Articles

Effect of using electronic medication monitors on tuberculosis treatment outcomes in China: a longitudinal ecological study

In China, an indigenously developed electronic medication monitor (EMM) was designed and used in 138 counties from three provinces. Previous studies showed positive results on accuracy, effectiveness, acceptab...

Authors: Ni Wang, Lei Guo, Hemant Deepak Shewade, Pruthu Thekkur, Hui Zhang, Yan-Li Yuan, Xiao-Meng Wang, Xiao-Lin Wang, Miao-Miao Sun, Fei Huang and Yan-Lin Zhao

Human coronaviruses and therapeutic drug discovery

Coronaviruses (CoVs) are distributed worldwide and have various susceptible hosts; CoVs infecting humans are called human coronaviruses (HCoVs). Although HCoV-specific drugs are still lacking, many potent targ...

Authors: Lan-Gui Song, Qing-Xing Xie, Hui-Lin Lao and Zhi-Yue Lv

Process evaluation of E-learning in continuing medical education: evidence from the China-Gates Foundation Tuberculosis Control Program

E-learning is a growing phenomenon which provides a unique opportunity to address the challenges in continuing medical education (CME). The China-Gates Foundation Tuberculosis (TB) Control Program implemented ...

Authors: Zi-Yue Wang, Li-Jie Zhang, Yu-Hong Liu, Wei-Xi Jiang, Sheng-Lan Tang and Xiao-Yun Liu

Implementing a new tuberculosis surveillance system in Zhejiang, Jilin and Ningxia: improvements, challenges and implications for China’s National Health Information System

China is still faced with the public health challenge of tuberculosis (TB), and a robust surveillance system is critical for developing evidence-based TB control policies. The Tuberculosis Information Manageme...

Authors: Wei-Xi Jiang, Fei Huang, Sheng-Lan Tang, Ni Wang, Xin Du, Hui Zhang and Yan-Lin Zhao

Multi-source financing for tuberculosis treatment in China: key issues and challenges

The End Tuberculosis (TB) Strategy of the World Health Organization highlights the need for patient-centered care and social protection measures that alleviate the financial hardships faced by many TB patients...

Authors: Qian Long, Wei-Xi Jiang, Hui Zhang, Jun Cheng, Sheng-Lan Tang and Wei-Bing Wang

The application of social innovation in healthcare: a scoping review

Social innovation has been applied increasingly to achieve social goals, including improved healthcare delivery, despite a lack of conceptual clarity and consensus on its definition. Beyond its tangible artefa...

Authors: Lindi van Niekerk, Lenore Manderson and Dina Balabanova

Effects of management of infection source of echinococcosis in Linzhi, Tibet Autonomous Region of China

Echinococcosis is highly endemic in western and northern China. Tibet Autonomous Region (TAR) is the most serious prevalent area. Linzhi is located in southeastern part of TAR. Dogs are the primary infection s...

Authors: Ying Wang, Bing-Cheng Ma, Li-Ying Wang, Gongsang Quzhen and Hua-Sheng Pang

Trends in burden of multidrug-resistant tuberculosis in countries, regions, and worldwide from 1990 to 2017: results from the Global Burden of Disease study

Antituberculosis-drug resistance is an important public health issue, and its epidemiological patterns has dramatically changed in recent decades. This study aimed to estimate the trends of multidrug-resistant...

Authors: Ze-Jin Ou, Dan-Feng Yu, Yuan-Hao Liang, Wen-Qiao He, Yong-Zhi Li, Ya-Xian Meng, Hu-Sheng Xiong, Min-Yi Zhang, Huan He, Yu-Han Gao, Fei Wu and Qing Chen

Spatiotemporal visualization for the global COVID-19 surveillance by balloon chart

Considering the widespread of coronavirus disease 2019 (COVID-19) pandemic in the world, it is important to understand the spatiotemporal development of the pandemic. In this study, we aimed to visualize time-...

