Combating infectious diseases of poverty: a year on
Infectious Diseases of Poverty volume 2, Article number: 27 (2013)
The Infectious Diseases of Poverty journal, launched a year ago, is a platform to engage outside the traditional disciplinary boundaries, and disseminate high quality science towards the improvement of health. This paper reviews the milestone achievements during its first year of operation. The journal has filled an important niche, addressing some of the main priorities in the Global Report for Research on Infectious Diseases of Poverty. Highlights include the publication of three thematic issues on health systems, surveillance and response systems, as well as co-infection and syndemics. The thematic issues have foregrounded the importance and innovation that can be achieved through transdisciplinary research. The journal has been indexed by PubMed since April 2013, with the publication of a total of 38 articles. Finally, the journal is delivering to wider range readers both in developing and developed countries with sustained efforts with a focus on relevant and strategic information towards elimination of infectious diseases of poverty.
Please see Additional file1 for translation of the abstract into the six official working languages of the United Nations.
Infectious diseases are inextricably linked to populations living in the poor conditions[1, 2]. This remains the case with emerging infections and with the re-emergence of infectious diseases for which prevention and cures have been successful in other populations[3, 4]. Challenges persist with the dynamic evolution of our ecology and the disease agents, including pathogens, vectors, as well as biological, social, cultural, political and environmental factors. Although there are rapid technological and scientific developments that propose solutions to some aspects of diseases of poverty, current paradigms in research still struggle with the balance of integration of the knowledge produced by the growing numbers of disciplines that are able to contribute to our understanding of the complexity in health and disease[5–7]. Furthermore, mechanisms for the sharing and translation of knowledge into policies and effective practice needs to be given greater priority, particularly to improve access to low and middle income countries that have the highest endemicity[8, 9].
Infectious Diseases of Poverty (IDP), http://www.idpjournal.com, was launched on 25 October 2012 at the 2nd Global Symposium on Health Systems Research held in Beijing, with the specific purpose to foster interdisciplinary and transdisciplinary research that explicitly highlights the intersection of poverty and other ecological factors with disease. The IDP journal provides a forum for researchers to engage outside the traditional disciplinary boundaries and for policy makers to find and disseminate high quality science towards the improvement of the health of vulnerable populations. The journal encourages publications that aim:
to identify and assess the research base underlying important current and future public health options, choices and decisions;
to highlight information gaps and research gaps;
to review a wide range of topic areas, methods and strategies in diseases of poverty; and
to facilitate a much needed dialogue between policy makers, public health practitioners, control staff and academic researchers and their donors.
The IDP journal builds on knowledge translation activities initiated by the UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases (TDR), especially within the TropIKA.net initiative. In November 2011, the National Institute of Parasitic Diseases (NIPD) of Shanghai, People’s Republic of China, hosted a Consultation on setting up an international Partnership for TropIKA.net as the initiative was being phased out by TDR. The IDP journal was one of the three priority areas identified by the participants and NIPD took the lead in establishing the journal in collaboration with the open access publisher, BioMed Central (BMC).
The IDP Journal takes on the unique mission "One health - One world" put forward by the Global Report for Research on Infectious Diseases of Poverty (Global Report). The mission of the journal is expressed in its logo (Figure 1), which consists of three components: (i) the worm (schistosoma) represents infectious diseases; (ii) the distorted house around the worm represents poverty and environmental challenges; (iii) the whole image is akin to an outdated wax seal, which indicates a persistent problem in need of innovative solutions. This editorial summarizes the progress of the journal after one year of publication.
The breadth and depth of issues covered
A total of 15 diseases were covered by the 38 free online and open access articles, ranging from TB, HIV/AIDS, schistosomiasis, malaria, H7N9 influenza, and clonorchiasis to co-infections with non-communicable diseases and with pregnancy. Several neglected tropical diseases were also addressed such as babesiasis, leishmaniasis, echinococcosis, helminth infections, avian influenza, rabies, trachoma, buruli ulcer, diabetes, and cholangicarcinoma, etc. (Figure 2).
