- Research Article
- Open Access
Determinants of treatment completion among rural smear positive pulmonary tuberculosis patients: a cross-sectional survey conducted in south-western Uganda
Infectious Diseases of Poverty volume 6, Article number: 104 (2017)
Treatment completion among tuberculosis patients remains low across various regions of Uganda, despite implementation of directly observed treatment short course. This study evaluated the determinants of treatment completion in a rural health sub-district of south western Uganda.
In April 2012, health facility records were reviewed to identify tuberculosis patients who had been initiated on treatment between June 2008 and May 2011, in Rwampara Health Sub-District, south-western Uganda. Out of the 162 patients identified, 128 (79%) were traced and subsequently interviewed during a survey conducted in June 2012. Eleven (6.8%) of the 162 patients died, while 23 (14.2%) could not be traced. A review of records showed that 17 of those that could not be traced completed treatment while the other six did not have definitive records.
Treatment completion among the 128 patients interviewed was 89.8%. Pre-treatment counselling (aOR = 24.3, 95% CI: 1.4–26.6, P = 0.03), counselling at the time of submission of sputum during follow up (aOR = 6.8, 95% CI: 1.4–33.7, P = 0.02), and refill of drugs on the exact appointment date (aOR = 13.4, 95% CI: 1.9–93.0, P = 0.01), were independently associated with treatment completion.
The level of treatment completion was higher than the national average, with service- related determinants identified as being critical for ensuring treatment completion. These data provide further evidence for the need to provide ongoing counselling support to tuberculosis patients. Enhancing the opportunities for counselling of tuberculosis patients should therefore be rigorously promoted as an approach to increase treatment completion in rural settings.
Please see Additional file 1 for translations of the abstract into the five official working languages of the United Nations.
The tuberculosis (TB) burden and infection rates have remained high despite internationally recommended strategies to contain the disease. In 2014, an estimated 9.6 million new TB cases were reported worldwide: 5.4 million among men, 3.2 million among women and 1.0 million among children . The African region accounts for 28% of the reported cases .
The currently recommended treatment for new cases of drug-susceptible TB is a 6-month regimen of four first-line drugs: isoniazid, rifampicin, ethambutol and pyrazinamide . Although TB is curable the emergence of drug-resistant strains of the causative Mycobacterium genus is a global threat to its control . Therefore, failure to adhere to the prescribed regimen measured as “treatment completion”, is cited as one of the greatest problems facing the current control strategies . “Treatment completion” together with “treatment success” are some of the indicators to measure performance of national TB control programs [1, 5]. An earlier study suggested that increasing patient-centeredness of interactions between providers and clients promotes TB treatment adherence , yet as a component of pillar 1 of the End TB Strategy, the World Health Organization (WHO) recommends the need for all TB patients to receive educational, emotional, and economic support to enable them to complete treatment [6, 7]. A study in South Africa reported that adjustments in access to the health-care system enhanced TB treatment completion . The WHO has set treatment success target of ≥ 90% by the year 2025 .
Uganda remains a high burden country, with a prevalence rate of 161 TB cases per 100 000 people [9,10,11]. Nationally, Uganda’s TB and Leprosy Prevention and Control Program was not able to achieve targets for indicators related to treatment success and cure rates in the year 2014/15. This has been attributed to low adherence to treatment as evidenced by the low achievement (68% of TB patients) of directly observed treatment, short course (DOTS) . Other challenges faced by the Uganda’s TB program relate to inadequate systems for TB case detection, adherence monitoring and testing relapses for drug sensitivity .
The Rwampara Health Sub-District (HSD) is located in the Mbarara District of south western Uganda. It has a population of 152 600, which is served by five TB treatment centers (including four health centers at sub-county level and one at county level). In 2011, the HSD reported a treatment success of 55% . This was below that reported at the national level which ranged from 65 to 73% among new cases, from 2009 to 2011 [9, 14]. In response to this, the present study evaluated the determinants of TB treatment completion in Rwampara HSD for the period from 2009 to 2011.
Study setting and sample size
In April 2012, the study team reviewed health facility records of all TB patients who had been initiated on treatment between June 2008 and May 2011, in Rwampara HSD. A survey was then conducted among the patients identified from the records in June 2012.