Authors: Ming-Fan Pang, Zuo-Ru Liang, Zhi-Da Cheng, Xin-Ping Yang, Jie-Wen Wu, Ke Lyu, Jing-Jing Xi, Zhong-Jie Li, Guo-Qing Shi, Yan-Ping Zhang, George F. Gao, Xiao-Peng Qi and Xiao-Ping Dong

Lymphatic filariasis, infection status in Culex quinquefasciatus and Anopheles species after six rounds of mass drug administration in Masasi District, Tanzania

Lymphatic filariasis (LF) elimination program in Tanzania started in 2000 in response to the Global program for the elimination of LF by 2020. Evidence shows a persistent LF transmission despite more than a de...

Authors: Eliza Lupenza, Dinah B. Gasarasi and Omary M. Minzi

Bridging the health inequality gap: an examination of South Africa’s social innovation in health landscape

Despite the end of apartheid in the early 1990s, South Africa remains racially and economically segregated. The country is beset by persistent social inequality, poverty, unemployment, a heavy burden of diseas...

Authors: Katusha de Villiers

Levels of vaccination coverage among HIV-exposed children in China: a retrospective study

Vaccination is crucial for human immunodeficiency virus (HIV)-exposed children because of their increased risk of morbidity and mortality from various vaccine-preventable diseases. However, studies have shown ...

Authors: Rui Shen, Ai-Ling Wang, Xiao-Ping Pan, Ya-Ping Qiao, Qian Wang, Xiao-Yan Wang, Shui-Ling Qu and Tong Zhang

Changes in newly notified cases and control of tuberculosis in China: time-series analysis of surveillance data

China has made progress in tuberculosis control, but this disease remains a burden in many regions of China. We performed time-series analysis to examine changes in the rates of newly notified and newly smear-...

Authors: Ye-Sheng Wang, Wen-Long Zhu, Tao Li, Wei Chen and Wei-Bing Wang

Detection of Schistosoma mansoni DNA using polymerase chain reaction from serum and dried blood spot card samples of an adult population in North-western Tanzania

Real-time polymerase chain reaction (PCR) is a sensitive and specific method for diagnosing schistosomiasis. However, this method should be performed in a laboratory, usually located distant from the sample co...

Authors: Antje Fuss, Humphrey D. Mazigo and Andreas Mueller

Polyparasitism with Schistosoma haematobium, Plasmodium and soil-transmitted helminths in school-aged children in Muyuka–Cameroon following implementation of control measures: a cross sectional study

Despite the ubiquity of polyparasitism, its health impacts have been inadequately studied. The aim of this study was to determine the prevalence and determinants of polyparasitism with Schistosoma haematobium, Pl...

Authors: Irene Ule Ngole Sumbele, Ofon Vitalis Otia, Orelien Sylvain Mtopi Bopda, Calvin Bisong Ebai, Helen KuoKuo Kimbi and Theresa Nkuo-Akenji

A new candidate vaccine for human brucellosis based on influenza viral vectors: a preliminary investigation for the development of an immunization schedule in a guinea pig model

A new candidate vector vaccine against human brucellosis based on recombinant influenza viral vectors (rIVV) subtypes H5N1 expressing Brucella outer membrane protein (Omp) 16, L7/L12, Omp19 or Cu–Zn SOD proteins ...

Authors: Dina Bugybayeva, Zhailaubay Kydyrbayev, Nadezhda Zinina, Nurika Assanzhanova, Bolat Yespembetov, Yerken Kozhamkulov, Kunsulu Zakarya, Sholpan Ryskeldinova and Kaissar Tabynov

Global burden of active smoking among people living with HIV on antiretroviral therapy: a systematic review and meta-analysis

Although the high burden of both active smoking and human immunodeficiency virus (HIV) is clearly known, the relationship between them is still not well characterized. Therefore, we estimated the global preval...

Authors: Boni Maxime Ale, Franck Amahowe, Motto Malea Nganda, Célestin Danwang, Nelly Njeri Wakaba, Ateeq Almuwallad, Franck Biaou Guy Ale, Alamou Sanoussi, Suleiman Hudu Abdullahi and Jean Joel Bigna

COVID-19 case fatality risk by age and gender in a high testing setting in Latin America: Chile, March–August 2020

Early severity estimates of coronavirus disease 2019 (COVID-19) are critically needed to assess the potential impact of the ongoing pandemic in different demographic groups. Here we estimate the real-time dela...

