Skip to main content

Disability progression among leprosy patients released from treatment: a survival analysis



Leprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy patients treated in Cáceres-MT, Brazil in the period 2000 to 2017.


A retrospective cohort study and survival analysis were performed in the hyperendemic municipality of Cáceres in the state of Mato Grosso. The study population consisted of newly diagnosed leprosy patients released from treatment between January 1, 2000 and December 31, 2017. The main outcome was the progression of the PD grade with regard to probability and time; and the evaluated covariates included clinical, operational and demographic variables. The Cox proportional risk model was used to estimate the risk ratio (Hazard Ratios) of the covariates. Both an univariate and a multivariate analysis were implemented, with 95% confidence intervals.


The mean time for progression of the PD grade was 162 months for PB and 151 months for MB leprosy patients. The survival curve showed that 15 years after the release from treatment, the probability of PD grade progression was 35%, with no difference between PB and MB or age groups. Leprosy reactions and registered medical complaints of any kind during treatment were identified as risk factors with Hazard Ratios of 1.6 and 1.8 respectively.


People released from treatment as cured of leprosy are susceptible to worsening of the PD, especially those who have had complications during multi-drug therapy treatment. This indicates that leprosy patients should be periodically monitored, even after the successful completion of multidrug therapy.


Physical disability (PD) can occur before leprosy diagnosis, during treatment and post-release from treatment [1]. However, although patients may be exposed to risk factors that potentiate the risk of more severe PD [2, 3] they stop being routinely evaluated once the treatment of active leprosy has been completed [4]. Any worsening of the PD of leprosy patients post-release from treatment is worrying, and a lack of comprehensive and systematic follow-up health care can leave cured leprosy patients neglected and vulnerable [3]. Many patients are released from treatment with leprosy reactions and neural impairment [5, 6] but are then excluded from active review of their disease status and adequate management of their conditions [7]. In Brazil, newly diagnosed leprosy patients are systematically recorded and monitored during multidrug therapy (MDT) and are considered cured at the end of treatment according to the paucibacillary (PB) or multibacillary (MB) treatment protocol, depending on the initial diagnosis [7]. In the period following release from treatment, the prevention of PD is based on self-care and patients are instructed to self-refer to health services in case they detect signs and symptoms of neural impairment [7].

The relevance of PD among leprosy patients is widely acknowledged. It is also well known that it can occur post-release from treatment either due to late detection [2, 8], late onset of leprosy reactions [3, 5, 9] or in the absence of qualified and timely assistance [10]. The lack of adherence to recommended self-care for prevention of PD as another contributing factor during treatment [11] and post-discharge has also been documented [12]. Unfortunately, the period post-discharge appears to be of minor concern to health authorities as indicated by the limited space and attention it receives in the guidelines on the recommended activities to prevent PD [7, 13].

According to WHO statistics for 2017, the number of leprosy cases diagnosed with grade 2 PD declined globally. The exception were five countries including Brazil where the figure increased by 10% over the previous year [14]. The Global Leprosy Strategy 2016–2020 has set as one target the reduction of leprosy cases with grade 2 PD to less than 1 per million inhabitants [15]. Of note, the leprosy burden is calculated based on the Disability-Adjusted Life Year (DALY) indicator, that combines mortality and morbidity information to measure the impact of disease on population health [16]. As leprosy is associated with low mortality, PD represents the main burden of disease due to leprosy, but the indicator only covers information collected at diagnosis and during treatment whereas the period post-release from treatment is not included [2, 8].

Considering the thousands of leprosy patients treated and released from treatment annually, and the long-term consequences of PD, the aim of this study was to evaluate the likelihood and factors associated with the progression of the PD grade post-release from treatment among leprosy patients in Cáceres-MT, Brazil in the period 2000 to 2017.


Study population and data sources

All leprosy patients treated and cured at the referral center for leprosy patients and eight urban units of the Primary Health Care System in the city of Cáceres were included in a retrospective cohort study and survival analysis with months as the unit of time. Cáceres is located in the western region of the state of Mato Grosso, the most leprosy-endemic state in Brazil and bordering the states of Mato Grosso do Sul, Goiás and Pará. It also shares an international border with Bolivia. As it is the case throughout Brazil, leprosy care is decentralized to the primary care facilities, with support by leprosy reference centers.