Three thematic issues were published: (i) Health Systems Research for Infectious Diseases of Poverty; (ii) Surveillance and Response to Infectious Diseases of Poverty; and (iii) Co-infection and Syndemics. All of them covered transdisciplinary research, ecohealth approaches, and translational sciences to combat the infectious diseases of poverty.
In the first thematic issue entitled “Health Systems Research for Infectious Diseases of Poverty”, the main purpose of the collection was to review the recent progress on the roles of the health systems in combating the infectious diseases of poverty in order to call for more research on health systems[11, 12]. The 12 articles emphasized the essential characteristics of poverty and provided evidence on technical solutions to managing the infectious diseases that afflict poor populations world-wide[13, 14]. The articles discussed treatments, indicating the importance of pharmaceuticals for neglected diseases, as well as delivery strategies to reach impoverished populations, and highlighted the lack of research on (i) innovative programs that provide diagnostics and treatment for infectious diseases to hard-to-reach rural and urban communities, (ii) exploring research on other health system components, and (iii) broadening the evidence base to increase understanding of effective and sustainable interventions to reduce the burden of infectious disease among the poor.
The collection of papers on “Surveillance and Response to Infectious Diseases of Poverty”, published 15 articles from traditional neglected tropical diseases to the newly outbreaks of H7N9 flu that make international impact significantly[13, 15]. Based on the innovative and effective "One health - One world" paradigm, six different research priorities were recommended, including (i) dynamic mapping of transmission; (ii) capture of population dynamics; (iii) modeling based on a minimal and essential database approach; (iv) implementation of mobile-health (m-health) and sensitive diagnostics; (v) design of response packages tailored to different transmission settings and levels; and (vi) validation of approaches and responses, all of which were outcomes of the First Forum on Surveillance Response System Leading to Tropical Diseases Elimination, which was held in Shanghai in June 2012.
In the third thematic issue, entitled “Co-infection and Syndemics”, a total of six articles were published on co-infections or syndemics between HIV/AIDS, tuberculosis, malaria, and other neglected tropical diseases, such as intestinal parasitic infections, schistosomiasis, babesiasis, clonorchiasis, and diabetes, etc.[16–19]. In fact, co-infection is of particular human health importance because pathogenic agents can interact within the host, while syndemics refers to the aggregation of two or more diseases in a population, that can be expanded further to situate the occurrence of multiple diseases within the context of poverty and other mitigating factors that support and perpetuate poor health. Given that social conditions can contribute to the clustering, form and progression of a disease at both individual and population levels, it is a great challenge to understand the processes that generate these patterns of co-infection and syndemics.
All three thematic issues have trigged more research on exploring innovative and transdisciplinary approaches, which could be applied in the resource limited settings or in the field of better medical and public health interventions in the poor population.
Achieving the agenda for action proposed by the Global Report
In face of challenges in infectious diseases of poverty for control programmes, the Global Report emphasized the need to break the vicious cycle between poverty and infectious diseases, and to forge an escape for the poor and vulnerable population through the uptake of global health research solutions. A total of five options for action were put forward by the Global Report as high level priorities[20, 21].
Among the 38 articles in the first two issues of Infectious Diseases of Poverty, some articles were responding to those five options for action as advocated in the Global Report.
The option for action 1 (see Table 1), for instance, “Create and use a new index of infectious diseases of poverty to serve as a surrogate marker of national socioeconomic development” calls for doing research on defining new indices based on current prevalence of infectious diseases to inform policy maker on where resources are needed, which control effort are to be put in place, when should intervention be implemented, where the research activities be prioritized, and how to use them to evaluate and monitor the control programmes, etc. During the past year, four articles reported on disease burden by measuring impact of diseases at local, national and global levels[12, 15, 19, 22], three articles described how to measure the ability of the health systems to predict, prevent and deal with disease outbreaks and to deliver effective interventions[11, 12, 14]; two articles dealt with the government commitment to tackle the problems on infectious diseases of poverty[23, 24]; and three articles focused on socioeconomic factors to measure determinants of health[17, 25, 26].
