Skip to main content

Table 1 The distribution of genetic prion diseases in European and East Asians countries

From: Epidemiological characteristics of human prion diseases

Diseases Mutations Europeans [27] East Asians [10, 29, 3135] P-valuea
Total (n = 420) China (n = 62) Japan (n = 216) Korea (n = 15) Total (n = 293)
gCJD Insertion 39 2 3 0 5 P < 0.001
  N171S-129 V 1 0 0 0 0 n.s.
  D178N-129 V 16 0 1 0 1 P < 0.01
  V180I-129 M 1 1 89 5 95 P < 0.001
  T188A-129 M 3 0 0 0 0 n.s.
  T188K-129 M 0 16 0 0 16 P < 0.001
  E196K-129 M/V 5 1 0 0 1 n.s.
  E200K-129 M/V 175 9 37 3 49 P < 0.001
  V203I-129 M 5 1 2 2 5 n.s.
  R208H-129 M 2 2 1 0 3 n.s.
  V210I-129 M 69 0 0 0 0 P < 0.001
  E211Q-129 M 4 0 0 0 0 n.s.
  M232R-129 M 0 0 33 2 35 P < 0.001
GSS P102L-129 M 24 3 39 2 44 P < 0.001
  P105L-129 M 0 0 5 0 5 P < 0.05
  A117V-129 V 12 0 0 0 0 P < 0.01
FFI D178N-129 M 64 27 3 1 31 n.s.
  1. aThe differences of frequencies of PRNP mutations between Europeans and East Asians were measured by the Chi-square test or Fisher’s exact test. gCJD, genetic Creutzfeldz-Jakob diseases; GSS, Gerstmann-Sträussler-Scheinker syndrome; FFI, fatal familial insomnia; n.s., not significant