Skip to main content
  • Scoping Review
  • Open access
  • Published:

Burden of onchocerciasis-associated epilepsy: first estimates and research priorities



Since the 1990s, evidence has accumulated of an increased prevalence of epilepsy in onchocerciasis-endemic areas in Africa as compared to onchocerciasis-free areas. Although the causal relationship between onchocerciasis and epilepsy has yet to be proven, there is likely an association. Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy (OAE), provide them, detail how such estimates should be refined, and discuss the socioeconomic impact of OAE, including a cost-estimate for anti-epileptic drugs.

Main body

Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis- endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services. Epilepsy not only massively impacts the health of those affected, but it also carries a high socioeconomic burden for the households and communities involved. We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases. We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability (YLD) and estimate the cost of treatment. We estimate that in 2015 roughly 117 000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control (APOC) mandate where OAE has ever been reported or suspected, and another 264 000 persons in onchocerciasis-endemic areas where OAE has never been investigated before. The total number of YLDs due to OAE was 39 300 and 88 700 in these areas respectively, based on a weighted mean disability weight of 0.336. The burden of OAE is approximately 13% of the total YLDs attributable to onchocerciasis and 10% of total YLDs attributable to epilepsy. We estimated that by 2015 the total costs of treatment with anti-epileptic drug for OAE cases would have been a minimum of 12.4 million US$.


These estimates suggest a considerable health, social and economic burden of OAE in Africa. The treatment and care for people with epilepsy, especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources.

Multilingual abstracts

Please see Additional file 1 for translations of the abstract into the six official working languages of the United Nations.


Onchocerciasis, or “river blindness”, is targeted for elimination, using preventive chemotherapy through mass drug administration (MDA) with ivermectin as the primary intervention strategy [1]. Onchocerciasis is transmitted by the bite of infected blackflies that breed in fast-flowing rivers. It causes stigmatising skin disease and vision loss, the latter eventually leading to blindness, nearly all cases occurring in sub-Saharan Africa (SSA). Since the 1990s, high prevalence of epilepsy in onchocerciasis highly-endemic areas has increasingly been reported, especially in localised foci across Africa [2,3,4,5,6,7,8].

In general, the prevalence of epilepsy in sub-Saharan Africa is higher as compared to Asia, Europe and North America [9]; the mean prevalence in Africa is 26% higher than the global mean [10]. Epilepsy is more common in Africa due to several factors, including socioeconomic deprivations, limited access to high quality and affordable healthcare facilities, particularly in rural areas [10]. The Global Burden of Disease (GBD) study estimated for the year 2015 a total of 2.66 million disability-adjusted life years (DALYs) (95% CI: 2.15–3.28) attributed to epilepsy, and 0.99 million DALYs (95% CI: 0.45–1.72) attributable to onchocerciasis in SSA [11]. Various studies have estimated the number of people with active epilepsy in SSA with numbers ranging from 2.5 million to 4.5 million [10,11,12]. Only a fraction of these epilepsy cases may potentially be attributed to onchocerciasis-associated epilepsy (OAE) [13]. An early, crude assessment of the burden of OAE in SSA estimated approximately 100 000 cases (2011 data) [14]. Given the negative consequences of OAE, this number should be refined with more granular data and more advanced methods since these numbers were estimated as a proportion of a predicted number of Onchocerca volvulus-infected people in the absence of MDA. OAE-affected individuals are subject to high economic costs, stigmatisation, discrimination [15] and premature mortality [16] if left untreated.

In this review, we discuss the current evidence of an association between onchocerciasis and epilepsy, and provide the first estimates of OAE burden in terms of expected number of cases, years of life lived with disability (YLDs), and socioeconomic consequences for onchocerciasis-endemic areas previously under the African Programme for Onchocerciasis Control (APOC) mandate. Furthermore, we suggest research priorities to assist in building consensus on the prioritisation of the OAE research agenda and the diligence of human and financial resources required to prevent new OAE cases.

Are onchocerciasis and epilepsy associated?

Many well-known, non-infectious causes of epilepsy may contribute to the burden of epilepsy in onchocerciasis-endemic areas, including perinatal trauma, genetic factors, environmental/toxic factors or nutritional deficiencies that occur early in life [9]. Some parasitic infections are known to be associated with epilepsy, including neurocysticercosis (NCC) (due to Taenia solium), toxoplasmosis (due to Toxoplasma gondii), and malaria, among others [9]. For example, T. solium in particular is endemic in many African countries where widespread free-roaming of pigs occurs and where pork is consumed [17], and it is estimated that around 30% of the acquired epilepsy in T. solium-endemic areas of developing countries is caused by NCC [18]. It is likely that NCC plays an important role in SSA, although there is little knowledge on how widespread the distribution of NCC in SSA is [17]. The role of other parasitic infections in causing epilepsy, including O. volvulus infection, has been much less established. Although several cross-sectional and case-control studies show an association between onchocerciasis and epilepsy [3, 4, 19, 20], it is challenging to interpret such studies and demonstrate causality in this association due to co-infection with multiple other parasites (e.g. Plasmodium falciparum, T. gondii, T. solium [21]) and other confounding factors.