Release from treatment is defined as the end of treatment with MDT [7]. It is recorded as exit by cure in the leprosy monitoring bulletin in the National Information System of Notifiable Diseases (SINAN) [17].

The study population consisted of newly diagnosed leprosy patients who were released from treatment between 1 January 2000 and 31 December 2017. The study included mainly patients living in urban areas, all diagnosed and treated in the municipality and with a record of the assessment of the PD grade at diagnosis and at release from treatment. Exclusion criteria for the study were cases of grade 2 physical disability (G2D) at release from treatment because they already had the highest disability grade, according to the criteria of the Ministry of Health - Brazil [7, 18]. Follow-up losses were due to addresses which could not be verified, death, relocation outside the study area, and refusal to participate in the study.


The progression of the PD grade in the post-release from treatment period was defined as main outcome of the study. The term “progression” represents any worsening or advance in the PD and consequently, non-progression represents the maintenance or reduction of the PD grade. The considered covariates were: gender (male and female); educational level (illiterate, elementary school, high school, higher education and missing); age group (6–15, 16–29, 30–59 and 60 and more years); leprosy classification (PB and MB); leprosy reactions during treatment (yes/no); leprosy-related medical complaints during treatment (yes/no).

The addresses registered in the medical records and complementary information by the Community Health Workers and other health workers supported the identification of the current location of the participants. Data were obtained from medical records and a simplified neurological evaluation, and registered in a spreadsheet.

The simplified neurological assessment was performed to determine the current (= time of the study) grade of PD pertaining to the eyes, hands and feet [7]. Thus, the time between release from treatment and the assessment varied between participants. The single assessment was performed in a health facility near the participants’ residence, by trained health workers supported by the researchers with experience in neurological assessment of leprosy patients. The PD grade was classified as follows: grade 0–G0D (no leprosy-related physical disability), grade 1–G1D (decreased strength and/or loss of sensation) and grade 2–G2D (presence of visible disabilities and deformities) [7, 13]. Individuals with open lesions requiring immediate care received assistance at home and, when necessary, were referred for care at the health unit closest to their residence.

The follow-up time was recorded in months and defined as the period between the date of release from MDT treatment and the post-discharge neurological assessment.

Statistical analysis

The Chi-square test was used to evaluate the proportion difference between covariates. To estimate Hazard Ratios (HR) of covariates, in both the univariate and multivariate analysis, the Cox proportional risk model was used, and 95% confidence intervals (95% CI) were calculated using the Wald test for each covariate. In the final model the adjusted variables were considered as well as the overall chi-square. Survival curves were constructed using the Kaplan-Meier method to assess the likelihood of leprosy PD progression in the post-release from treatment period. The log-rank test was used to evaluate the differences between the MB and PB groups regarding the delay until progression of the PD grade. Individuals who did not show progression of the PD grade and those not evaluated at follow-up (lost at follow-up) were censored at the end of the study. Statistical analysis was performed using the Statistical Package for the Social Sciences program (SPSS version 22.0; IBM Corp., Armonk, NY, USA).

The study was approved by the Ethics Committee of the Hospital Universitário Júlio Muller (authorization number 555567; 02/26/2014). All participants signed a Consent Form after they had received an oral and written explanation of the study during a visit to their home by a researcher and health workers.


Study cohort characteristics

Among the 618 potential participants initially considered eligible for inclusion in the study, 62.3% (n = 385) could be located and agreed to the assessment of the PD grade in the frame of the study. Unavailable potential participants were not located at the recorded address (20.4%), moved out of the municipality (10.5%), had died (6.5%) or refused to participate in the study (0.3%; Fig. 1).

Fig. 1

Flowchart of the follow-up of a cohort of leprosy patients released from treatment in Cáceres-MT, Brazil, in the period 2000 to 2017. Potentially eligible were individuals with an assessment of the physical disability grade at diagnosis and release from MDT treatment who were still living in Cáceres at the time of the study

No statistically significant differences with regard to gender, age group or operational leprosy classification were observed between the final study cohort and the patients lost to follow-up (Table 1).