The study participants were selected from among those receiving TB treatment in the HSD regardless of the TB management strategy deployed, i.e. community-based (CB) versus health facility-based (HF) DOTS. The participants included both new and retreatment smear positive pulmonary TB patients. Tuberculosis patient registers were obtained from the five treatment centres and the study participants were identified. The treatment centre registers had a total of 162 patients who had started treatment between June 2008 and May 2011, and were expected to have completed treatment by the commencement of the survey in 2012. All the identified patients (162) were included in the survey as potential participants. The participants were traced in the community with the guidance of community health workers and village leaders who acted as field guides.
Questionnaire design and administration
A standardized interviewer administered questionnaire was used during the patient survey to collect information on socio-demographic data; knowledge on TB treatment; treatment practices by patients, and community and health workers; adherence to TB medication; and health facility-based factors such as drug availability, health worker availability, and waiting time. Medical records were reviewed for information on the demographics, counselling, HIV testing, cadre of health workers available to treat patients, treatment strategy, medical commodities available, and treatment completion pertaining to patients in order to determine whether they were transferred, could not be traced, died, or had completed treatment successfully.
The questionnaire was pretested at a treatment centre on patients who were on treatment in order to identify any problems associated with its interpretation. Then findings from the pre-test were used to improve the wording of the questions, their sequence, as well as the length of the questionnaire.
Definitions of variables
The variables were defined as follows:
Treatment completion was defined as “a TB patient who completed treatment without evidence of failure but there was no record to show that sputum smear or culture results in the last month of treatment and on at least one previous occasion were negative, either because they were not done or because results were not available” [4, 5]. Patients were classified as having completed treatment if they had swallowed their medication for the prescribed period.
Adherent patients were those who swallowed the drugs as prescribed daily for 6 months consistently (the recommended period for TB regimen), while non-adherent were patients who had interruptions in taking TB medication during the 6 month period. Patients were classified as adherent if they swallowed 90% of the total medication they were given.
Access to the health unit providing TB services was defined as living within a physical distance of five kilometres (≤5 km) from a health facility.
Waiting time was measured as the period a patient spends at a treatment centre from the time of arrival to when a TB-related service is provided. Waiting time was measured in hours and compared against the Government of Uganda recommendation of 1 h [15, 16].
The analysis was done using STATA version 12 software . Two-sided chi-square tests for association were computed to detect differences between categorical variables such as sex, alcohol consumption, drug side effects, presence of treatment supporter, family support, drug availability, and waiting time. The means of continuous variables were compared using t-tests. The strength of association was interpreted based on a sliding scale of P-values.
In order to investigate the relationship between the outcome variable (treatment completion) and other variables, logistic regression models were run. The model building strategy was not only limited to significant variables from the bivariate analysis, but also included independent variables that were considered to have a clinical and social significance for the outcome [18, 19]. These independent variables were: pre-treatment counselling, health worker availability, counselling at the time of submission of follow-up sputum, timely medicine refills, adherence to treatment, waiting time at health facility, and whether the patient had been tested for HIV. The demographic variables were not included in the models because the two groups of patients (completed and did not complete treatment) were similar with regard to these characteristics.
The evaluation of the determinants of treatment completion was based on 128 participants due to missing information on several variables for those who had either died or been lost to follow-up.
Tracing of study participants
Out of the 162 patients, 128 (79%) were traced and subsequently interviewed. Eleven (6.8%) of the 162 patients died while 23 (14.2%) could not be traced. A flow diagram of the participants is shown in Fig. 1.
A review of records showed that 17 of those who were not traced completed treatment, while the other six did not have definitive records.
Patient sociodemographic characteristics
A record review of those alive showed that 115 (89.8%) had completed treatment. The sociodemographic characteristics of these patients are shown in Table 1.
The majority of the patients were: female (71.3%), ever married (88.7%), and attained a level of formal education; the minimum level in this case was primary education (77.4%). Eighty-eight percent (88%) of the participants had children. The mean age in years was 43.3 for participants who completed treatment and 41.7 years for those who did not complete treatment. Their age ranges in years were 18–84 and 26–74, respectively. The two groups of study participants (completed and did not complete treatment) did not differ on all the characteristics reported in Table 1.