On the population-level, there is evidence of an association between epilepsy and onchocerciasis. A meta-analysis by Pion et al. [4] found an association between onchocerciasis and epilepsy using population-based surveys; on average there was a 0.4% increase in epilepsy for each 10% increase in onchocerciasis prevalence. This association is based on studies from eight communities in seven African countries. In only two areas (in Cameroon) NCC was reported to be endemic [2, 4, 22], but additional information from one of these areas show that a maximum of four possible or borderline T. solium-infected individuals were found out of 53 people with epilepsy [5]. It should be noted, however, that detection of NCC could be missed as diagnosis on the basis of serologic tests alone would be incomplete due to low sensitivity or specificity [23, 24]. Another review performed a restricted analysis on case-control studies that controlled for gender, age and place of residence [3]. This review by Kaiser et al. found a weak positive association between skin snip positivity and epilepsy (pooled OR = 1.29; 95% CI: 0.93–1.79, P = 0.139). Additionally, it found that quantitative measures of infection intensity in individuals (i.e. mean microfilariae (mf), number of palpated nodules) was significantly higher in people with epilepsy (PWE) than in people without epilepsy (PWOE). In addition, preliminary results of a recent prospective study performed in the Mbam valley of Cameroon, looking at the incidence of epilepsy in O. volvulus-infected children at baseline in 1991–1993 with a follow-up in 2017, suggest that the incidence rate ratio of epilepsy was significantly higher in children with very high initial mf intensities/skin snips [25]. These results suggest a dose-response relationship wherein the risk of developing epilepsy in onchocerciasis patients is higher with increasing O. volvulus mf density, supporting the hypothesis that a proportion of epilepsy cases in an onchocerciasis-endemic area are to be caused by onchocerciasis. The effect of ivermectin on preventing new OAE cases or on reducing the seizure frequency of prevalent epilepsy cases is to be further investigated, although recent studies suggest that ivermectin has a positive effect on epilepsy incidence [26, 27]. It is also reported that ivermectin can reduce severity and frequency of epileptic seizures [28], but it is yet unclear if this is due to the anticonvulsant properties of ivermectin or due to flaws in the methodology of the respective study. More studies are currently underway to assess the impact of MDA on OAE [29].

There is still no definitive pathophysiologic explanation for the link between onchocerciasis and epilepsy. Studies in children with nodding syndrome (a childhood epilepsy disorder described in O. volvulus-endemic areas) suggest that antibodies to a protein (leiomodin-1) present in neurons may cross-react with a similar protein that is present in the parasite O. volvulus [30]. Further research herein would be strongly recommended.

The challenges of defining an onchocerciasis-associated epilepsy case

In spite of the population-level association between onchocerciasis and epilepsy, it is difficult to attribute individual epilepsy cases to onchocerciasis. Epilepsy is a condition characterised by recurrent (two or more) afebrile epileptic seizures at least 24 h apart, unprovoked by any immediate identified cause, thus not due to an acute intracranial or extracranial condition [31]. Individuals with one unprovoked seizure but with a > 60% recurrence risk of epileptic seizures due to an enduring epileptogenic abnormality are also considered to be epileptic [31]. Whether an epileptic seizure associated with O. volvulus infection also has a > 60% chance of recurrence is unknown and may depend on the mf load and whether the person has been treated with ivermectin. Nonetheless, the chances of epilepsy being caused by onchocerciasis are more likely in areas with high onchocerciasis transmission rates, evidence of O. volvulus infection, and onset of epilepsy at young age (~ 5–18 years old) [32]. Exclusion of other causes leading to epilepsy, such as NCC, is often not optimal in rural settings due to the unavailability of neuroimaging and requires the establishment of an epilepsy-triaging system [33]. Without the ability to exclude all other causes of epilepsy, it is impossible to confirm a case as OAE. Proper differentiation between causes of epilepsy in remote areas across SSA, keeping the limited access to advanced technological instruments in mind, is still an area that should receive further attention. Studies investigating the prevalence of OAE should therefore always attempt to include a thorough medical/neurological history and examination as well as diagnosis of various parasitic infections, including NCC, malaria, and toxoplasmosis, among others.

Quantifying the number of OAE cases in sub-Saharan Africa

In order to estimate the potential burden of OAE in Africa, we first identified areas where OAE has been reported or suspected (independent on whether the study found a significant association between onchocerciasis and epilepsy). We identified 19 areas in nine countries across SSA; Uganda [5, 26, 34, 35], Tanzania [36, 37], Cameroon [2], Nigeria [19], Central African Republic [20], Burundi [22], Benin [38], the Democratic Republic of Congo [39], and South Sudan [40]. Little knowledge is available from countries previously under the Onchocerciasis Control Programme (OCP)-mandate, but we expect negligible levels of probable OAE cases due to the long duration of vector control and MDA (OCP: 1974–2002), including in Benin [38]. We therefore focussed on areas previously under the APOC-mandate (“APOC-areas/countries”). For each APOC-area, population density data for 1995 was obtained using the APOC census (for more information, please be referred to the note of Additional file 2).

We first estimated the number of prevalent OAE cases prior to initiation of MDA with ivermectin (gradually introduced in the region since 1995, with exception of Kaduna, Nigeria (1991)). This was done by linking a previously published functional relationship between the pre-control community-level prevalence of infection and epilepsy [4] (corrected for background prevalence of epilepsy in settings with zero infection prevalence) to published estimates of the pre-control epidemiologically mapped distribution of infection prevalence in 20 APOC countries [41]. Details of the approach and the underlying assumptions are described in Table 1.

Table 1 Methods for calculating onchocerciasis-associated epilepsy (OAE) cases in the African Programme for Onchocerciasis Control (APOC) countries in 1995 (pre-control) and in 2015
Fig. 1
figure 1

Used published relationships and onchocerciasis map to calculate the pre-control prevalence of onchocerciasis-associated epilepsy. a Community-level all-cause epilepsy prevalence versus corrected onchocerciasis microfilariae prevalence, as published by Pion et al. [4]. b Map of the estimated pre-control prevalence of palpable nodules in the 20 African Programme for Onchocerciasis Control countries, as published by Zouré et al. [41]. c Predicted skin mf prevalence in the general population, given observed nodule prevalence in adult males, as published by Coffeng et al. [69]. Permission for publication of all figures was granted from the journals and authors

In the 18 remaining APOC-areas where OAE was reported or suspected, the total population size in 1995 was 9.2 million people (Table 2). All these 18 areas received treatment with MDA, starting between 1999 and 2012. We predict that the number of OAE cases in those areas was approximately 113 000 (95% CI: 53000–371 000), with an overall prevalence of 1.23% of OAE. If we would assume that OAE has a wider geographical distribution among other APOC-areas than those 18 areas, we would expect another 362 000 (95% CI: 185000–1 085 000) OAE cases in 1995 (total population size of 81.1 million among all other APOC-areas). We further estimated that approximately 61.5% of all OAE cases were located in onchocerciasis hyperendemic areas (nodule prevalence in adult males ≥40%), 28.7% in mesoendemic areas (20–40% nodule prevalence), and 9.8% in hypoendemic areas (< 20% nodule prevalence).