Table 1 Comparison of key characteristics between the final study cohort of leprosy patients and potential study participants from Cáceres - MT, Brazil (index patients released from treatment in 2000 to 2017)

Risk of physical disability grade progression

The Cox proportional risk model indicated no significant difference in the risk of progression of the PD grade post-release from treatment between age groups and operational leprosy classifications. Leprosy reactions during the treatment period represented a 1.6 times greater risk of PD progression (HR: 1.6; 95% CI: 1.1–2.4). A record of leprosy-related complaints during treatment was associated with almost twice the risk of progression of the PD post-release from treatment (HR: 1.8; 95% CI: 1.3–2.4; Table 2).

Table 2 Hazard Ratio (HR) and 95% confidence intervals (CI) for the progression of the physical disability grade among leprosy patients in the post-release from treatment period, Cáceres - MT, Brazil (index patients released from treatment in 2000 to 2017)

The mean time for progression of the PD grade was 162 months for PB and 151 months for MB. The survival curve shows that after release from MDT treatment the risk of PD grade progression was similar for patients with PB and MB leprosy (P-value > 0.05; Fig. 2).

Fig. 2

Survival curve for PD grade progression post-release from MDT treatment for MB and PB leprosy patients released from treatment in 2000–2017; Cáceres – MT, Brazil

The mean time until progression of the PD grade was 130 months for patients with documented leprosy reactions during treatment. For individuals with recorded complaints during treatment the average time of progression of the PD grade was 139 months.


Our study shows that the cumulative probability of progression (worsening) of the PD grade of people treated and bacteriologically cured of leprosy increases with time. After 10 years this probability was 30%, and after 15 years it was 35% in a cohort of patients from Mato Grosso, Brazil. The risk of disability progression is associated with leprosy reactions and the presence of triggers for complaints during the MDT treatment phase. It is possible that some individuals rated with more severe PD at follow-up compared to the moment when they were released from treatment developed this condition before or during treatment, but it went unrecorded. However, particularly G2D (more severe) is characterized by visible deformities, generally precluding classification errors.

Peripheral neuropathies can be irreversible and cause emotional, social and economic problems to those affected [19]. Preventing disability is one of the priorities of the Global Leprosy Strategy. The emphasis of the WHO strategy is early detection to prevent cases with G2D at the time of diagnosis [15]. The relevance of early detection as an approach to reduce the risk of developing disabilities is undisputed [20]. Studies conducted in the post-release from treatment period showed that early diagnosis is associated with reduced risk of PD [2, 8, 21]. On the other hand, any delay in starting treatment increases the risk of PD developing in the post-release period [8]. Descriptive studies conducted in India and Nigeria [6, 22], in Brazil [3, 19, 23] and specifically in Mato Grosso [24] confirm our findings of considerable PD developing after treatment completion. For this reason, disability prevention measures including regular medical review of the former patients are recommended to continue after the completion of the MDT treatment. For this, primary care would need to be restructured to ensure the provision of standardized and quality services post-release from treatment [7, 25].

Our findings are also corroborated by observations on the cohort of MB leprosy patients treated at the Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro. A 40% probability of progression of PD 10 years after MDT completion has been documented for this group. The main difference between the two cohorts is that the present study followed up MB and PB patients in a hyperendemic area of Brazil who had been treated in primary care while the study by Sales et al. [2] focused on the follow-up of patients seen by referral service. This patient population tends to be more severely affected when compared to those treated by the primary care services. Indeed, Rio de Janeiro is considered low endemic for leprosy; however, the average patients have more severe complications when compared to their peers from Mato Grosso. From 2012 to 2016, the average new case detection rate (NCDR) in Rio de Janeiro was 7.2 cases per 100 000 inhabitants; in the same period, the rate of patients with G2D was 7.4 cases per 1 million inhabitants. In Mato Grosso, the NCDR was 88.9 per 100 000 inhabitants and the rate of patients with G2D was 446.6 cases per 1million inhabitants over the same period [26].

It is noteworthy that the multivariate analysis showed no significant difference between PB and MB cases with regard to the rate of PD progression. Of note, the classification of leprosy patients had to be taken at face value and could not be independently verified. Operationally, this means that all leprosy patients have a potential to develop PD post treatment completion and need to be considered in efforts to prevent leprosy sequelae. It is thus important to launch disability prevention activities for all patients, regardless of the clinical form and the treatment status.