The option for action 2 calls for policy-makers, funders and academic community to embrace a "One health - One world" strategy, in particular, to foster essential multidisciplinary and multisectoral approaches for a full continuum of research. In this regard, four researchers had linked with governments of disease endemic countries that develop intersectoral frameworks and encourage cooperation in the field of zoonosis[19, 27–29], and additional four investigations had highlighted the collaboration across various ministries as well as among medical and veterinary doctors[13, 22, 30, 31].
In the option for action 3, four articles had worked on developing research congruent with the burden of infectious diseases of poverty in their own populations[26, 32–34], three articles demonstrated an increase in research activities and improved research leadership[14, 30, 31], three articles were trying to develop regional partnerships aiming for building research infrastructure, human resources and research capacity[22, 32, 35], and two articles focused on how to create policies and develop plans to guide international investments towards the identified research priorities[13, 36]. However, there is still a significant need to increase national investment for research and the translation of research to strategies for health[31, 35].
Unfortunately, to date, there has not yet been any publications related to the option for action 4 and the option for action 5. We hope the readers are able to promote this kind of research, and enhance this field with the development of the journal. It is expected that the global platform would be populated by information from multiple sources and provide a database for research on infectious diseases of poverty[4, 37]. In particular we would strongly encourage and promote more research or review articles to be published on the issues of 10 reasons to do research on infectious diseases of poverty and research solutions for global health, which were raised by the Global Report (Table 2).
It is interesting to note that the top five highly accessed articles reached more than 3,000 visits for each article, and up to 10,000 visits of the top one. Among the top five articles, three articles are related to the transdisciplinary approaches with targeting cross-cutting issues, such as environmental changes, social determinants and health system[27, 38, 39]. Another two articles put forward the research priorities based on the gap analysis between control programmes and research capacity, in the field of malaria, schistosomiasis, and echinococcosis[24, 34].
Success in editorial process
In the first two inaugural volumes from October 2012 to October 2013, IDP journal attracted strong submissions and developed a readership within the BMC model, including (i) open-access for readers, (ii) high quality of published work, and (iii) a professional and transparent editorial process.
The open-access model allows wide penetration and dissemination into low income settings. A total of 38 publications have been online in the first and second volumes of IDP journal in the first year, with the 6 types of articles including research articles accounting for 50.0% of total publications, followed by scoping reviews (23.7%), opinion pieces (13.2%), commentaries (5.3%), editorials (5.3%), and letters to the editor (2.6%) (Figure 3). A total of 145 authors or co-authors were presented in 38 publications, whose geographic distribution showed were mainly from Asia (53.1%) and Africa (24.1%), followed by Europe (13.1%), North America (7.6%), Oceania (1.4%) and Lain America (0.7%). About 3.2 institutions in average involved in each articles, which mainly cooperated through south–north model accounting for 47.4%, followed by south-south cooperation (28.9%), and north-north cooperation (10.5%) (Figure 4). Therefore, the south-south cooperation in the field of infectious diseases of poverty needs to be further strengthened (Additional file2).
Scientists from 39 countries have submitted their manuscripts to this journal, in which Africa and Asia accounting for 39% and 37% of the total number of submitted manuscripts, respectively, followed by Latin America (10%), Oceania (5%), North America (4%), and Europe (4%). While the visits came from the whole of the world, and the top ten countries for visiting the journal are ordered by following countries: United States, China, India, Nigeria, Australia, United Kingdom, Philippines, Pakistan, South Africa, which indicating 70% of visits from low and middle income countries (Additional file2).