Table 2 Estimated number of onchocerciasis-associated epilepsy cases with 95% confidence intervals in the African Programme for Onchocerciasis Control-areas for two time periods

To estimate the number of OAE cases by 2015, we assumed that the number of prevalent cases increased over time due to population growth and that OAE prevalence declined during control of onchocerciasis only due to lower incidence for areas with MDA and excess mortality (i.e. assuming no direct effect of ivermectin on curing epilepsy, hence prevalent OAE cases). We predict that in 2015, there were approximately 117 000 (95% CI: 50 000–441 000) prevalent OAE cases, with an overall OAE prevalence of 0.74% (Table 2). If we assume that OAE is also present in onchocerciasis-endemic areas previously under the APOC mandate and where OAE has not (yet) been investigated, we predict an additional 264 000 (95% CI: 109 000–1 195 000) cases in 2015.

Of course, there are some limitations in the data and mathematical functions on which this analysis is based. Firstly, the model uses an infection prevalence map [41] based on the Rapid Epidemiological Mapping of Onchocerciasis (REMO) surveys. The REMO surveys have their own inherent challenges, including the use of the less sensitive palpation of nodules as compared to skin snipping. Secondly, the logistic functional relationship for prediction of OAE prevalence by onchocerciasis infection, as reported by Pion et al., includes the at that time available literature for which various corrections needed to be made in order to account for history of treatment and the various diagnostic methods used [4]. These are the best available data to estimate – for now - most accurately the number of OAE cases in APOC-countries. In addition, we applied a more realistic background all-cause epilepsy such as reported by the GBD for SSA (0.36%) rather than the reported background all-cause prevalence epilepsy by Pion et al. (0.17%).

Quantifying the disease burden: Years of life lived with disability

DALYs are a metric used to quantify the health loss attributable to a disease. They are calculated as the sum of years of life lost (YLLs) due to premature death from a disease and YLDs due to that disease, making DALYs a useful measure for policy purposes because they enable comparison of the importance of diseases. YLDs are calculated by multiplying the number of years lived with a certain disease manifestation with corresponding disability weights. The methods for the calculation of disability weights have been described in detail elsewhere [42, 43].

The GBD study assigned disability weights to more than 300 disorders and diseases, including epilepsy. The disability weight for severe epilepsy is one of the highest with a value of 0.552 (95% CI: 0.375–0.710). Other disability weights assigned to epilepsy health states vary in their application by seizure frequency and treatment status. The lowest disability weight is assigned to treatment-controlled, seizure-free epileptics with a value of 0.049 (95% CI: 0.031–0.072) (Table 3).

Table 3 Different sequela of epilepsy that could be applied to onchocerciasis-associated epilepsy (adapted from [72])

In order to assign disability weights and calculate DALYs attributable to OAE, certain pieces of information are needed:

  1. 1.

    The number of deaths attributable to OAE and the age at death;

  2. 2.

    The frequency of occurrence and severity of seizures (for choosing an applicable health state), and the proportion of patients in each of these health states;

  3. 3.

    The proportion of patients with controlled epilepsy, receiving treatment with any anti-epileptic drug (AED).

Unfortunately, this information is not widely reported in literature. A study in an area of Cameroon highly-endemic for onchocerciasis found that 47% of epilepsy cases in the area experienced at least one seizure in the 6 months prior to the study date while 16% were seizure-free with consistent therapy. At epilepsy onset, 37% had experienced daily seizures [44] (Table 4). DALY calculation for OAE is currently difficult due to the lack of information on the age-distribution of OAE deaths required for calculating YLLs (estimated as the sum difference between age at death and life expectancy at death). However, YLDs can be estimated as the product of the number of prevalent OAE cases and the disability weight for OAE. If the assertions around the epidemiological relationship as published by Pion et al. [4] are representative for the distribution of OAE in all countries previously under the APOC mandate, we estimate that in 2015 there were approximately 39 300 YLDs attributable to OAE in the areas where OAE has been reported or suspected and potentially 88 700 YLDs attributable to OAE in other areas where OAE has not been reported up to now. Calculations can be seen in Table 5.

Table 4 Frequency of different health states (indicating different severity levels) of epilepsy in an onchocerciasis hyperendemic area, associated disability weights for each health state (GBD), and calculation of the weighted mean disability weight across health states (weighted for the proportion of cases in each health state, based on Prischich et al. 2008 [44])
Table 5 Methods for calculating YLDs attributable to onchocerciasis-associated epilepsy (OAE)

There are some important limitations to these YLD estimates. First of all, one study is likely not representative of all epilepsy cases in Africa. We have therefore performed an additional sensitivity analysis to assess the robustness of our YLD estimates by comparing our estimated weighted mean disability weight with those of the GBD (Additional file 2: chapter 2). It is likely that the proportion of OAE cases experiencing different levels of epilepsy severity vary by mf intensity level and by treatment history. It is also possible that severity of OAE may vary by geographical location due to different O. volvulus species with differing pathogenic potential, such is the case for blindness due to onchocerciasis [45]. Variation is also expected by level of healthcare access, given that a lower disability weight is applied to medically-controlled epilepsy cases. The disability weights from the GBD as shown in Table 3 are not collected for different age groups, and it would be interesting to validate the different assigned severity weights among especially children and young adults with epilepsy in onchocerciasis-endemic areas, as they are the ones with highest OAE prevalence. Ultimately, with so little available published information on the clinical details of the disease, it is hard to know how close this estimate is to the truth. However, the burden of OAE can be substantial as compared to other clinical manifestations of onchocerciasis. If we assume that OAE occurs throughout all onchocerciasis-endemic countries previously under the APOC mandate, the total YLD attributable to OAE would be 128 000 YLDs (39 300 + 88 700 = 128 000 YLDs) in 2015. The GBD estimated 989 653 YLDs due to onchocerciasis (i.e. skin disease, visual impairment, blindness) in the year 2015 for SSA [11]. The actual onchocerciasis burden (in terms of YLDs) would be approximately 12% higher if we would also take account of OAE. Out of the 3.5 million prevalent epilepsy cases in SSA (GBD estimate for 2015 [11]), 11% would be associated with onchocerciasis. Using the weighted mean disability weight for epilepsy, the YLDs due to OAE in APOC-areas forms about 10% of the estimated YLDs in SSA due to epilepsy overall (GBD estimate 2015: 1.31 million YLDs [11]).

