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Table 2 Studies on socioeconomic position (SEP) and malaria with analysis approaches

From: What are the pathways between poverty and malaria in sub-Saharan Africa? A systematic review of mediation studies

Author year

Analyses performed

Risk estimate (95% CI) and result of mediation (if any)

Adjusted for confounders/mediators

Quality score

Siri 2010

Multivariable logistic regression

OR. wealth percentile [0.8 (0.7–0.9)]

ITN use, mosquito coils, age, location, gender of HH head

Strong

Coleman et al. 2010

Multivariable negative binomial regressions

OR. Reference (the 1st quartile) third [0.24 (0.09–0.65)], and fourth (least poor) [0.27 (0.10–0.79)]

Housing structure, closing windows on retiring

Strong

Loha et al. 2012

Poisson regression

(Beta coefficient = − 0.155, P-value = 0.043)

Age, gender, ITN use, and distance to the breeding place

Strong

Clark et al. 2008

Generalized estimating equations with control for repeated measures

IRR. Reference (SEP quartiles 1 and 2 combined). Third [0.83 (0.62–1.10)], fourth [0.77 (0.56–1.04)]

Age, gender, ITN use, distance to the swamp, household crowding

Strong

Snyman et al. 2015

Negative binomial regression models

IRR. Reference (lowest). Middle [0.91 (0.76–1.1)], highest [0.86 (0.72–1.03)]

Caregiver’s age, education, house construction, location, number of rooms

Moderate

Tusting et al. 2016

Multivariable logistic regression and causal steps approach-simulations and Bootstrapping

IRR. Reference (lowest), middle [1.12 (0.90–1.40)], highest [1.05 (0.83–1.34)]

Housing type explained 24.9% of the SEP effect, and food security explained 18.6%

Age, gender, level of education, housing typea, food securitya, distance to facility, household size

Strong

Wanzirah et al. 2015

Multivariable logistic regression and negative binomial regression

OR. Reference (1st tertile)

Walukuba: 2nd tertile [0.82 (0.38–1.78)], 3rd tertile [0.83 (0.31–2.18)]

Kihihi: 2nd tertile [0.54 (0.28–1.06)], 3rd tertile [0.37 (0.20–0.71)]

Nagongera: 2nd tertile [0.72 (0.50–1.04)], 3rd tertile [0.71 (0.47–1.07)]

Age, gender, house type, floor material, roof material, eaves

Moderate

Asante et al. 2013

Cox proportional hazards regression

HR. Reference (least poor), less poor [1.54 (1.23–1.93)], poor [1.88 (1.50–2.35)], poorer [1.86 (1.50–2.31)], most poor [2.21 (1.77–2.76)]

Housing (thatched roof), location, distance to the health facility, ITN use

Strong

Haji et al. 2016

Multivariable logistic regression

OR. Reference (low), medium [1.51 (0.51–4. 45)], high [0.93 (0.35–2.45)]

Location, ITN use, age of the child, gender, sought advice before, knowledge of malaria

Moderate

Kabaghe et al. 2017

Modified Poisson regression

HPD. SEP [− 0.07 (− 0.11 to − 0.03)]

Age, ITN use, elevation and Normalized Difference Vegetation Index

Weak

Mathanga et al. 2015

Multivariable logistic regression

OR. Reference (poorest), poor [1.08 (0.82–1.42)], medium [1.30, 0.98–1.72)], less poor [1.26 (0.94–1.70)], least poor [0.74 (0.55–0.99)]

Age, gender, ITN use, reported fever, education status, household size, school feeding)

Moderate

Sakwe et al. 2019

Multivariable logistic regression

OR. Development Index [0.76 (0.58–0.99)]

Child age, gender, nutrition status, housing type, HH size, HH head education, and caregiver

Moderate

Skarbinski et al. 2011

Multivariable logistic regression

OR. Reference (least poor), 4th [2.10 (1.45–3.05)], 3rd [2.64 (1.80–3.87)], 2nd [2.84 (2.03–3.97)], 1st [3.46 (2.30–5.21)]

District, ITN use, IRN use

Weak

Skarbinski et al. 2012

Binomial regression modelling

OR. Reference (least poor), 4th [1.19 (0.71–2.00)], 3rd [1.72 (1.09–2.70)], 2nd [1.52 (1.01–2.29)], 1st [1.47 (0.98–2.20)]