Secondly, the high quality of publications has been demonstrated in the first year. For example, some of publications have been cited more than 3 times from the Thomson Reuters database and more than 5 times from the Google Scholar database during less than one year. The journal has also maintained a high level of rigor in the peer review process. Approximately 35% of submission currently passed the peer review process. Manuscripts accepted were from Europe (40%) and North America (40%), followed by Asia (38%), Africa (20%), and Oceania (17%). This kind of publication quality was contributed by an excellent mix of experts from disease-endemic countries as well as leading research institutions in high-income countries, with a total of 51 editorial board members. Most of editorial board members had experiences serving the think tank in WHO/TDR for the Global Report, they are selected from Europe (23.5%), Africa (21.6%), Asia (21.6%), Latin America (11.8%), North America (11.8%), and Oceania (9.8%) (Figure 5). There is a good gender balance and several yong scientists have joined the board (Additional file2).
Thirdly, professional editorial process has increased the efficiency in production of all publications. Two special efforts were made by the editorial team. One is that the abstract of each publication was translated into 6 UN working languages. The other one is the short time of efficient peer review for the decision and publication, with average time was about 65 days and 25 days, respectively. Those efforts have been apprased by authors widely. A strong commitment by the editoiral office in China to this work is demonstrated by the waiving of article processing costs in the initial stage of the new journal until the end of 2014, and this is to ensure that researchers who have innovative ideas for transdisciplinary research are able to disseminate their ideas based on the quality of the science and without being hindered by cost restrictions.
The journal fills an important niche, in line with the high-level Global Report put forth by the World Health Organization in 2012. The journal was indexed by PubMed in April 2013, and the next logical step is to obtain an official impact factor through ISI Web of Knowledge. The journal has already established itself as an important outlet and holds promise of becoming a leading and influential journal in the field of global health and infectious diseases in future years. The data from co-authors’ institutions indicated the south-south cooperation need to be further strengthen in the future. We look forward to delivering on this promise to our acknowledged authors and wide readers with sustained efforts by professional editorial team. It is expecting more readers to publish their research or review articles on the issues of 10 reasons to do research on infectious diseases of poverty and research solutions for global health, proposed by the Global Report.
TDR: Global Report for Research on Infectious Diseases of Poverty. 2012, Geneva: World Health Organization
Bonds MH, Keenan DC, Rohani P, Sachs JD: Poverty trap formed by the ecology of infectious diseases. Proc Biol Sci. 2010, 277 (1685): 1185-1192. 10.1098/rspb.2009.1778.
Hotez P, Stillwaggon E, McDonald M, Todman L, DiGrazia L: National summit on neglected infections of poverty in the United States. Emerg Infect Dis. 2010, 16 (5): e1-10.3201/eid1605.091863.
Gyapong JO, Gyapong M, Yellu N, Anakwah K, Amofah G, Bockarie M, Adjei S: Integration of control of neglected tropical diseases into health-care systems: challenges and opportunities. Lancet. 2010, 375 (9709): 160-165. 10.1016/S0140-6736(09)61249-6.
Manderson L, Aagaard-Hansen J, Allotey P, Gyapong M, Sommerfeld J: Social research on neglected diseases of poverty: continuing and emerging themes. PLoS Negl Trop Dis. 2009, 3 (2): e332-10.1371/journal.pntd.0000332.
Ridley R: Applying science to the diseases of poverty. Bull World Health Organ. 2007, 85 (7): 509-510.
Allotey P, Reidpath DD, Ghalib H, Pagnoni F, Skelly WC: Efficacious, effective, and embedded interventions: implementation research in infectious disease control. BMC Pub health. 2008, 8: 343-10.1186/1471-2458-8-343.
Alsan MM, Westerhaus M, Herce M, Nakashima K, Farmer PE: Poverty, global health, and infectious disease: lessons from Haiti and Rwanda. Infect Dis Clinics of North America. 2011, 25 (3): 611-622. 10.1016/j.idc.2011.05.004. ix
Hotez PJ: Neglected infections of poverty among the indigenous peoples of the arctic. PLoS Negl Trop Dis. 2010, 4 (1): e606-10.1371/journal.pntd.0000606.