Estimating the socioeconomic burden of OAE

Similar to the distribution of onchocerciasis, OAE occurs almost exclusively in remote areas where people are already disenfranchised by their socioeconomic status. Subsistence farming is generally the primary source of income, and adequate healthcare is often inaccessible [46]. OAE compounds this burden through the accrual of additional direct, indirect and intangible health-related costs [47].

Direct health-related costs include all payable fees related to care-seeking and medical treatment including: payment for transportation to and from a medical facility; costs of diagnostic testing, medication and physician consultation; cost of follow-up consultation and/or hospitalisation; and costs related to home-based care such as the cost accrued from an increased need for personal hygiene products like soap. Beyond the cost of diagnosing and treating OAE, PWE are more likely to acquire other direct health-related costs related to their higher propensity for cooking accidents that may cause severe burns requiring treatment and other incidental injuries. These expenditures reduce the amount of basic financial resources available to the household [48, 49]. Unlike onchocerciasis which has one drug of choice for its control, epilepsy treatments are multiple and their indications are different [50]. Data on the cost of epilepsy management in Africa is currently scarce. Findings from Burundi, Zambia, and South Africa suggest an annual cost of medication alone ranging from US$ 10 to US$ 48 [51,52,53]. Table 6 shows the average costs of one unit medicine for a PWE (other costs related to the medical management of PWE are currently not available).

Table 6 Costs related to medication for treating one person with epilepsy in US$. Adapted from [55]

To estimate the cost of treatment for all OAE cases in APOC countries, we multiplied the predicted number of cases in 2015 by the weighted mean of annual treatment costs of AEDs. No added cost is attributed to account for ivermectin as it is freely distributed by the Mectizan® Donation Programme [54]. We estimate that the total cost for treating all OAE cases in onchocerciasis-endemic areas where OAE has previously been reported or suspected would have been approximately US$12.4 million (117 000 OAE cases × US$ 106.31) in 2015. If OAE would occur in the whole of APOC-areas, we estimate there would be an additional US$28.1 million required (264 000 OAE cases × US$106.31) to treat all additional cases. These figures make up only part of the total direct cost since they do not account for cost of transportation and consultation/hospitalisation. The dosages are currently set to levels that are used in clinical practice of African settings [55]. However, non-adherence of patients to AED may be quite high in some settings (59–63%), overestimating the costs of AEDs as compared to actual usage [9, 56].

Furthermore, these estimates do not reflect the indirect and intangible costs of OAE. Indirect costs are related to lost productivity that is often a consequence of delayed diagnosis and treatment of epilepsy cases due to the limited availability and access to specialists trained in epilepsy care in Africa [57]. Several African countries reported a treatment gap of between 68 and 82% [58,59,60]. Untreated epilepsy is often associated with lower employment and education levels, and lower socioeconomic status [61]. Children with epilepsy may be banned from school, and adults with epilepsy may be barred from marriage or employment even if seizures do not render their work unsafe [62, 63]. Intangible costs are derived from the emotional and social impact of illness. OAE affects both PWE and caregivers. Caregivers may experience inordinate levels of stress, sleepless nights or burnout related to their responsibility of caring for the patient or their worry about the affected child wandering away [49]. Limited access to AEDs for PWE results in uncontrolled seizures with a high frequency of intellectual disability and psychiatric problems, rendering them extremely vulnerable to abuse and neglect. There have been anecdotal reports that suggest that women with epilepsy in SSA are sexually exploited, abused and have to exchange sex for basic necessities more frequently than unaffected women. This sexual assault also increases their risk for HIV/AIDS and other sexually transmitted infections [62] and if they become pregnant, they may be left with the additional burden of caring for a child [49].

A major challenge in holistically estimating the socioeconomic burden due to OAE is the difficulty in measuring costs because there are many unknown factors (e.g. loss of economy due to time away from work, denial from work of PWE). Therefore, these estimates do not reflect the indirect and intangible costs of OAE. Although we recognise the limitations of providing only costs of medicines, it appears that investing in direct costs (principally treatment with AED) would likely produce benefits in indirect costs (increased productivity) and intangible costs (improved quality of life), all outweighing the initial investment [10, 51]. Such cost estimations assist in making sure necessary resources become available and that the infrastructure can be set in place to target interventions in high-risk onchocerciasis-endemic communities.

Towards more accurate burden estimates

We have described the major challenges and limitations in our quantification of the number of cases, disease burden estimates (YLDs), and socioeconomic burden. These challenges and limitations can be solved through the acquisition of new and different types of data as well the use of more sophisticated statistical procedures or mathematical models. More data is needed on the prevalence of O. volvulus and epilepsy at the community-level of various levels of onchocerciasis endemicity. While some data has already been collected and published [4], there are a number of challenges in utilising it for estimation. Due to the different diagnostic methods and case definitions that are employed in different studies, the measured prevalence cannot be assumed to be comparable due to the divergent sensitivities and specificities. For epilepsy, an adapted case definition applicable in remote areas, including onchocerciasis-endemic areas, to establish aetiology of epilepsy in absence of neuroimaging would help in making study results comparable in future research and comparisons should be made with older diagnostics and case definitions to help equate and interpret results from past research.

Secondly, age- and sex-stratified information is vital in order to capture age- and sex-specific trends in prevalence and disease burden estimates. Epilepsy in onchocerciasis-endemic areas may have a different age pattern in the onset of epilepsy as compared to onchocerciasis non-endemic areas, with a peak onset of epilepsy between ages 10 and 15 years [7, 8, 64]. Age- and sex-stratified data are essential to be able to reproduce disease trends in the prevalence of OAE that can subsequently inform treatment policy, research and drug development efforts targeted at these higher-risk groups. In addition, data on the sex- and age-distribution of OAE deaths is required in order to calculate DALYs. Note that the collection of such data, however, may be quite challenging without the ability to confirm that the epilepsy is caused by onchocerciasis.

Thirdly, there is limited data available about the premature mortality due to epilepsy. In a study in an onchocerciasis-endemic region in Cameroon the relative risk of death among PWE was 6.2 times (95% CI: 2.7–14.1) than among those without epilepsy [16]. Additional assessments of excess mortality due to OAE are necessary to refine our assumption of an excess mortality of 3.5% that we applied in the statistical model presented here, based on the study by Kamgno et al. [16]. This would have the effect of a different survival rate of OAE cases (age-stratified), and henceforth a better estimate of the incidence and prevalence of OAE cases across Africa.