IRS use, ITN use, wall material, roof material

Weak

Somi et al. 2007

Probit regression

Coefficients: SEP score based on PCA (numerical) = − 0.04 (P-value = 0.012)

ITN use, age, location, knowledge, eaves

Moderate

Somi et al. 2008

Probit regression

Coefficients: SEP score based on PCA (numerical) = − 0.074

Age, location, ITN use, HH size, eaves, knowledge

Moderate

Ssempiira et al. 2017

Bayesian geostatistical logistic regression

OR. Reference (poorest), richest [0.19 (0.14, 0.27)], richer [0.52 (0.42, 0.61)], medium [0.77 (0.85, 1.15)], poorer [0.86 (0.72, 1.04)]

Location, ITN use, IRS use, age, mothers’ education, land surface temperature

Moderate

Temu et al. 2012

Multivariable logistic regression

OR. Reference (poorest), 2nd quartile [0.9 (0.7–1.2)], 3rd quartile [0.9 (0.7–1.3)], and 4th quartile [0.5 (0.4–0.7)]

Age, year, ITN use, HH size, house construction, children with current fever

Weak

Zoungrana et al. 2014

Multivariable logistic regression

OR. Reference (high)

Low SEP [4.11 (1.44, 11.75)]

Age, gender, marital status, education, knowledge, ethnicity, residence, distance, travel time, HH size, decision making

Strong

Graves et al. 2009

Multivariable logistic regression

OR. Asset index [0.79 (0.66—0.94)]

Age, gender, altitude, monthly rain, ITN use, IRS use in the last 12 months

Moderate

Mmbando et al. 2011

Muitivariate logistic regression

Spatial analysis

OR. Reference (high), medium [1.6(1.3–1.9)], low [1.6 (1.4–1.91)]

Age, ITN use, ITN rate, housing, year, altitude

Moderate

Siri 2014

Multilevel logistic regression

OR. Wealth percentile [0.990 (0.987–0.992)]

Child age, mother’s age, ITN use, country, HH size, location, education, finished windows and ceilings

Moderate

Custodio et al. 2009

Multivariable logistic regression

OR. Reference (low), medium [0.97 (0.29–3.25)], high [0.15 (0.05–0.50)]

ITN use, antimalarials use in pregnancy, age, gender

Moderate

de Beaudrap et al. 2011

Multivariable logistic regression

OR. SEP score [0.75 (0.64–0.89)]

Child age, weight, housing score, ITN use, education and latitude

Moderate

Sonko et al. 2014

Multivariable logistic regression

For children 6–59 months, OR. Reference (poorest), 2nd [0.40 (0.20–0.70], 3rd [0.5 (0.30–0.90)], 4th [0.30 (0.10–0.60), 5th [0.10 (0.04–0.30)]

Children 5–14 years

2nd [0.60 (0.30–1.20]), 3rd [0.70 (0.50–1.10]), 4th [0.20 (0.10–0.50)], 5th [0.30 (0.10–0.60)]. For the general population

2nd [0.80 (0.40–1.30)], 3rd [0.80 (0.50–1.20), 4th (0.40 (0.20–0.80), 5th [0.20 (0.07–0.80)]

Housing (wall type, roof type, floor type, window type,) age, gender

Moderate

Chirombo et al. 2014

Structured additive logistic regression (Bayesian approach)

OR. Reference (poorest), richest [0.22 (0.14–0.37)], richer (0.42 (0.28–0.64)], medium [0.66 (0.45–0.96)], poorer [1.10 (0.76–1.60)]

ITN use, region, age and location

Weak

de Glanville et al. 2019

Multivariable logistic regression

Mediation analysis using a hierarchical approach

OR. SEP [0.76 (0.66–0.86)]

Minimal mediation by antimalarial use

Gender, age, access to health care (antimalaria usea)

Moderate

Florey et al. 2012

GEE models with exchangeable correlation matrix and logistic distributions

OR. SEP [0.76 (0.54–1.05)]