Birbeck GL, Wiysonge CS, Mills EJ, Frenk JJ, Zhou XN, Jha P: Global health: the importance of evidence-based medicine. BMC Med. 2013, 11: 223-
Huntington D: Health systems perspectives - infectious diseases of poverty. Infect Dis Poverty. 2012, 1 (1): 12-10.1186/2049-9957-1-12.
Amo-Adjei J: Views of health service providers on obstacles to tuberculosis control in Ghana. Infect Dis Poverty. 2013, 2 (1): 9-10.1186/2049-9957-2-9.
Zhou XN, Bergquist R, Tanner M: Elimination of tropical disease through surveillance and response. Infect Dis Poverty. 2013, 2 (1): 1-10.1186/2049-9957-2-1.
Collins C, Xu J, Tang S: Schistosomiasis control and the health system in P.R. China. Infect Dis Poverty. 2012, 1 (1): 8-10.1186/2049-9957-1-8.
Bergquist R, Whittaker M: Control of neglected tropical diseases in Asia Pacific: implications for health information priorities. Infect Dis Poverty. 2012, 1 (1): 3-10.1186/2049-9957-1-3.
Li XX, Chen JX, Wang LX, Tian LG, Zhang YP, Dong SP, Hu XG, Liu J, Wang FF, Wang Y: Intestinal Parasite Co-infection among Pulmonary Tuberculosis Cases without Human Immunodeficiency Virus Infection in a Rural County in China. Am J Trop Med Hyg. 2013, 2013: 13-0426.
Ukwaja KN, Alobu I, Abimbola S, Hopewell PC: Household catastrophic payments for tuberculosis care in Nigeria: incidence, determinants, and policy implications for universal health coverage. Infect Dis Poverty. 2013, 2 (1): 21-10.1186/2049-9957-2-21.
Tian LG, Wang TP, Lv S, Wang FF, Guo J, Yin XM, Cai YC, Dickey MK, Steinmann P, Chen JX: HIV and intestinal parasite co-infections among a Chinese population: an immunological profile. Infect Dis Poverty. 2013, 2 (1): 18-10.1186/2049-9957-2-18.
Mazigo HD, Nuwaha F, Wilson S, Kinung'hi SM, Morona D, Waihenya R, Heukelbach J, Dunne DW: Epidemiology and interactions of Human Immunodeficiency Virus - 1 and Schistosoma mansoni in sub-Saharan Africa. Infect Dis Poverty. 2013, 2 (1): 2-10.1186/2049-9957-2-2.
TDR: a time to live or die?. Lancet. 2012, 379 (9826): 1562-
World Health O: Research priorities for the environment, agriculture and infectious diseases of poverty. World Health Organ Tech Rep Ser. 2013, i-xiii (976): 1-125.
Malama S, Muma JB, Godfroid J: A review of tuberculosis at the wildlife-livestock-human interface in Zambia. Infect Dis Poverty. 2013, 2 (1): 13-10.1186/2049-9957-2-13.
Tang S, Ehiri J, Long Q: China's biggest, most neglected health challenge: Non-communicable diseases. Infect Dis Poverty. 2013, 2 (1): 7-10.1186/2049-9957-2-7.
Tambo E, Adedeji AA, Huang F, Chen JH, Zhou SS, Tang LH: Scaling up impact of malaria control programmes: a tale of events in Sub-Saharan Africa and People's Republic of China. Infect Dis Poverty. 2012, 1 (1): 7-10.1186/2049-9957-1-7.
Paudel M, Acharya B, Adhikari M: Social determinants that lead to poor knowledge about, and inappropriate precautionary practices towards, avian influenza among butchers in Kathmandu, Nepal. Infect Dis Poverty. 2013, 2 (1): 10-10.1186/2049-9957-2-10.