Fourthly, very little data is available concerning the current incidence and prevalence of OAE in the majority of sub-Saharan African countries where onchocerciasis is endemic. The available data is concentrated in limited and very focal study sites. This both limits our ability to develop accurate disease burden estimates for vast areas as well as limits our understanding of the epidemiology of the OAE. We have now provided stratified estimates of OAE cases for areas where OAE has been reported or suspected and areas where we do not have any information from. Greater geographical coverage of OAE surveys is essential for making estimates more precise and ensuring that the full burden of OAE is captured.

Lastly, in addition to more refined and robust data, estimates of disease quantification can be refined through the use of modelling frameworks, both statistical and mathematical. Statistical models for the association between infection and morbidity may not well capture non-linearities in population dynamics, but they can make sophisticated estimates of current and future burden. In the past, a Bayesian, hierarchical meta-regression model was used to successfully estimate the burden attributable to epilepsy globally from 1980 to present [32]. Mathematical models may better capture transmission dynamics of onchocerciasis [65,66,67], such that OAE development is dependent on mf-production with a damage trigger after which epilepsy is allowed to develop. It is possible that damage susceptibility is age-dependent, which could be taken into account in a mathematical model. Likewise, the degree of excess mortality can be accounted for.

Policy implications

Since epileptic seizures can, under certain circumstances, be well controlled and an individual’s quality of life can be restored with treatment, there are significant gains that can be made for epilepsy patients. The majority of epilepsy patients in Africa do not receive appropriate care, due to limited financial means of households, high costs of AED, lack of proper diagnostics, and/or insufficient number of trained health workers or drug supplies [68]. Scaling-up of care (e.g. additional support and treatment with AED through decentralised services) is urgently needed [10]. The link between onchocerciasis and epilepsy may be exploited in two ways.

Firstly, the possible effect of onchocerciasis control efforts on the incidence of epilepsy may be reason to put in extra resources for the intensification of onchocerciasis elimination activities in highly endemic onchocerciasis areas where high prevalence rates of epilepsy are found [32]. Secondly, health systems can be strengthened in (often remote) highly endemic onchocerciasis areas with high epilepsy prevalence, to enhance timely referral of epilepsy patients (irrespective of the cause of the epilepsy). Community-directed distributors of ivermectin could be trained to identify potential epilepsy cases and refer them to the general health system, to ensure that they receive proper anti-epilepsy treatment. Such efforts may perhaps have little impact on the total epilepsy prevalence in SSA, but it would even so have adjuvant advantages for both onchocerciasis and epilepsy control and may even prevent the potentially significant impact of OAE. In some areas, this may require improvements in accessibility and affordability of healthcare services in order to increase utilisation. Most PWE will respond to AED in stock, at least with a reduction in seizure frequency, and therefore, if they are picked up in the community and referred, will benefit from the health services available.

Research priorities

We have demonstrated that there is a need to improve estimates of the burden of OAE by country, age and sex, including the calculation of YLLs, YLDs and DALYs attributable to OAE. We have identified six research priorities that need to be addressed in order to improve our understanding of OAE and make our estimates more precise (Table 7). These priorities should be included in the research and policy agendas of both onchocerciasis and epilepsy programmes in Africa. Sustained and intensified funding is required to prompt onchocerciasis elimination efforts in general, with special focus on high transmission zones (often associated with high potential of increased epilepsy prevalence). In addition, these research priorities may motivate health policy-makers to increase funding to health systems across SSA in general, with the aim of tackling epilepsy in these areas.

Table 7 Research priorities in the estimation of the current burden of OAE


Based on our estimates the number of persons with OAE in 2015 is estimated to be 117 000 (95% CI: 50 000–441 000) in onchocerciasis-endemic areas where OAE has been reported or suspected and 264 000 (95% CI: 109 000–1 195 000) in onchocerciasis-endemic areas where OAE has not yet been investigated. An educated analysis of the burden of OAE is imperative in order to delineate the type and scope of public health responses it requires, both in terms of efficient control interventions and availability of resources. Although the estimates presented here need further refinement, they provide a first step towards quantifying the burden of OAE that we can expect today. These numbers are useful for policy-makers and onchocerciasis and epilepsy programme managers who need to be aware of the public health impact caused by epilepsy in onchocerciasis-endemic areas. Intensification of onchocerciasis control efforts and/or increases in resources for epilepsy healthcare services would then be imperative for most affected areas. People living in onchocerciasis-endemic regions need to understand the full implication and potential gains of supporting and adhering to MDA programmes.


95% CI :

95% confidence interval


Anti-epileptic drugs


African Programme for Onchocerciasis Control


Disability-adjusted life years


Global burden of disease


International League Against Epilepsy


Lymphatic filariasis


Mass drug administration






Nodule prevalence


Neglected tropical diseases


Onchocerciasis-associated epilepsy

OR :

Odds ratio


People with epilepsy


People without epilepsy


Sub-Saharan Africa


Years of life lived with disability


Years of life lost


  1. WHO. Accelerating work to overcome the global impact of neglected tropical diseases – A roadmap for implementation. 2012. Accessed 2 May 2016.

  2. Boussinesq M, Pion SDS, -Ngangue D, Kamgno J. Relationship between onchocerciasis and epilepsy: a matched case-control study in the Mbam Valley, Republic of Cameroon. Trans R Soc Trop Med Hyg. 2002;96:537–41.

    Article  CAS  Google Scholar 

  3. Kaiser C, Pion SDS, Boussinesq M. Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis. PLoS Negl Trop Dis. 2013;7:e2147.

    Article  Google Scholar 

  4. Pion SDS, Kaiser C, Boutros-Toni F, Cournil A, Taylor MM, Meredith SEO, et al. Epilepsy in onchocerciasis endemic areas: systematic review and meta-analysis of population-based surveys. PLoS Negl Trop Dis. 2009;3:e461.