Outdoor night activity

Weak

Kahabuka et al. 2012

Multivariable logistic regression

OR. Reference (high), middle [1.00 (0.40–2.80)], and low [1.20 (0.40–3.70)]

Education, parity, hospital travel time, use of near public health facility, source of the first treatment

Weak

Ma et al. 2017

Multivariable logistic regression

OR. SEP [1.20 (0.94–1.50)]

Study site, age, HH size, education, HIV Status, ITN use, phone ownership

Moderate

West et al. 2013

Multivariable logistic regression

OR. Reference (poorest), mild [0.69 (0.34–1.40)], least poor [0.13 (0.05–0.34)]

HH spaying, cluster ITN coverage, age

Moderate

Williams et al. 2016

Multivariable logistic regression

OR. Reference (wealthiest), wealthy [1.82 (0.68–4.83)], medium [0.96 (0.18–5.02)], poor [6.48 (1.68, 25.0), poorest [6.55 (1.27–33.70)]

Education, age, gestation age, gravidity, country

Weak

Zgambo et al. 2017

Multivariable logistic regression

OR. Reference (richest), 2012 survey: poorest [2.90 (1.60–5.30)], poorer [2.3 (1.10–4.60)], middle [2.50 (1.30–5.00)], richer [1.9 (1.10–3.60)]

2014 survey: poorest [4.7 (1.3–16.2)], poorer [2.9 (0.9–10.0)], middle [2.7 (0.7–10.2)], richer [1.9 (0.4–8.0)]

ITN use, ITN ownership, IRS, region, location, Gender, child age, altitude, and education of the mother

Moderate

Gari T et al. 2016

A multilevel mixed effects Poisson regression

IRR. Reference (rich). Poor [0.94 (0.35–2.45)], medium [0.70 (0.33–1.50)]

Age, gender, HH head education, ITN use

Strong

Liu et al. 2014

Multivariable negative binomial regressions

IRR. Reference (middle). Poorest [1.316 (0.915–1.891)], poorer [1.292 (0.876–1.905)], richer [1.090 (0.667–1.782)], richest [1.059 (0.533–2.103)]

Age, housing index, regular repellent use, ITN use, location, water source, electricity

Strong

Vincenz et al. 2022

GEE for binary logistic regression

OR. [1.37 (0.99–1.91)]

Maternal age, gravidity, IPTP use, education, season

Weak

Mann et al. 2021

Multivariable logistic regression

OR. Reference (richest), poorest [4.60 (3.05–6.96)], poorer [4.18 (2.81–6.19)], middle [3.27 (2.26–4.71)], richer [2.23 (1.55–3.21)]

Age, gender, residence, education, nutrition (stunting)

Moderate

Emina et al. 2021

Generalized estimating equations with control for repeated measures

OR. Reference (poorest), poorer [1.20 (0.95–1.52)], middle [1.00 (0.77–1.31)], richer [0.69 (0.50–0.96)], richest [0.19 (0.10–0.37)]

Gender, child’s age, mother education, ITN use, sex of HH head, type of residence, province of residence

Moderate

Mwaiswelo et al. 2021

Multivariable logistic regression

OR. Reference (low). Medium [0.54, 0.36–0.83)], upper [0.41(0.25–0.66)]

ITN ownership, HH size, education, district (location)

Weak

Mangani et al. 2022

Multilevel logistic regression

OR. Reference (poorest), poorer [0.80 (0.65–1.00)], middle [0.74 (0.56–0.99)], richer [0.80 (0.62–1.01)], richest [0.64 (0.50–0.81)]

HH wall, roof materials, education, ITN use, child’s age, gender, distance from the irrigation scheme

Moderate

Ejigu 2020

Geostatistical logistic model

OR. Reference (poorest), poorer [0.99 (0.80–1.25)], middle [0.67 (0.53–0.85)], richer [0.52 (0.40–0.69)], richest [0.19 (0.11–0.31)]

Province, mothers’ education, anemia, ITN use, age in months, ITN coverage, malaria incidence

Weak

  1. CI confidence interval, GEE generalized estimating equations, HH household, HPD highest posterior density, PCA principal component analysis, OR odds ratios, IRR incidence rate ratios, ITN insecticide treated net, IRS indoor residual spraying
  2. aMediators assessed in formal analyses