Authors: Eduardo A. Undurraga, Gerardo Chowell and Kenji Mizumoto

The new COVID-19 poor and the neglected tropical diseases resurgence

Authors: Peter J. Hotez, Alan Fenwick and David Molyneux

Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

Malaria and neglected communicable protozoa parasitic diseases, such as leishmaniasis, and trypanosomiasis, are among the otherwise called diseases for neglected communities, which are habitual in underprivile...

Authors: Justus Amuche Nweze, Florence N. Mbaoji, Yan-Ming Li, Li-Yan Yang, Shu-Shi Huang, Vincent N. Chigor, Emmanuel A. Eze, Li-Xia Pan, Ting Zhang and Deng-Feng Yang

Impact of multiple policy interventions on the screening and diagnosis of drug-resistant tuberculosis patients: a cascade analysis on six prefectures in China

The detection of drug-resistant tuberculosis (DR-TB) is a major health concern in China. We aim to summarize interventions related to the screening and detection of DR-TB in Jiangsu Province, analyse their imp...

Authors: Xiao-Yan Ding, Wen-Hui Mao, Wei Lu, Hao Yu, Qiao Liu, Peng Lu, Hui Jiang, Xing Zhang, Feng Lu, Jie Xu, Chong-Qiao Zhong, Jin-Liu Hu, Wei-Xi Jiang, Lei Guo, Sheng-Lan Tang and Li-Mei Zhu

Incidence and time-varying predictors of HIV and sexually transmitted infections among male sex workers in Mexico City

Male sex workers are at high-risk for acquisition of sexually transmitted infections (STIs), including human immunodeficiency virus (HIV). We quantified incidence rates of STIs and identified their time-varyin...

Authors: Karla Y. Ganley, Marta Wilson-Barthes, Andrew R. Zullo, Sandra G. Sosa-Rubí, Carlos J. Conde-Glez, Santa García-Cisneros, Mark N. Lurie, Brandon D. L. Marshall, Don Operario, Kenneth H. Mayer and Omar Galárraga

Predictors of malaria rapid diagnostic test positivity in a high burden area of Paletwa Township, Chin State in Western Myanmar

Despite major reductions in malaria burden across Myanmar, clusters of the disease continue to persist in specific subregions. This study aimed to assess the predictors of test positivity among people living i...

Authors: Pyae Linn Aung, Myat Thu Soe, Thit Lwin Oo, Aung Khin, Aung Thi, Yan Zhao, Yaming Cao, Liwang Cui, Myat Phone Kyaw and Daniel M. Parker

Accessing the syndemic of COVID-19 and malaria intervention in Africa

The pandemic of the coronavirus disease 2019 (COVID-19) has caused substantial disruptions to health services in the low and middle-income countries with a high burden of other diseases, such as malaria in sub...

Authors: Benyun Shi, Jinxin Zheng, Shang Xia, Shan Lin, Xinyi Wang, Yang Liu, Xiao-Nong Zhou and Jiming Liu

Experience and practice of the Emergency Operations Center, Chinese Center for Disease Control and Prevention: a case study of response to the H7N9 outbreak

Emergency Operations Center (EOC) is a place to provide response to public health emergencies. Chinese Center for Disease Control and Prevention (China CDC)’s EOC was officially established in 2016, which has ...

Authors: Fan Ding, Qun Li and Lian-Mei Jin

Risk factors associated with mortality of COVID-19 in 3125 counties of the United States

The number of cumulative confirmed cases of COVID-19 in the United States has risen sharply since March 2020. A county health ranking and roadmaps program has been established to identify factors associated wi...

