | 1 |  |  |  |
|  |  ≥ 17,774 | 52.9 (18) | 47.1 (16) | 6.89 (1.99–23.8) | 0.002 |  |  |
CCL4 (pg/ml) |  < 336.6 | 78.1 (25) | 21.9 (7) | 1 |  |  |  |
|  |  ≥ 336.6 | 61.8 (21) | 38.2 (13) | 2.21 (0.75–6.55) | 0.15 |  |  |
CXCL9 (pg/ml) |  < 1823.1 | 80.6 (25) | 19.4 (6) | 1 |  |  |  |
|  |  ≥ 1823.1 | 56.2 (18) | 43.7 (14) | 3.24 (1.04–10.1) | 0.04 |  |  |
Granzyme B (pg/ml) |  < 792.4 | 87.5 (28) | 12.5 (4) | 1 |  |  |  |
|  |  ≥ 792.4 | 53.3 (16) | 46.7 (14) | 6.12 (1.72–21.8) | 0.005 |  |  |