Ackumey MM, Gyapong M, Pappoe M, Maclean CK, Weiss MG: Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: Implications for disease control. Infect Dis Poverty. 2012, 1 (1): 6-10.1186/2049-9957-1-6.
Shi B, Xia S, Yang GJ, Zhou XN, Liu J: Inferring the potential risks of H7N9 infection by spatiotemporally characterizing bird migration and poultry distribution in eastern China. Infect Dis Poverty. 2013, 2 (1): 8-10.1186/2049-9957-2-8.
Dabo A, Bary B, Kouriba B, Sankare O, Doumbo O: Factors associated with coverage of praziquantel for schistosomiasis control in the community-direct intervention (CDI) approach in Mali (West Africa). Infect Dis Poverty. 2013, 2 (1): 11-10.1186/2049-9957-2-11.
Adhikari SR, Supakankunti S, Khan MM: Decision-making process of Kala Azar care: results from a qualitative study carried out in disease endemic areas of Nepal. Infect Dis Poverty. 2013, 2 (1): 14-10.1186/2049-9957-2-14.
Zhou XN: Prioritizing research for "One health - One world". Infect Dis Poverty. 2012, 1 (1): 1-10.1186/2049-9957-1-1.
Yin JH, Yang MN, Zhou SS, Wang Y, Feng J, Xia ZG: Changing Malaria Transmission and Implications in China towards National Malaria Elimination Programme between 2010 and 2012. PloS One. 2013, 8 (9): e74228-10.1371/journal.pone.0074228.
Xiao N, Yao JW, Ding W, Giraudoux P, Craig PS, Ito A: Priorities for research and control of cestode zoonoses in Asia. Infect Dis Poverty. 2013, 2 (1): 16-10.1186/2049-9957-2-16.
Wiwanitkit V, Shi B, Xia S, Yang GJ, Zhou XN, Liu J: Research priorities in modeling the transmission risks of H7N9 bird flu. Infect Dis Poverty. 2013, 2 (1): 17-10.1186/2049-9957-2-17.
Zheng Q, Vanderslott S, Jiang B, Xu LL, Liu CS, Huo LL, Duan LP, Wu NB, Li SZ, Xia ZG: Research gaps for three main tropical diseases in the People's Republic of China. Infect Dis Poverty. 2013, 2 (1): 15-10.1186/2049-9957-2-15.
Zinsstag J: Towards a science of rabies elimination. Infect Dis Poverty. 2013, 2 (1): 22-10.1186/2049-9957-2-22.
Qian MB, Chen YD, Yan F: Time to tackle clonorchiasis in China. Infect Dis Poverty. 2013, 2 (1): 4-10.1186/2049-9957-2-4.
Crisp N: Global health capacity and workforce development: turning the world upside down. Infect Dis Clinics of North America. 2011, 25 (2): 359-367. 10.1016/j.idc.2011.02.010.
Butler CD: Infectious disease emergence and global change: thinking systemically in a shrinking world. Infect Dis Poverty. 2012, 1 (1): 5-10.1186/2049-9957-1-5.
So AD, Ruiz-Esparza Q: Technology innovation for infectious diseases in the developing world. Infect Dis Poverty. 2012, 1 (1): 2-10.1186/2049-9957-1-2.
Reeder JC: TDR: a time to live. Lancet. 2012, 380 (9843): 729-730.
The authors declare that they have no competing interests.
SX, PA, DR, XNZ drafted the first version of the manuscript. SX, PY, HFS, XNZ perform the data analysis. SX, PA, DR, XNZ participated in the revisions. All authors read and approved the final manuscript.
Authors’ original submitted files for images
Below are the links to the authors’ original submitted files for images.
About this article
Cite this article
Xia, S., Allotey, P., Reidpath, D.D. et al. Combating infectious diseases of poverty: a year on. Infect Dis Poverty 2, 27 (2013). https://doi.org/10.1186/2049-9957-2-27