Authors: Ting Tian, Jingwen Zhang, Liyuan Hu, Yukang Jiang, Congyuan Duan, Zhongfei Li, Xueqin Wang and Heping Zhang

Efforts to mitigate the economic impact of the COVID-19 pandemic: potential entry points for neglected tropical diseases

The damage inflicted by the coronavirus diseases 2019 (COVID-19) pandemic upon humanity is and will continue to be considerable. Unprecedented progress made in global health over the past 20 years has reverted...

Authors: John P. Ehrenberg, Jürg Utzinger, Gilberto Fontes, Eliana Maria Mauricio da Rocha, Nieves Ehrenberg, Xiao-Nong Zhou and Peter Steinmann

Neglected tropical diseases activities in Africa in the COVID-19 era: the need for a “hybrid” approach in COVID-endemic times

With the coronavirus disease 2019 (COVID-19) pandemic showing no signs of abating, resuming neglected tropical disease (NTD) activities, particularly mass drug administration (MDA), is vital. Failure to resume...

Authors: David Molyneux, Simon Bush, Ron Bannerman, Philip Downs, Joy Shu’aibu, Pelagie Boko-Collins, Ioasia Radvan, Leah Wohlgemuth and Chris Boyton

Epidemiology of Blastocystis infection from 1990 to 2019 in China

Blastocystis is ubiquitous presence in animals and humans worldwide and has a high level genetic diversity. The aim of this study was to conduct a summary of Blastocystis prevalence, subtypes (STs) in humans and ...

Authors: Chao-Qun Ning, Zhu-hua Hu, Jun-hu Chen, Lin Ai and Li-Guang Tian

Functional biomarker signatures of circulating T-cells and its association with distinct clinical status of leprosy patients and their respective household contacts

Leprosy is a chronic infectious disease classified into two subgroups for therapeutic purposes: paucibacillary (PB) and multibacillary (MB), closely related to the host immune responses. In this context it is ...

Authors: Pedro Henrique Ferreira Marçal, Rafael Silva Gama, Lorena Bruna Pereira de Oliveira, Olindo Assis Martins-Filho, Roberta Olmo Pinheiro, Euzenir Nunes Sarno, Milton Ozório Moraes and Lucia Alves de Oliveira Fraga

Evaluating the yield of systematic screening for tuberculosis among three priority groups in Ho Chi Minh City, Viet Nam

In order to end tuberculosis (TB), it is necessary to expand coverage of TB care services, including systematic screening initiatives. However, more evidence is needed for groups among whom systematic screenin...

Authors: Luan Nguyen Quang Vo, Andrew James Codlin, Rachel Jeanette Forse, Nga Thuy Nguyen, Thanh Nguyen Vu, Giang Truong Le, Vinh Van Truong, Giang Chau Do, Ha Minh Dang, Lan Huu Nguyen, Hoa Binh Nguyen, Nhung Viet Nguyen, Jens Levy, Knut Lonnroth, S. Bertel Squire and Maxine Caws

Visceral leishmaniasis in northwest China from 2004 to 2018: a spatio-temporal analysis

Although visceral leishmaniasis (VL), a disease caused by parasites, is controlled in most provinces in China, it is still a serious public health problem and remains fundamentally uncontrolled in some northwe...

Authors: Canjun Zheng, Liping Wang, Yi Li and Xiao-Nong Zhou

Comparison of patients hospitalized with COVID-19, H7N9 and H1N1

There is an urgent need to better understand the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), for that the coronavirus disease 2019 (COVID-19) continues to cause considerabl...

Authors: Li-Si Deng, Jing Yuan, Li Ding, Yuan-Li Chen, Chao-Hui Zhao, Gong-Qi Chen, Xing-Hua Li, Xiao-He Li, Wen-Tao Luo, Jian-Feng Lan, Guo-Yu Tan, Sheng-Hong Tang, Jin-Yu Xia and Xi Liu

Seventy years’ achievements of international cooperation by the National Institute of Parasitic Diseases at the Chinese Center for Disease Control and Prevention

With the promotion of national control programs on parasitic and tropical diseases in China, the National Institute of Parasitic Diseases (NIPD), Chinese Center for Disease Control and Prevention has gained si...