Association between patient medical and other characteristics, and treatment completion
Table 2 compares the medical and other characteristics of patients, by treatment completion.
Patients who had never consumed alcohol (odds ratio, OR = 5.8, 95% confidence interval, CI: 1.7–20.2) were more likely to complete TB treatment. A larger proportion (54%) of the patients who did not complete treatment experienced side effects, however, this result was not statistically significant (OR = 0.4, 95% CI: 0.1–1.2).
Association between service-related factors and treatment completion
Information on service-related factors for the patients was obtained from the records of the treatment centres. A comparison of these factors by treatment completion is shown in Table 3.
Patients who were counselled before initiation of TB therapy were 12 times more likely to complete their treatment (OR = 12.3, 95% CI: 2.6–57.7). Counselling at the time of submission of sputum during follow-up (OR = 5.8, 95% CI: 1.7–19.2), availability of health workers at treatment centre (OR = 6.8, 95% CI: 1.0–45.1), and drug collection on exact appointment date, also known as timely refill (OR = 9.9, 95% CI: 2.1–47.0) were all significantly associated with treatment completion. Again, there was a very weak positive correlation between “pre-treatment counselling” and “counselling at the time of submission” of follow-up sputum samples during the course of the treatment (correlation coefficient “r” 0.143). However treatment strategy (CB-DOTS or HF-DOTs) and treatment category (new or retreatment case) were not significantly associated with treatment completion.
Independent determinants of treatment completion
The results from the logistic regression analysis are presented in Table 4.
Pre-treatment counselling (adjusted OR = 24.3, 95% CI: 1.4–426.6, P = 0.03), counselling at the time of submission of sputum follow-up (aOR = 6.8, 95% CI: 1.4–33.7, P = 0.02), and refill of drugs on exact appointment date (aOR = 13.4 95% CI: 1.9–93.0, P = 0.01) were all found to be independently associated with treatment completion.
The findings show that the major determinants for treatment completion in this rural context were pre-treatment counselling, counselling at the time of the follow-up sputum submission visit, and timely drug refills. Consistent with studies conducted elsewhere counselling of TB patients impacts on treatment completion and better communication improves adherence [20,21,22]. A study conducted in Uganda reported that patients who are counselled more frequently tend to take their medication more consistently . In the current study, the variation in the quality of counselling might have impacted the results. However, information on the quality of counselling was not collected and is an area for further investigation.
Good communication leads to understanding and therefore promotes observance of treatment requirements such as timely drug refills, resulting in improved treatment completion and cure . On the other hand, the effects of non-dialogue counselling have been linked to non-adherence among TB patients . Well-informed patients understand the importance of un-interrupted medication taking and patient knowledge about the dangers of not adhering to treatment is enhanced.
The treatment completion rate reported here is high when compared to the district and national rates at the time of the study [9, 13]. The lower district figures could be due to the reporting system failing to capture patient information in a number of cases. Patients tend to shift from one treatment centre to another without notifying the original treatment centre. This happens when drugs become unavailable at a given treatment centre and results in patients seeking medication at another centre. The original treatment centre then records these patients as defaulters and this is reflected in the district figures. Therefore, timely drug refill is a function of the health system factors (health workers’ knowledge and skills in managing TB patients, availability of drugs, etc) and the patient’s own responsibility of monitoring their personal drug stocks. In some studies, treatment supporters (who are often relatives) who monitor drug stocks and patients swallowing prescribed medicines have been used to counteract treatment interruption . A study conducted in Nigeria reported that the attitude of health workers was associated with TB treatment interruption. It is suggested that the unfriendly attitude of health care providers may make patients feel threatened and unwelcomed leading to treatment interruption . The attitude of health workers is also likely to affect TB patient participation in on-going counselling and therefore subsequently influence treatment completion.
In contrast to the findings of a review of studies conducted in Uganda and elsewhere, sex, education, distance to treatment centre, and treatment regimen, were not found to be associated with treatment completion [24, 27,28,29,30]. However, consistent with other study findings, TB treatment strategy was not associated with treatment completion . Some patients choose the HF-DOTS strategy because they either live close or have transport to the health facility and trust health workers with the responsibility of their treatment. This group of patients is also likely to complete treatment as observed among patients using CB-DOTS, resulting in no significant difference between the two strategies.