Leprosy reactions are the main risk factor for the development of PD during [5, 22] and after treatment [6]. Our findings show that the occurrence of leprosy reaction episodes during MDT treatment increases by 96% the risk that the disability grade progresses to a more serious stage post-release from treatment. This corroborates findings by others [3, 8, 27]. In contrast, a study of treated MB leprosy patients revealed no association between leprosy reactions and the development of new disabilities, possibly suggesting that the worsening of the PD grade in the post-release period depends on the clinical management of cases during treatment [2].

Our findings show no association between age and the worsening of the PD grade in the post-release from treatment period, in accordance with other studies [2, 8]. Age may reflect late diagnosis and delayed treatment, which are the main causes of PD in adults [8] but apparently does not influence in itself the worsening of PD after treatment.

The development of PD can result in reduced physical capacity, the latter being essential for many professional activities [24]. It can thus render individuals more susceptible to unemployment and socially vulnerable [4, 28]. Being unemployed can interfere with people’s quality of life, compromise the self-support and financial maintenance of the family, causing social, psychological and economic problems [29]. Studies in India [30] and Brazil [3, 10] have described these relationships in detail.

Adherence to regular practice of self-care is low in former leprosy patients due to stigma, lack of knowledge about leprosy, inability to perform activities and lack of commitment to health [9]. The participation of cured patients in a self-care group contributes significantly to the acquisition of knowledge and improves self-care practices [31]. In Mato Grosso, there are currently no self-care groups in a majority of municipalities. After release from MDT treatment, people are no longer regularly seen by the health services and are advised to only return when identifying a neural disorder [7]. This recommendation may not be appropriate considering the socioeconomic profile of people who develop PD due to leprosy. Generally, the affected population has limited education and income [3, 19, 32], factors that may interfere with the understanding of the concept of self-care, with self-observation and with treatment seeking behavior [3].

Whereas reducing PD at the time of diagnosis is currently a priority for WHO and many countries [15], it is necessary to reorganize leprosy programs to offer care for all individuals affected by the disease, including those released from MDT treatment. The post-release care process should be standardized and the care structure available in the primary care network improved in view of the continuing demand for these services [3, 4, 23]. Of note, such services must complement self-care and -check by those affected by the disease but released from treatment to jointly contribute to the prevention of PD [11].

The Brazilian guidelines on leprosy patient care as well the training for leprosy prevention, diagnosis and treatment suggest a simplified neurological assessment. For this study, the PD grade assigned by the health services at the time of the assessment was used. The accuracy of these assessments is unknown. Also, changes in the PD not warranting a re-classification of the PD grade were not considered in the study.


The risk of worsening physical disabilities due to leprosy over a 15 year follow-up period is high. Indeed, more than one third of the individuals treated and registered as cured by health services in a hyperendemic area in Brazil showed clear signs of PD worsening. Especially people released from treatment as cured but who have had complications during treatment with MDT are at risk. Leprosy patients should be regularly examined for signs of disability even after the completion of MDT.

Availability of data and materials

From first author.



Grade 2 disability

HR :

Hazard ratio

CI :

Confidence interval






Multidrug therapy


New cases detection rate


Physical disability


World Health Organization


  1. 1.

    Withington SG, Joha S, Baird D, Brink M, Brink J. Assessing socio-economic factors in relation to stigmatization, impairment status, and selection for socio-economic rehabilitation: a 1-year cohort of new leprosy cases in North Bangladesh. Lepr Rev. 2003;74(2):120–32.

    CAS  PubMed  Google Scholar 

  2. 2.

    Sales AM, Campos DP, Hacker MA, Nery JAC, Düppre NC, Rangel E, et al. Progression of leprosy disability after discharge: is multidrug therapy enough? Tropical Med Int Health. 2013;18(9):1145–53.

    Article  Google Scholar 

  3. 3.

    Monteiro LD, Alencar CHM, Braga JCBKP, Castro MD, Heukelbach J. Physical disabilities in leprosy patients after discharge from multidrug therapy in northern Brazil. Cad Saúde Pública. 2013;29(5):909–20.