Authors: Ru-Bo Wang, Yi-Ting Hong and Xiao-Nong Zhou

Long-lasting microbial larvicides for controlling insecticide resistant and outdoor transmitting vectors: a cost-effective supplement for malaria interventions

The issues of pyrethroid resistance and outdoor malaria parasite transmission have prompted the WHO to call for the development and adoption of viable alternative vector control methods. Larval source manageme...

Authors: Guofa Zhou, Eugenia Lo, Andrew K. Githeko, Yaw A. Afrane and Guiyun Yan

Increased circulating level of interleukin-6 and CD8⁺ T cell exhaustion are associated with progression of COVID-19

Coronavirus disease 2019 (COVID-19) is pandemic. It is critical to identify COVID-19 patients who are most likely to develop a severe disease. This study was designed to determine the clinical and epidemiologi...

Authors: Peng-Hui Yang, Yi-Bo Ding, Zhe Xu, Rui Pu, Ping Li, Jin Yan, Ji-Luo Liu, Fan-Ping Meng, Lei Huang, Lei Shi, Tian-Jun Jiang, En-Qiang Qin, Min Zhao, Da-Wei Zhang, Peng Zhao, Ling-Xiang Yu…

Malaria epidemiology and stratification of incidence in the malaria elimination setting in Harari Region, Eastern Ethiopia

Ethiopia has shown notable progress in reducing the burden of malaria over the past two decades. Because of this progress, the country has shifted efforts from control to elimination of malaria. This study was...

Authors: Endashaw Esayas, Asefa Tufa, Fekadu Massebo, Abdulhamid Ahemed, Ibssa Ibrahim, Dereje Dillu, Eyuel Asemahegn Bogale, Solomon Yared and Kebede Deribe

Spatial inequality, characteristics of internal migration, and pulmonary tuberculosis in China, 2011–2017: a spatial analysis

Human migration facilitate the spread of tuberculosis (TB). Migrants face an increased risk of TB infection. In this study, we aim to explore the spatial inequity of sputum smear-positive pulmonary TB (SS + PT...

Authors: Wen-Chong He, Ke Ju, Ya-Min Gao, Pei Zhang, Yin-Xia Zhang, Ye Jiang and Wei-Bin Liao

From control to elimination: a spatial-temporal analysis of malaria along the China-Myanmar border

Malaria cases have declined significantly along the China-Myanmar border in the past 10 years and this region is going through a process from control to elimination. The aim of this study is to investigate the...

Authors: Fang Huang, Li Zhang, Jing-Bo Xue, Hong-Ning Zhou, Aung Thi, Jun Zhang, Shui-Sen Zhou, Zhi-Gui Xia and Xiao-Nong Zhou

Assessing preventive health behaviors from COVID-19: a cross sectional study with health belief model in Golestan Province, Northern of Iran

Coronavirus disease 2019 (COVID-19) is a new viral disease that has caused a pandemic in the world. Due to the lack of vaccines and definitive treatment, preventive behaviors are the only way to overcome the d...

Authors: Hossein Shahnazi, Maryam Ahmadi-Livani, Bagher Pahlavanzadeh, Abdolhalim Rajabi, Mohammad Shoaib Hamrah and Abdurrahman Charkazi

A comprehensive research agenda for zero leprosy

Leprosy control achieved dramatic success in the 1980s–1990s with the implementation of short course multidrug therapy, which reduced the global prevalence of leprosy to less than 1 in 10 000 population. Howev...

Authors: Peter Steinmann, Courtenay Dusenbury, David Addiss, Fareed Mirza and W. Cairns S. Smith

High prevalence of Babesia microti in small mammals in Beijing

Babesiosis is an emerging tick-borne zoonotic infectious disease. Babesia microti is responsible for most cases of human babesiosis globally. It is important to investigate the prevalence of B. microti in the mam...