Health worker availability and mean duration on treatment were not independently associated with treatment completion. This can mainly be attributed to the use of CB-DOTS treatment strategy by the majority of patients in this rural setting.
Although the study was confined to one HSD this study area is typical of other rural setting in terms of health infrastructure in Uganda. The study findings are therefore comparable across similar settings. We also note that this was a cross-sectional study and therefore we cannot define the temporal relationship between the independent variables and outcome. The direction of causality can therefore only be regarded as suggestive. The data collected on a number of independent variables were based on self-reports that are likely to be subject to social desirability bias. As a result there is a limit to which such responses can be considered accurate by foreknowledge of what, in the view of the respondent, would be a suitable response. However, the current findings do carry implications for health service managers, decision-makers, and health care providers in their consideration of the designing and implementing TB services.
The findings demonstrate a high level of treatment completion among rural TB patients in the study setting, with service-related determinants identified as critical for ensuring treatment completion. These data provide further evidence for the need to provide ongoing counselling support to TB patients. Enhancing the opportunities for counselling of TB patients should therefore be rigorously promoted as an approach to increase treatment completion in rural settings.
In these contexts ongoing counselling builds the health provider patient relationship that is likely to result in treatment compliance and subsequently completion. However, for this to be realized, it is critical for TB programs in Uganda and elsewhere to ensure that timely refills are actualized in rural health facilities.
- aOR :
Adjusted odds Ratio
- CI :
International Clinical, Operational and Health Services Research
Health facility-based DOTS
Health sub district
Joint Clinical Research Centre
World Health Organization
World Health Organization. Global Tuberculosis Report 2015. Geneva: World Health Organization; 2015.
World Health Organization. Systematic screening for active tuberculosis: an operational guide. Geneva: World Health Organization; 2015.
Tesfahuneygn G, Medhin G, Legesse M. Adherence to Anti-tuberculosis treatment and treatment outcomes among tuberculosis patients in Alamata District, northeast Ethiopia. BMC Res Notes. 2015;8:503.
Caylà JA, et al. Current status of treatment completion and fatality among tuberculosis patients in Spain. Int J Tuberc Lung Dis. 2004;8(4):458–64.
World Health Organization. Definitions and reporting framework for tuberculosis – 2013 revision (updated December 2014). Geneva: World Health Organization; 2014.
TB CARE I. International Standards for Tuberculosis Care. The Hague: TB CARE I; 2014.
World Health Organization. Implementing the End TB Strategy: The Essentials. Geneva: World Health Organization; 2015.
Culqui DR, et al. Factors associated with the non-completion of conventional anti-tuberculosis treatment in Peru. Arch Bronconeumol. 2012;48(5):150–5.
World Health Organization. TB Country Profile. Geneva: World Health Organization; 2015.
Anyama N, et al. The challenge of re-treatment pulmonary tuberculosis at two teaching and referral hospitals in Uganda. Afr Health Sci. 2007;7(3):136–42.
Ministry of Health. Health Sector Development Plan 2015/16 - 2019/20. Kampala: Ministry of Health; 2015.
Ministry of Health. Annual Health Sector Peformance Report 2014/15. Kampala: Ministry of Health; 2015.
Mbarara District Local Government. HMIS Report 2011. Mbarara: Mbarara District Health Office; 2011. M.D.H. Office, Editor.
Ministry of Health. Annual Health Sector Performance Report 2013/2014. Kampala: Ministry of Health; 2014.
Ministry of Health. The Second National Health Policy: Promoting People’s Health to Enhance Socio-economic Development. Kampala: Ministry of Health; 2010.
Health, M.o. Health Sector Strategic and Investment Plan. Kampala: Ministry Of Healthj; 2010.
StataCorp. STATA Statistics/Data Analysis, 1985-2011, StataCorp: College Station.
Annals of Internal Medicine. Information for Authors - General Statistical Guidance. 2016 [cited 2016 30/09/2016]; Available from: http://annals.org/SS/AuthorInformationStatisticsOnly.aspx.
