Epidemiological characteristics of human prion diseases

Table 1 The distribution of genetic prion diseases in European and East Asians countries

Diseases	Mutations	Europeans [27]	East Asians [10, 29, 31–35]				P-value^a
Diseases	Mutations	Total (n = 420)	China (n = 62)	Japan (n = 216)	Korea (n = 15)	Total (n = 293)	P-value^a
gCJD	Insertion	39	2	3	0	5	P < 0.001
	N171S-129 V	1	0	0	0	0	n.s.
	D178N-129 V	16	0	1	0	1	P < 0.01
	V180I-129 M	1	1	89	5	95	P < 0.001
	T188A-129 M	3	0	0	0	0	n.s.
	T188K-129 M	0	16	0	0	16	P < 0.001
	E196K-129 M/V	5	1	0	0	1	n.s.
	E200K-129 M/V	175	9	37	3	49	P < 0.001
	V203I-129 M	5	1	2	2	5	n.s.
	R208H-129 M	2	2	1	0	3	n.s.
	V210I-129 M	69	0	0	0	0	P < 0.001
	E211Q-129 M	4	0	0	0	0	n.s.
	M232R-129 M	0	0	33	2	35	P < 0.001
GSS	P102L-129 M	24	3	39	2	44	P < 0.001
	P105L-129 M	0	0	5	0	5	P < 0.05
	A117V-129 V	12	0	0	0	0	P < 0.01
FFI	D178N-129 M	64	27	3	1	31	n.s.

^aThe differences of frequencies of PRNP mutations between Europeans and East Asians were measured by the Chi-square test or Fisher’s exact test. gCJD, genetic Creutzfeldz-Jakob diseases; GSS, Gerstmann-Sträussler-Scheinker syndrome; FFI, fatal familial insomnia; n.s., not significant

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