Authors: Chun-Yan Wei, Xiao-Mei Wang, Zhen-Sheng Wang, Zhi-Hua Wang, Zeng-Zhi Guan, Lian-Hui Zhang, Xiang-Feng Dou and Heng Wang

Comparing the performance of time series models with or without meteorological factors in predicting incident pulmonary tuberculosis in eastern China

Many studies have compared the performance of time series models in predicting pulmonary tuberculosis (PTB), but few have considered the role of meteorological factors in their prediction models. This study ai...

Authors: Zhong-Qi Li, Hong-Qiu Pan, Qiao Liu, Huan Song and Jian-Ming Wang

A prolonged cholera outbreak caused by drinking contaminated stream water, Kyangwali refugee settlement, Hoima District, Western Uganda: 2018

On 23 February 2018, the Uganda Ministry of Health (MOH) declared a cholera outbreak affecting more than 60 persons in Kyangwali Refugee Settlement, Hoima District, bordering the Democratic Republic of Congo (...

Authors: Fred Monje, Alex Riolexus Ario, Angella Musewa, Kenneth Bainomugisha, Bernadette Basuta Mirembe, Dativa Maria Aliddeki, Daniel Eurien, Godfrey Nsereko, Carol Nanziri, Esther Kisaakye, Vivian Ntono, Benon Kwesiga, Daniel Kadobera, Lilian Bulage, Godfrey Bwire, Patrick Tusiime…

Spatiotemporal dynamics, risk areas and social determinants of dengue in Northeastern Brazil, 2014–2017: an ecological study

Dengue fever is an arthropod-borne viral disease caused by dengue virus (DENV) and transmitted by Aedes mosquitoes. The Northeast region of Brazil is characterized by having one of the highest dengue rates in the...

Authors: Rodrigo Feliciano do Carmo, José Valter Joaquim Silva Júnior, Andre Filipe Pastor and Carlos Dornels Freire de Souza

First detection of F1534C knockdown resistance mutation in Aedes aegypti (Diptera: Culicidae) from Cameroon

Aedes borne viral diseases, notably dengue, are increasingly reported in Cameroon with Aedes aegypti being a major vector. Data on insecticide resistance of this vector and underlying mechanisms needed for outbre...

Authors: Aurelie P. Yougang, Basile Kamgang, Theodel A. Wilson Bahun, Armel N. Tedjou, Daniel Nguiffo-Nguete, Flobert Njiokou and Charles S. Wondji

Moving from rhetoric to action: how Africa can use scientific evidence to halt the COVID-19 pandemic

The ongoing pandemic of the coronavirus disease 2019 has spread rapidly to all countries of the world. Africa is particularly predisposed to an escalation of the pandemic and its negative impact given its weak...

Authors: Olushayo Oluseun Olu, Joy Luba Lomole Waya, Sylvester Maleghemi, John Rumunu, David Ameh and Joseph Francis Wamala

Differences and similarities of high-resolution computed tomography features between pneumocystis pneumonia and cytomegalovirus pneumonia in AIDS patients

Accurately differentiating pneumocystis from cytomegalovirus pneumonia is crucial for correct therapy selection in AIDS patients. Hence, the goal of this study was to compare the computerized tomography (CT) f...

Authors: Chun-Jing Du, Jing-Yuan Liu, Hui Chen, Shuo Yan, Lin Pu, Hao-Feng Xiong, Pan Xiang, Chuan-Sheng Li, Ming Zhang, Ru-Ming Xie, Bu-Dong Chen and Ang Li

Perceived psychosocial health and its sociodemographic correlates in times of the COVID-19 pandemic: a community-based online study in China

Coronavirus disease 2019 (COVID-19) pandemic has been affecting people's psychosocial health and well-being through various complex pathways. The present study aims to investigate the perceived psychosocial he...

Authors: Gan-Yi Wang and Shang-Feng Tang

Spatial and spatio-temporal analysis of malaria cases in Zimbabwe

Although effective treatment for malaria is now available, approximately half of the global population remain at risk of the disease particularly in developing countries. To design effective malaria control st...

Authors: Isaiah Gwitira, Munashe Mukonoweshuro, Grace Mapako, Munyaradzi D. Shekede, Joconiah Chirenda and Joseph Mberikunashe