    Article  Google Scholar 

  4. 4.

    Barbosa JC, Ramos Junior AN, Alencar OM, Pinto MSP, Castro CGJ. Leprosy after release from treatment in the Brazilian unified health system: aspects for access in the northeast region. Cad Saúde Colet. 2014;22(4):351–8.

    Article  Google Scholar 

  5. 5.

    Costa LG, Cortela D, Soares RC, Ignotti E. Factors associated with the worsening of the disability grade during leprosy treatment in Brazil. Lepr Rev. 2015;86:265–72.

    PubMed  Google Scholar 

  6. 6.

    Pradeep NS, Mathew R. Grade 2 disability in leprosy: scenario in the post-elimination phase of leprosy from a tertiary care center. Indian J Lepr. 2017;89:127–37.

    Google Scholar 

  7. 7.

    Brazil. Secretariat of Health Surveillance. Guidelines for surveillance, care and elimination of leprosy as a public health problem: technical and operational manual. Brasília: Ministry of Health. 2016. Accessed 15 Aug 2019.

  8. 8.

    Kumar A, Girdhar A, Girdhar BK. Risk of developing disability in pre and post-multidrug therapy treatment among multibacillary leprosy: Agra MB cohort study. BMJ Open. 2012;2:1–7.

    Google Scholar 

  9. 9.

    Gascón LCH, Lorenzo GG, Día JFT, Arrieta MCP, Silva MD, Rumbault RC, et al. Lepra Tardía. Comportamiento clínico epidemiológico. La Habana. Período 2008-2016. Rev Leprol. 2017;31(3):167–75.

    Google Scholar 

  10. 10.

    Rodrigues NC, Castro LE, Silva JG, Fontana AP, Couto Neto B, Sá VW, et al. Physical disability and its social and functional repercussions in patients with leprosy after discharge from multidrug therapy. Lepr Rev. 2017;88:85–94.

    Google Scholar 

  11. 11.

    Galan NGA, Beluci ML, Marciano LHSC, Prado RBR, Oliveira NGG, Bonini AG, et al. Evaluation of household self-care practice in leprosy. Hansen Int. 2014;39(2):27–35.

    Google Scholar 

  12. 12.

    Batista TVG, Vieira CSCA, Paula MAB. Body image in educational actions in self-care for people who had leprosy. Physis Rev Sau Col. 2014;24(1):89–104.

    Google Scholar 

  13. 13.

    Brazil. Secretariat of Health Surveillance. Practical guide on leprosy. Brasília: Ministry of Health. 2017. Accessed 15 Aug 2019.

  14. 14.

    World Health Organization. Leprosy update 2018. Weekly Epidemiol Rec. 2018;35:445–56.

    Google Scholar 

  15. 15.

    World Health Organization. Global leprosy strategy 2016–2020: accelerating towards a leprosy-free world. New Delhi: World Health Organization; 2016.

    Google Scholar 

  16. 16.

    Murray CJ, Lopez AD. The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge: Harvard University Press; 1996.

    Google Scholar 

  17. 17.

    Brazil. Secretariat of Health Surveillance. Information System on Diseases of Compulsory Declaration – Sinan: rules and routines. Brasília: Ministry of Health. 2006.

  18. 18.

    Brazil. Secretariat of Health Surveillance. Guide to health surveillance 3th. ed. Brasília: Ministry of Health. 2019. Accessed 25 Aug 2019.

  19. 19.

    Vieira CSCA, Lobato ML, Figueira MCS, Amaral MCE, Vilel MFG, Silva EM. Life after leprosy treatment discharge: physical and social limitations. Indian J Lepr. 2018;90:177–88.

    Google Scholar 

  20. 20.

    Assis BPN, Lyon S, Grossi MAF, Rocha MOC. Risk factors for physical disability upon release from multidrug therapy in new cases of leprosy at a referral center in Brazil. Rev Inst Med Trop.

  21. 21.

    Richardus JH, Nicholls PG, Croft RP, Withington SG, Smith WCS. Incidence of acute nerve function impairment and reactions in leprosy: a prospective cohort analysis after 5 years of follow-up. Inter J Epid. 2004;33:337–43.

    Article  Google Scholar 

  22. 22.