    Article  Google Scholar 

  5. Kaiser C, Kipp W, Asaba G, Mugisa C, Kabagambe G, Rating D, et al. The prevalence of epilepsy follows the distribution of onchocerciasis in a west Ugandan focus. Bull World Health Organ. 1996;74:361–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Kipp W, Kasoro S, Burnham G. Onchocerciasis and epilepsy in Uganda. Lancet. 1994;343:183–4.

    Article  CAS  Google Scholar 

  7. Levick B, Laudisoit A, Tepage F, Ensoy-Musoro C, Mandro M, Bonareri Osoro C, et al. High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo. PLoS Negl Trop Dis. 2017;11:e0005732.

    Article  Google Scholar 

  8. Colebunders R, Tepage F, Rood E, Mandro M, Abatih EN, Musinya G, et al. Prevalence of river epilepsy in the Orientale province in the Democratic Republic of the Congo. PLoS Negl Trop Dis. 2016;10:e0004478.

    Article  Google Scholar 

  9. Ba-Diop A, Marin B, Druet-Cabanac M, Ngoungou EB, Newton CR, Preux P-M. Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol. 2014;13:1029–44.

    Article  Google Scholar 

  10. Chin JH. Epilepsy treatment in sub-Saharan Africa: closing the gap. Afr Health Sci. 2012;12:186–92.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. GHDx. Global Health Data Exchange. GBD results tool. Accessed 12 Dec 2017.

  12. Paul A, Adeloye D, George-Carey R, Kolčić I, Grant L, Chan KY. An estimate of the prevalence of epilepsy in sub-Saharan Africa: a systematic analysis. J Glob Health. 2012;2:20405.

    Article  Google Scholar 

  13. Colebunders R, Njamnshi AK, van Oijen M, Mukendi D, Kashama JM, Mandro M, et al. Onchocerciasis-associated epilepsy: from recent epidemiological and clinical findings to policy implications. Epilepsia Open. 2017;2:145–52.

    Article  Google Scholar 

  14. Colebunders R, Hendy A, van Ooijen M. Nodding syndrome in onchocerciasis endemic areas. Trends Parasitol. 2016;32:581–3.

    Article  CAS  Google Scholar 

  15. Cicero WS. Epilepsy in the WHO African region: bridging the gap. The Global Campaign Against Epilepsy: Out of the Shadows. World Health Organization 2004. Accessed 28 Nov 2017.

  16. Kamgno J, Pion SDS, Boussinesq M. Demographic impact of epilepsy in Africa: results of a 10-year cohort study in a rural area of Cameroon. Epilepsia. 2003;44:956–63.

    Article  Google Scholar 

  17. Winkler AS. Neurocysticercosis in sub-Saharan Africa: a review of prevalence, clinical characteristics, diagnosis, and management. Pathog Glob Health. 2012;106:261–74.

    Article  Google Scholar 

  18. Ndimubanzi PC, Carabin H, Budke CM, Nguyen H, Qian Y-J, Rainwater E, et al. A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy. PLoS Negl Trop Dis. 2010;4:e870.

    Article  Google Scholar 

  19. Dozie INS, Onwuliri COE, Nwoke BEB, Chukwuocha UM, Chikwendu CI, Okoro I, et al. Onchocerciasis and epilepsy in parts of the Imo river basin, Nigeria: a preliminary report. Public Health. 2006;120:448–50.

    Article  CAS  Google Scholar 

  20. Druet-Cabanac M, Bertocchi I, Preux PM. Onchocerciasis and epilepsy in the north west region of Central African Republic. Afr J Neurol Sci. 1998;17:37–8.

    Google Scholar 

  21. Kamuyu G, Bottomley C, Mageto J, Lowe B, Wilkins PP, Noh JC, et al. Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa. PLoS Negl Trop Dis. 2014;8:e2908.

    Article  Google Scholar 

  22. Newell ED, Vyungimana F, Bradley JE. Epilepsy, retarded growth and onchocerciasis, in two areas of different endemicity of onchocerciasis in Burundi. Trans R Soc Trop Med Hyg. 1997;91:525–7.

    Article  CAS  Google Scholar 

  23. Montano SM, Villaran MV, Ylquimiche L, Figueroa JJ, Rodriguez S, Bautista CT, et al. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology. 2005;65:229–33.

    Article  CAS  Google Scholar 

  24. Del Brutto OH. Diagnostic criteria for neurocysticercosis, revisited. Pathog Glob Health. 2012;106:299–304.

    Article  Google Scholar 

  25. Chesnais CB, Zoung-Bissek A, Tatah G, Nana-Djeunga HCKJ, Colebunders R, Boussinesq M. First evidence by a cohort study in Cameroon that onchocerciasis does induce epilepsy. 1st Int. Work. onchocerciasis Assoc. epilepsy 12-14 Oct. 2017. Antwerp: Abstract 15; 2017.

    Google Scholar 

  26. Mbonye Bo MK, Gumisiriza N, Lawko T, Makumbi I, Idro R, Onen H, Colebunders R. Prevalence and annual incidence of nodding syndrome and other forms of epilepsy in onchocerciasis endemic areas in northernUganda. Abstr. 24, First International workshop on Onchocerciasis associated epilepsy 12-14 October 2017. Accessed 7 Sept 2018.

  27. Njamnshi AK, Zoung-Kanyi Bissek AC, Tabah EN, Ngarka L, Chokote E, Nfor LN, Mengnjo M, Siewe J,Dema F, Tatah GY, Boullé C, Suykerbuyk P, Kamgno J, Chesnais C, Boussinesq M, Colebunders R. Age shift of persons with epilepsy in Bilomo, Cameroon, following ivermectin mass drug administration for onchocerciasis. Abstr. 17, First International workshop on Onchocerciasis associated epilepsy 12-14 October 2017. Accessed 7 Sept 2018.

  28. Kipp W, Burnham G, Kamugisha J. Improvement in seizures after ivermectin. Lancet. 1992;340:789–90.

    Article  CAS  Google Scholar 

  29. Colebunders R, Mandro M, Mukendi D, Dolo H, Suykerbuyk P, Van Oijen M. Ivermectin treatment in patients with onchocerciasis-associated epilepsy: protocol of a randomized clinical trial. JMIR Res Protoc. 2017;6:e137.