Victoria CG, et al. The role of conceptual frameworks in epidemiological analysis: a hierarchical approach. Int J Epidemiol. 1997;26(1):224–7.
Liefooghe R, et al. A randomised trial of the impact of counselling on treatment adherence of tuberculosis patients in Sialkot, Pakistan. Int J Tuberc Lung Dis. 1999;3(12):1073–80.
Mishra P, et al. Adherence is associated with the quality of professional-patient interaction in Directly Observed Treatment Short-course, DOTS. Patient Educ Couns. 2006;63(1-2):29–37.
Mulenga C, et al. Management of pulmonary tuberculosis patients in an urban setting in Zambia: a patient’s perspective. BMC Public Health. 2010;10:756.
Amuha MG, et al. Non-adherence to anti-TB drugs among TB/HIV co-infected patients in Mbarara Hospital Uganda: Prevalence and associated factors. Afr Health Sci. 2009;9(S1):8–15.
Castelnuovo B. A review of compliance to anti tuberculosis treatment and risk factors for defaulting treatment in Sub Saharan Africa. Afr Health Sci. 2010;10(4):320–4.
Adejumo OA, et al. Factors affecting treatment interruption among TB patients in Lagos Nigeria: is there any need for treatment supporters? Int J Clin Med. 2016;7(06):389.
Ibrahim LM, et al. Factors associated with interruption of treatment among Pulmonary Tuberculosis patients in Plateau State, Nigeria 2011. Pan Afr Med J. 2014;17(1).
Wilkinson D, Davies GR, Connolly C. Directly observed therapy for tuberculosis in Rural South Africa, 1991 through 1994. Am J Public Health. 1996;86(8):1094–7.
Peltzer K, Pengpid S. Predictors of non-adherence to anti-tuberculosis medication in tuberculosis patients in Thailand. J Hum Ecol. 2015;52(1,2):26–31.
Anuwatnonthakate A, et al. Directly observed therapy and improved tuberculosis treatment outcomes in Thailand. PLoS One. 2008;3(8):e3089. doi:10.1371/journal.pone.0003089.
Nuwaha F. Factors influencing completion of treatment among tuberculosis patients in Mbarara District, Uganda. East Afr Med J. 1997;74(11):690–3.
Wang J, Shen H. Direct observation and completion of treatment of tuberculosis in rural areas of China. Scand J Public Health. 2009;37(3):304–9.
The study team acknowledges the support and contributions of; the JCRC’s COHRE Program, the staff of the TB treatment centres and community health workers in Rwampara HSD, Mbarara District Health Office and the survey team members.
The research was financially supported by the Joint Clinical Research Centre’s (JCRC) International Clinical, Operational and Health Services Research (COHRE) program in Uganda. The JCRC’s COHRE program did not participate in the design of the study, data collection, analysis, and interpretation of the data or the writing of the paper.
Availability of data and materials
All data supporting our findings are contained in the paper. There are no restrictions to data sources, however, details of the full data may be accessed through Prof. Edgar M Mulogo (corresponding author), Department of Community Health, Mbarara University of Science and Technology, PO Box 1410, Mbarara, Uganda, email: email@example.com, Tel: +256772433508, Skype address; edgar.mulogo1.
CN was involved in the conception and design of the study, its implementation, analysis of the data, and interpretation of the findings. EMM participated in the conception and design of the study, analysis of the data and drafting of the paper. FB participated in the interpretation of the findings, while VB participated in the drafting of the paper. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Ethics approval and consent to participate
Ethical approval for this study was sought and obtained from the Research Ethics Committee at Mbarara University of Science and Technology. Written informed consent was also obtained from the individual subjects.
Additional file 1:
Multilingual abstracts in the five official working languages of the United Nations. (PDF 585 kb)
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
About this article
Cite this article
Mulogo, E.M., Nahabwe, C., Bagenda, F. et al. Determinants of treatment completion among rural smear positive pulmonary tuberculosis patients: a cross-sectional survey conducted in south-western Uganda. Infect Dis Poverty 6, 104 (2017). https://doi.org/10.1186/s40249-017-0313-3
- Treatment completion
- Rural Uganda