    Chukwu JN, Ekeke N, Nwafor CC CC, Meka AO, Alphonsus C, et al. Worsening of the disability grade during leprosy treatment: prevalence and its determinants in southern Nigeria. Trans R Soc Trop Med Hyg. 2018;112:492–9.

    Article  Google Scholar 

  23. 23.

    Haefner K, Walther F, Chichava AO, Ariza L, Alencar CH, Alencar MJF, et al. High occurrence of disabilities caused by leprosy: census from a hyperendemic area in Brazil’s savannah region. Lepr Rev. 2017;88:520–32.

    Google Scholar 

  24. 24.

    Ramos JMH, Souto FJD. Disability after treatment among leprosy patients in Várzea Grande, state of Mato Grosso. Rev Soc Bras Med Trop. 2010;43(3):293–7.

    Article  Google Scholar 

  25. 25.

    Souza EA, Ferreira AF, Boigny RN, Alencar CH, Heukelbach J, Martins-Melo FR, et al. Leprosy and gender in Brazil: trends in an endemic area of the Northeast region, 2001–2014. Rev Saude Publica. 2018; doi:

    Article  Google Scholar 

  26. 26.

    Brazil. Secretariat of Health Surveillance. Boletim Epidemiológico. Hanseníase. 2018;49(04).

  27. 27.

    Raposo MT, Reis MC, Caminha AVDQ, Heukelbach J, Parker LA, Pastor-Valero M, et al. Grade 2 disabilities in leprosy patients from Brazil: need for follow-up after completion of multidrug therapy. PLoS Negl Trop Dis. 2018.

    Article  Google Scholar 

  28. 28.

    Monteiro LD, Alencar CHM, Barbosa CH, Novaes JC, Santana CCB, Silva CCBS, et al. Limited activity and social participation after hospital discharge from leprosy treatment in a hyperendemic area in North Brazil. Rev Bras Epidemiol. 2014;17(1):91–104.

    Article  Google Scholar 

  29. 29.

    Silveira MGB, Coelho AR, Rodrigues SM, Soares MM, Camillo GN. Hansen’s disease patients: psychological impact of the diagnosis. Psicol Soc. 2014;26(2):517–27.

    Article  Google Scholar 

  30. 30.

    Smith WCS, Nicholls PG, Das L, Barkataki P, Suneetha S, Suneetha L, Jadhav R, Rao PSS, Smith EPW, Diana N. J. Lockwood DNJ, Wim H. Van Brakel WH. Predicting neuropathy and reactions in leprosy at diagnosis and before incident events - results from the INFIR cohort study. PLoS Negl Trop Dis. 2009;

    Article  Google Scholar 

  31. 31.

    Brito KKG, Soares MJGO, Costa MML, Oliveira SHS. Practices and limitations of users with Hansen’s disease in care of skin lesions. Rev Enferm UFPE. 2014;8(1):16–7.

    Google Scholar 

  32. 32.

    Silva RSO, Serra SMFS, Gonçalves EGR, Silva AR. Leprosy in municipality of Buriticupu, state of Maranhão, Brazil: study of disabilities in individuals in post-discharge. Hansen Int. 2012;37(2):54–60.

    Google Scholar 

Download references


We thank the study participants for their time and collaboration. Letícia Gomes da Costa contributed to the proposal writing.


Research Foundation of the State of Mato Grosso and the Brazilian Ministry of Health (FAPEMAT/PPSUS 002/2013 - Proc 261606/2013).

Author information




E. Ignotti conceived the study; A. Rosendo dos Santos and P. Rodrigues de Souza Silva collected and analyzed the data; all co-authors contributed to interpreting the results and writing the manuscript. The author(s) read and approved the final manuscript.

Corresponding author

Correspondence to Peter Steinmann.

Ethics declarations

Ethics approval and consent to participate

Mentioned in manuscript.

Consent for publication

All co-authors consent to this submission.

Competing interests

The authors declare they have no competing interests.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

dos Santos, A.R., Silva, P.R., Steinmann, P. et al. Disability progression among leprosy patients released from treatment: a survival analysis. Infect Dis Poverty 9, 53 (2020).

Download citation


  • Leprosy
  • Physical disability
  • Cure
  • Progression
  • Survival