    Article  Google Scholar 

  30. Johnson TP, Tyagi R, Lee PR, Lee M-H, Johnson KR, Kowalak J, et al. Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus. Sci Transl Med. 2017;9:6953.

    Article  Google Scholar 

  31. Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the international league against epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia. 2017;58:522–30.

    Article  Google Scholar 

  32. Colebunders R, Nelson Siewe FJ, Hotterbeekx A. Onchocerciasis-associated epilepsy, an additional reason for strengthening onchocerciasis elimination programs. Trends Parasitol. 2018;34:208–16.

    Article  Google Scholar 

  33. Winkler AS, Schaffert M, Schmutzhard E. Epilepsy in resource poor countries - suggestion of an adjusted classification. Epilepsia. 2007;48:1029–30.

    Article  Google Scholar 

  34. Kaiser C, Rubaale T, Tukesiga E, Kipp W, Kabagambe G, Ojony JO, et al. Association between onchocerciasis and epilepsy in the Itwara hyperendemic focus, West Uganda: controlling for time and intensity of exposure. Am J Trop Med Hyg. 2011;85:225–8.

    Article  Google Scholar 

  35. Ovuga E, Kipp W, Mungherera M, Kasoro S. Epilepsy and retarded growth in a hyperendemic focus of onchocerciasis in rural western Uganda. East Afr Med J. 1992;69:554–6.

    CAS  PubMed  Google Scholar 

  36. Taylor MM, Meredith SEO, Stufe A. The prevalence of epilepsy in an area hyperendemic for onchocerciasis in Tanzania. Am J Trop Med Hyg. 1999;61:416.

    Google Scholar 

  37. Mmbando BP, Suykerbuyk P, Mnacho M, Kakorozya A, Matuja W, Hendy A, Greter H, Makunde WH, Colebunders R. High prevalence of epilepsy in two rural onchocerciasis endemic villages in the Mahenge area, Tanzania, after 20 years of community directed treatment with ivermectin. Infect Dis Poverty. 2018;7(1):64.

  38. Gbenou H. Contribution à l’étude de l’association onchocercose-épilepsie. Résultats préliminaires d’une enquête neuroépidémiologique à Agbogbomé commune de Paouignan, sous-préfecture de Dassa-Zoumé, au Bénin [MD Thesis]. Cotonou: Cotonou Univ. Natl. du; 1995.

    Google Scholar 

  39. Colebunders R, Mandro M, Mokili JL, Mucinya G, Mambandu G, Pfarr K, et al. Risk factors for epilepsy in bas-Uélé Province, Democratic Republic of the Congo: a case-control study. Int J Infect Dis. 2016;49:1–8.

    Article  Google Scholar 

  40. Spencer PS, Vandemaele K, Richer M, Palmer VS, Chungong S, Anker M, et al. Nodding syndrome in Mundri county, South Sudan: environmental, nutritional and infectious factors. Afr Health Sci. 2013;13:183–204.

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Zouré H, Noma M, Tekle AH, Amazigo UV, Diggle PJ, Giorgi E, et al. The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for onchocerciasis control: (2) pre-control endemicity levels and estimated number infected. Parasit Vectors. 2014;7:326.

    Article  Google Scholar 

  42. Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388:1545–602.

    Article  Google Scholar 

  43. Salomon JA, Vos T, Hogan DR, Gagnon M, Naghavi M, Mokdad A, et al. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the global burden of disease study 2010. Lancet. 2012;380:2129–43.

    Article  Google Scholar 

  44. Prischich F, De Rinaldis M, Bruno F, Egeo G, Santori C, Zappaterreno A, et al. High prevalence of epilepsy in a village in the Littoral Province of Cameroon. Epilepsy Res. 2008;82:200–10.

    Article  Google Scholar 

  45. Dadzie KY, Remme J, Baker RH, Rolland A, Thylefors B. Ocular onchocerciasis and intensity of infection in the community. III. West African rainforest foci of the vector Simulium sanctipauli. Trop Med Parasitol. 1990;41:376–82.

    CAS  PubMed  Google Scholar 

  46. Colebunders R, Hendy A, Mokili JL, Wamala JF, Kaducu J, Kur L, et al. Nodding syndrome and epilepsy in onchocerciasis endemic regions: comparing preliminary observations from South Sudan and the Democratic Republic of the Congo with data from Uganda. BMC Res Notes. 2016;9:182.

    Article  Google Scholar 

  47. Thomas SV, Sarma PS, Alexander M, Pandit L, Shekhar L, Trivedi C, et al. Economic burden of epilepsy in India. Epilepsia. 2001;42:1052–60.

    Article  CAS  Google Scholar 

  48. Buchmann K. “These nodding people”: experiences of having a child with nodding syndrome in postconflict northern Uganda. Epilepsy Behav. 2015;42:71–7.

    Article  Google Scholar 

  49. Nakigudde J, Mutamba BB, Bazeyo W, Musisi S, James O. An exploration of caregiver burden for children with nodding syndrome (lucluc) in northern Uganda. BMC Psychiatry. 2016;16:255.

    Article  Google Scholar 

  50. NICE. Epilepsies: diagnosis and management. National Institute for health and care excellence; 2012. Available from: Accessed 3 Dec 2017.

    Google Scholar 

  51. Nsengiyumva G, Druet-Cabanac M, Nzisabira L, Preux P-M, Vergnenègre A. Economic evaluation of epilepsy in Kiremba (Burundi): a case-control study. Epilepsia. 2004;45:673–7.

    Article  Google Scholar 

  52. Wagner RG, Bertram MY, Gómez-Olivé FX, Tollman SM, Lindholm L, Newton CR, et al. Health care utilization and outpatient, out-of-pocket costs for active convulsive epilepsy in rural northeastern South Africa: a cross-sectional survey. BMC Health Serv Res. 2016;16:208.

    Article  Google Scholar 

  53. Birbeck GL, Chomba E, Mbewe E, Atadzhanov M, Haworth A, Kansembe H. The cost of implementing a nationwide program to decrease the epilepsy treatment gap in a high gap country. Neurol Int. 2012;4:e14.

    Article  Google Scholar 

  54. Thylefors B. The Mectizan donation program (MDP). Ann Trop Med Parasitol. 2008;102:39–44.

    Article  Google Scholar 

  55. Frye JE. Management Sciences for Health. Edition 2016. International medical products Price guide. 2015;

    Google Scholar 

  56. Ibinda F, Odermatt P, Kariuki SM, Kakooza-Mwesige A, Wagner RG, Owusu-Agyei S, et al. Magnitude and factors associated with nonadherence to antiepileptic drug treatment in Africa: a cross-sectional multisite study. Epilepsia Open. 2017;2:226–35.

    Article  Google Scholar 

  57. Wilmshurst JM, Kakooza-Mwesige A, Newton CR. The challenges of managing children with epilepsy in Africa. Semin Pediatr Neurol. 2014;21:36–41.

    Article  Google Scholar 

  58. Nwani PO, Nwosu MC, Enwereji KO, Asomugha AL, Arinzechi EO, Ogunniyi AO. Epilepsy treatment gap: prevalence and associated factors in Southeast Nigeria. Acta Neurol Scand. 2013;128:83–90.

    Article  CAS  Google Scholar 

  59. Hunter ER. The epidemiology of epilepsy in rural Tanzania: prevalence, phenotype, risk factors and treatment gap. Institute of Health and Society, Newcastle University. 2013;

    Google Scholar 

  60. Bugembe T. G309 epilepsy in Cameroon: a review of published literature for the development of a healthcare worker training tool. Achives Dis Childhood. 2014;99:126–7.

    Article  Google Scholar 

  61. Meyer A-C, Dua T, Ma J, Saxena S, Birbeck G. Global disparities in the epilepsy treatment gap: a systematic review. Bull World Health Organ. 2010;88:260–6.

    Article  Google Scholar 

  62. Baskind R, Birbeck GL. Epilepsy-associated stigma in sub-Saharan Africa: the social landscape of a disease. Epilepsy Behav. 2005;7:68–73.

    Article  Google Scholar 

  63. de Boer HM, Mula M, Sander JW. The global burden and stigma of epilepsy. Epilepsy Behav. 2008;12:540–6.

    Article  Google Scholar 

  64. Ngugi AK, Bottomley C, Kleinschmidt I, Wagner RG, Kakooza-Mwesige A, Ae-Ngibise K, et al. Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies. Lancet Neurol. 2013;12:253–63.

    Article  Google Scholar 

  65. Coffeng LE, Stolk WA, Zouré HGM, Veerman JL, Agblewonu KB, Murdoch ME, et al. African Programme for onchocerciasis control 1995-2015: model-estimated health impact and cost. PLoS Negl Trop Dis. 2013;e2032:7.

    Google Scholar 

  66. Stolk WA, Walker M, Coffeng LE, Basáñez M-G, de Vlas SJ. Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: a comparative modelling analysis. Parasit Vectors. 2015;8:552.

    Article  Google Scholar 

  67. Turner HC, Walker M, Churcher TS, Basáñez M-G. Modelling the impact of ivermectin on river blindness and its burden of morbidity and mortality in African Savannah: EpiOncho projections. Parasit Vectors. 2014;7:241.

    Article  Google Scholar 

  68. Mbuba CK, Ngugi AK, Newton CR, Carter JA. The epilepsy treatment gap in developing countries: a systematic review of the magnitude, causes, and intervention strategies. Epilepsia. 2008;49:1491–503.

    Article  Google Scholar 

  69. Coffeng LE, Pion SDS, O’Hanlon S, Cousens S, Abiose AO, Fischer PU, et al. Onchocerciasis: the pre-control association between prevalence of palpable nodules and skin microfilariae. PLoS Negl Trop Dis. 2013;7:e2168.

    Article  Google Scholar 

  70. United Nations, Department of Economic and Social Affairs PD. Population growth rates. World Population Prospects: The 2017 Revision, DVD Edition. 2017. Accessed 13 Mar 2018.

  71. Colebunders R, Titulaer M. Nodding syndrome: preventable and treatable. Sci Transl Med. 2017;9:377.

    Article  Google Scholar 

  72. Fullman N, Barber RM, Alemu Abajobir A, Hassen Abate K, Abbafati C, Abbas KM, et al. Measuring progress and projecting attainment on the basis of past trends of the health-related sustainable development goals in 188 countries: an analysis from the global burden of disease study 2016. Lancet. 2017;390:1423–59.

    Article  Google Scholar 

Download references


We would warmly like to thank Logora Makoy of the Ministry of Health, Sudan for his input during the burden estimate workshop in Antwerp. His thoughts assisted in the outline of this paper. Furthermore, we would like to thank Deby Mukendi and Eric de Smet for their brainstorm on case definitions. We also would like to acknowledge the contribution of Belén Pedrique on the research priorities section. Finally, we warmly acknowledge Jan Remme for the application of our logistic regression model on the pre-control onchocerciasis prevalence data at pixel-level.


WAS acknowledges the financial support from the Test-and-Treat (TNT) grant (Bill and Melina Gates Foundation (BMGF)). WAS, LEC and SJdV acknowledges the financial support from the Neglected Tropical Diseases (NTD) Modelling Consortium (Bill and Melina Gates Foundation (BMGF)). In addition, LEC work is co-funded by the Netherlands Organisation for Scientific Research (NWO). RC work is funded by the European Research Council (ERC) (AdG671055) and the Proof of Concept grant from the European Research Council (ERCpoc) (G768815). All other authors did not receive additional funding.

Author information

Authors and Affiliations



NVSVM, WAS, and RC initiated the idea for a research priority paper on burden estimates for OAE. NVSVM and SM chaired a workshop on burden estimates for OAE in Antwerp, from which the outline and content of the manuscript arose. All authors have contributed in the writing in and editing of the manuscript. NVSVM and WAS were the major contributors in the final version of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Natalie V. S. Vinkeles Melchers.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional files

Additional file 1:

Multilingual abstracts in the six official working languages of the United Nations. (PDF 654 kb)

Additional file 2:

Supplementary methodology, including baseline and summary tables, calculations of OAE cases, and sensitivity analysis. (DOCX 188 kb)

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vinkeles Melchers, N.V.S., Mollenkopf, S., Colebunders, R. et al. Burden of onchocerciasis-associated epilepsy: first estimates and research priorities. Infect Dis Poverty 7, 101 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: